Modulatory effects of phytol on the antiemetic property of domperidone, possibly through the D2 receptor interaction pathway: in vivo and in silico studies

Rotundic acid (RA) is a naturally occurring pentacyclic triterpene with a multitude of pharmacological activities. The primary emphasis of this study is on summarizing the anticancer properties with the underlying mechanisms of RA and its derivatives, as well as the pharmacokinetic features. Data was collected (up to date as of November 10, 2023) from various reliable and authentic literatures by searching in different academic search engines, including PubMed, Springer Link, Scopus, Wiley Online, Web of Science, ScienceDirect, and Google Scholar. The findings imply that RA and its synthetic derivatives possess promising anti‐cancer properties against breast, colorectal, liver, and cervical cancers in various preclinical pharmacological test systems. The results also indicate that RA and its derivatives demonstrated anticancer effects via a number of cellular mechanisms, including apoptotic cell death, inhibition of oxidative stress, anti‐inflammatory effect, cytotoxicity, cell cycle arrest, anti‐proliferative effect, anti‐angiogenic effect, and inhibition of cancer cell migration and invasion. It has been proposed that RA and its derived compounds have the capability to serve as a hopeful chemotherapeutic agent, so further extensive clinical research is necessary.

Section: Biopharmaceutical Profile Of Rotundic Acidmentioning

confidence: 99%

Efficacy of Rotundic Acid and Its Derivatives as Promising Natural Anticancer Triterpenoids: A Literature‐Based Study

Bhuia,

Chowdhury,

Sonia

et al. 2024

“…These challenges can impede the delivery of an appropriate dose to the target site, resulting in reduced efficacy and potential treatment failure. [78,79] Therefore, addressing these issues is crucial to improving the chances of successful clinical outcomes.…”

Section: Physicochemical Properties and Biopharmaceutical Profile Of ...mentioning

confidence: 99%

“…Low solubility and poor absorption are prevalent issues that can significantly limit the bioavailability of therapeutic compounds during the clinical development stage. These challenges can impede the delivery of an appropriate dose to the target site, resulting in reduced efficacy and potential treatment failure [78,79] . Therefore, addressing these issues is crucial to improving the chances of successful clinical outcomes.…”

Section: Physicochemical Properties and Biopharmaceutical Profile Of ...mentioning

confidence: 99%

Anticancer Potential of the Plant‐Derived Saponin Gracillin: A Comprehensive Review of Mechanistic Approaches

Bhuia,

Chowdhury,

Sonia

et al. 2023

With the increasing prevalence of cancer and the toxic side effects of synthetic drugs, natural products are being developed as promising therapeutic approaches. Gracillin is a naturally occurring triterpenoid steroidal saponin with several therapeutic activities. It is obtained as a major compound from different Dioscorea species. This review was designated to summarize the research progress on the anti‐cancer activities of gracillin focusing on the underlying cellular and molecular mechanisms, as well as its pharmacokinetic features. The data were collected (up to date as of May 1, 2023) from various reliable and authentic literatures comprising PubMed, Springer Link, Scopus, Wiley Online, Web of Science, ScienceDirect, and Google Scholar. The findings demonstrated that gracillin displays promising anticancer effects through various molecular mechanisms, including anti‐inflammatory effects, apoptotic cell death, induction of oxidative stress, cytotoxicity, induction of genotoxicity, cell cycle arrest, anti‐proliferative effect, autophagy, inhibition of glycolysis, and blocking of cancer cell migration. Additionally, this review highlighted the pharmacokinetic features of gracillin, indicating its lower oral bioavailability. As a conclusion, it can be proposed that gracillin could serve as a hopeful chemotherapeutic agent. However, further extensive clinical research is recommended to establish its safety, efficacy, and therapeutic potential in cancer treatment.

“…To date, approximately 50 % of authorized drugs having high biocompatibility and low side effects have been derived from natural products. [1,2] Many people of Asia and Africa do not have sufficient capacity to take modern medical services and, therefore, still rely on traditional treatments. [3] Plants and its derived products are the primary source of therapeutics in the enormous majority of world's traditional medical systems due to their extensive range of therapeutic properties.…”

Section: Introductionmentioning

confidence: 99%

“…Natural products are the promising source of modern therapeutic agents. To date, approximately 50 % of authorized drugs having high biocompatibility and low side effects have been derived from natural products [1,2] . Many people of Asia and Africa do not have sufficient capacity to take modern medical services and, therefore, still rely on traditional treatments [3] .…”

Section: Introductionmentioning

confidence: 99%

Mikania micrantha Kunth: An Ethnopharmacological Treasure Trove of Therapeutic Potential

Ali Khan,

El‐Kersh,

Islam

et al. 2023

Self Cite

Mikania micrantha is utilized as a therapeutic for the treatment of various human ailments including insect bites, rashes and itches of skin, chicken pox, healing of sores and wounds, colds and fever, nausea, jaundice, rheumatism, and respiratory ailments. This study aimed at summarizing the traditional uses, phytochemical profile, and biological activities of M. micrantha based on obtainable information screened from different databases. The results suggest that fresh leaves and whole plant are frequently used in folk medicine. The plant contains more than 150 different phytochemicals under the following groups: essential oils, phenolics and flavonoids, terpenes, terpene lactones, glycosides, and sulfated flavonoids. It contains carbohydrates and micronutrients including vitamins and major and trace minerals. M. micrantha possesses antioxidant, anti‐inflammatory, anti‐microbial, anti‐dermatophytic, anti‐protozoal, anthelmintic, cytotoxic, anxiolytic, anti‐diabetic, lipid‐lowering and antidiabetic, spasmolytic, memory‐enhancing, wound‐healing, anti‐aging, and thrombolytic activities. No clinical studies have been reported to date. M. micrantha might be one of the potential sources of phytotherapeutic compounds against diverse ailments in humans. Studies are required to confirm its safety profile in experimental animals prior to initiating clinical trials. Moreover, adequate investigation is also crucial to clarify exact mechanism of action for each biological effect.