Modulatory effects of methanolic fruit fraction of<i>Pedalium murex</i>on sulphasalazine-induced male reproductive disruption

Sharma, Mahima; Arya, Dharmendra; Bhagour, Kiran; Gupta, Radhey S.

doi:10.1111/and.13190

Cited by 8 publications

(4 citation statements)

References 25 publications

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“…Hence, both extracts belong to category 5 of the globally harmonized system (GHS) of classifcation. Tis fnding agrees with prior data of Sharma et al [15] and Gomathi et al [24]. Our data revealed that the treatment with both extracts increased the food intake but did not modify the body weight gain.…”

Section: Discussionsupporting

confidence: 93%

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Acute and Repeated Dose 28-Day Oral Toxicity Study of the Aqueous Extracts from the Leafy Stem and Fruit of Pedalium murex D.Royen EX.L in Wistar Rats

Dossou-Agoin,

Sangaré-Oumar,

Sacramento

et al. 2023

Journal of Toxicology

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Background. Pedalium murex (P. murex) is used in folk medicine for treatment of male infertility. However, scientific data on its safety are limited. Objective. This study was carried out to assess the acute and repeated dose 28-day oral toxicity of the aqueous extracts from P. murex leafy stem and fruit in Wistar rats. Methods. The acute toxicity test was performed according to the line 423 of the Organization for Economic Cooperation and Development (OECD) guidelines. The rats were randomly divided into three groups (n = 3). The control group received distilled water, while the experimental groups were given at a single dose, 5000 mg/kg of each extract. The repeated dose 28-day oral toxicity was performed according to the line 407 of the OECD guidelines. 35 rats divided into 7 groups of 5 male rats each were daily treated for 28 days with each extract at 200 mg/kg, 400 mg/kg, and 800 mg/kg, respectively. The in-life parameters were recorded during the follow-up. At the end of this study, organ weights, hematology, biochemistry, and histology parameters were analyzed. Results. In the acute oral toxicity test, there was no morbidity or mortality related to the treatments. Both extracts belong therefore to category 5 of the globally harmonized system (GHS) of classification. In the repeated dose 28-day oral toxicity test, both extracts did not alter animal’s behavior. However, both extract administration led to proteinuria and renal damages. Conclusion. P. murex leafy stem and fruit aqueous extracts exhibited potential nephrotoxicity. Therefore, care should be taken when they are used over an extended period.

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Section: Discussionsupporting

confidence: 93%

“…Diferent experimental models have confrmed the effectiveness of P. murex leafy stem or fruit folkloric use as aphrodisiac or male fertility booster [14][15][16]. Our prior study has also revealed the protective activity of P. murex leafy stem aqueous extract at 400 mg/kg against lead-induced testicular toxicity in Wistar rats [14].…”

Section: Introductionmentioning

confidence: 83%

Acute and Repeated Dose 28-Day Oral Toxicity Study of the Aqueous Extracts from the Leafy Stem and Fruit of Pedalium murex D.Royen EX.L in Wistar Rats

Dossou-Agoin,

Sangaré-Oumar,

Sacramento

et al. 2023

Journal of Toxicology

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“…Pedalium murex methanol fruit fraction originated from Pedalium murex Linn. which is a famous folk medicine used for treating ulcers, digestive tonics, and puerperal diseases [ 70 ]. Sulphasalazine induced rats treated with this natural compound showed improved sperm motility, sperm density, spermatogenesis, and the number of germinal cells, interstitial cells, spermatid, preleptotene spermatocyte, fibroblast, and mature Leydig cells.…”

Section: Plant Extract and Infertilitymentioning

confidence: 99%

Role of Antioxidant Natural Products in Management of Infertility: A Review of Their Medicinal Potential

Noh

Kim

et al. 2020

Antioxidants

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Infertility, a couple’s inability to conceive after one year of unprotected regular intercourse, is an important issue in the world. The use of natural products in the treatment of infertility has been considered as a possible alternative to conventional therapies. The present study aimed to investigate the effects and the mechanisms of various natural products on infertility. We collected articles regarding infertility and natural products using the research databases PubMed and Google Scholar. Several natural products possess antioxidant properties and androgenic activities on productive factors and hormones. Antioxidants are the first defense barrier against free radicals produced by oxidative stress (OS). They remove reactive oxygen stress (ROS), reducing insulin resistance, total cholesterol, fat accumulation, and cancer growth. Moreover, various natural products increase endometrial receptivity and fertility ability showing androgenic activities on productive factors and hormones. For example, Angelica keiskei powder and Astragalus mongholicus extract showed anti-infertility efficacies in males and females, respectively. On the other hand, adverse effects and acute toxicity of natural products were also reported. Tripterygium glycoside decreased fertility ability both in males and females. Results indicate that management of infertility with natural products could be beneficial with further clinical trials to evaluate the safety and effect.

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“…Many other studies have elucidated that extracts of P. murex have aphrodisiac and curative effects in infertile male rats and could elevate penile erection index, sperm quality, sexual behaviour and fertility rate (Ankita, Prava, Kunal, & Sekhar, ; Balamurugan, Muralidharan, & Polapala, ; Patel et al, ; Sharma et al, ). Probably the application of diosgenin to relevant experimental biologic models will shed more light on its mechanism of action on the testis that leads to the improvement of androgen synthesis, spermatogenesis and testicular function.…”

Section: Pedalium Murexmentioning

confidence: 99%

Plants in the management of male infertility

Onuah

Singh

2020

Andrologia

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This review attempts to collate existing data and provide the perspectives for future studies on the effects of plants on the male gonads. For many of these medicinal plants such as Lepidium meyenii, Rupus coreanus, Tribulus terrestres, Panax ginseng, Petasites japonicas, Apium graveolens, Eurycoma longifólia, Pedalium murex, Corchorus depressus, Mucuna pruriens, Astragalus membranaceus, Nigella sativa, Crataegus monogyna, Fagara tessmannii, Phaleria macrocarpa, Anacyclus pyrethrum, Cynomorium songaricum and Morinda officinalis, the mechanism of actions of their active principles and crude extracts has been shown in both laboratory animals, in vitro, and human studies, and includes their antioxidant, anti‐inflammatory, spermatogenesis‐inducing, aphrodisiac, smooth muscle relaxing and androgenic properties. Several active chemical leads including glucosinolates, anthocyanins, protodioscin, ginsenosides, sesquiterpenes, phyto‐oestrogens, quassinoids, diosgenin, thymoquinone, proanthocyanidins and bajijiasu isolated from these plants are known to have target effects on the testis, but efforts have been limited in their application at the clinical level. There still appear to be many more extracts of medicinal plants that have not been characterised to determine the phytochemicals unique to them that have target effects on the gonads. Further, collaborative efforts at isolating pro‐drug candidates from medicinal plants for studies at the molecular, cellular and clinical level towards elucidating their mechanisms of action on the testes are therefore warranted in the light of the current male fertility crisis.

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Modulatory effects of methanolic fruit fraction ofPedalium murexon sulphasalazine-induced male reproductive disruption

Cited by 8 publications

References 25 publications

Acute and Repeated Dose 28-Day Oral Toxicity Study of the Aqueous Extracts from the Leafy Stem and Fruit of Pedalium murex D.Royen EX.L in Wistar Rats

Acute and Repeated Dose 28-Day Oral Toxicity Study of the Aqueous Extracts from the Leafy Stem and Fruit of Pedalium murex D.Royen EX.L in Wistar Rats

Role of Antioxidant Natural Products in Management of Infertility: A Review of Their Medicinal Potential

Plants in the management of male infertility

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