Projections of the Midlateral Posterior Hypothalamic Area Influencing Cardiorespiratory Function in Rats

Hinrichsen, Colin

doi:10.1159/000116538

Cited by 8 publications

(7 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…After injections of HRP, cells projecting to the habenula have been la beled in the area ventral to the fasciculus retroflexus, the supramamillary region, the interfascicular nu cleus, the paranigral area and the substantia nigra (compacta), comprising the mesohabenular dopa mine pathway [42], In other studies [18], the majority of cells contributing to this projection surround the fornix and extend laterally into the entopeduncular nucleus. This would be consistent with efferent pro jections of the perifornical area demonstrated by in jections of [3H]-leucine [12,21]. It should be noted, however, that in the dorsal approach to the MLPHA probes pass through the lateral edge of the lateral ha benular nucleus, and even our sham-operated rats showed some degeneration of the lateral habenula.…”

Section: Kainate Lesionssupporting

confidence: 89%

“…These projections were not shown by silver de generation following lesions in the MLPHA but have been shown by anterograde transport of labeled ami no acids from the MLPHA [21]. In the present study, extensive degeneration in the dentate gyrus of the dor sal hippocampus in all experiments appeared to result from damage to afferent fibers by the probe.…”

Section: Kainate Lesionssupporting

confidence: 42%

“…The fornix contained fibers la beled with leucine and HRP after injections into the MLPHA [21] and degenerating fibers following elec trolytic and acid lesions in this study. Grossman and Grossman [17] did not report degenerating fibers in the fornix or MTT following lateral hypothalamic area injections of KA.…”

Section: Kainate Lesionsmentioning

confidence: 48%

“…The presence of terminal de generation in the anterior cingulate frontal and piri form cortices in this study depended on the lesioning technique. The most common finding -a projection to the anterior cingulate cortex -is consistent with the demonstration of a projection from the MLPHA to the anterior cingulate cortex following labeled amino acid injections [21]. A problem with using KA, how ever, is that the mediodorsal nucleus, which projects to the cingulate cortex, is particularly sensitive to KA.…”

Section: Kainate Lesionsmentioning

confidence: 52%

“…Fifty-micrometer serial frozen sections were cut and processed according to method 2 of Fink and Heimer [I I); alternate sections were bleached, counterstained and examined un der both bright-and dark-field illumination. The efferent projec tions of the MLPHA revealed by this study were compared with those determined by iontophoretic injections of pHJ-leucine [21].…”

Section: Methodsmentioning

confidence: 99%

See 4 more Smart Citations

An Appraisal of Some Lesioning Methods Applied to the Posterior Hypothalamus in Rats

Hinrichsen¹,

Ryan²

1989

Brain Behav Evol

Self Cite

View full text Add to dashboard Cite

The behavioral changes and histological damage to the brain of rats were examined following lesions of the midlateral posterior hypothalamic area (MLPHA) made by passing electrical current through a metal electrode or through a glass pipette containing hydrogen ion (HCl) or kainic acid. Control experiments included placement of pipettes containing saline and imposing the same current as used in kainic-acid-containing electrodes (sham). Subcutaneous injections of kainic acid assessed damage that may be attributed to general neuronal cytotoxicity or limbic seizures. The effect of diazepam on alleviating behavioral changes and structural damage in kainic-acid-injected rats was examined. The current used to inject kainic acid produced significant damage to both neurons and axons of passage at the injection site. Degeneration of nerve terminals following kainic acid injections in the MLPHA was widespread, not predictably reduced by diazepam premedication and differed in only minor details from degeneration induced by subcutaneous injections.

show abstract

Section: Kainate Lesionssupporting

confidence: 89%

Section: Kainate Lesionssupporting

confidence: 42%

Section: Kainate Lesionsmentioning

confidence: 48%

Section: Kainate Lesionsmentioning

confidence: 52%

Section: Methodsmentioning

confidence: 99%

See 3 more Smart Citations

An Appraisal of Some Lesioning Methods Applied to the Posterior Hypothalamus in Rats

Hinrichsen¹,

Ryan²

1989

Brain Behav Evol

Self Cite

View full text Add to dashboard Cite

show abstract

Medullary projections to the vagus nerve and posterolateral hypothalamus

Hardy

1995

Anat. Rec.

View full text Add to dashboard Cite

show abstract

Functional and anatomical organization of cardiovascular pressor and depressor sites in the lateral hypothalamic area: I. descending projections

Allen

Cechetto

1992

J of Comparative Neurology

175

View full text Add to dashboard Cite

The present study describes the anatomical organization of projections from functionally defined cell groups of the lateral hypothalamic area. Cardiovascular pressor and depressor sites were identified following microinjection (5-50 nl) of 0.01-1.0 M L-glutamate or D,L-homocysteate into the anesthetized rat. Subsequent injections of Phaseolus vulgaris-leucoagglutinin (PHA-L) or wheat germ agglutinin-horseradish peroxidase (WGA-HRP) were made into pressor or depressor sites and their connections with the brainstem and spinal cord were traced. Decreases in blood pressure (10-45 mmHg) and heart rate (20-70 bpm) were elicited from tuberal (LHAt) and posterior (LHAp) regions of the lateral hypothalamic area (LHA). Depressor neurons in the LHAt have descending projections to the central gray, dorsal and median raphe nuclei, pedunculopontine tegmental nucleus, pontine reticular formation, medial and lateral parabrachial nuclei, laterodorsal tegmental region, and medullary reticular formation including the region of the lateral tegmental field, nucleus ambigous, and rostrocaudal ventral lateral medulla. In contrast, descending projections from depressor neurons in the LHAp have dense terminal fields in the rostral, middle, and commissural portions of the nucleus of the solitary tract and the lateral tegmental field as well as the ventrolateral central gray, pedunculopontine tegmental nucleus, and medial and lateral parabrachial nuclei. Both the LHAt and LHAp have light projections to the intermediate region of the cervical and thoracic spinal cord. Increases in blood pressure (10-40 mmHg) and heart rate (20-70 bpm) were elicited almost exclusively from neurons located medial to the LHAt and LHAp in a region surrounding the fornix, termed the perifornical area (PFA). Pressor cells in the PFA have descending projections to the central gray, dorsal and median raphe nuclei, laterodorsal tegmental nucleus, and Barrington's nucleus as well as a light projection to the commissural portion of the nucleus of the solitary tract and the intermediate region of the cervical and thoracic spinal cord. The retrograde labeling observed in the WGA-HRP studies indicates that cells in most terminal fields have reciprocal projections to the pressor and depressor regions of the LHA. The results demonstrate that groups of neurons in the lateral hypothalamus with specific cardiovascular function have differential projections to the brain stem.

show abstract

Projections of the Midlateral Posterior Hypothalamic Area Influencing Cardiorespiratory Function in Rats

Cited by 8 publications

References 38 publications

An Appraisal of Some Lesioning Methods Applied to the Posterior Hypothalamus in Rats

An Appraisal of Some Lesioning Methods Applied to the Posterior Hypothalamus in Rats

Medullary projections to the vagus nerve and posterolateral hypothalamus

Functional and anatomical organization of cardiovascular pressor and depressor sites in the lateral hypothalamic area: I. descending projections

Contact Info

Product

Resources

About