Modulatory effect of vitamin E against Diazinon induced oxidative stress in lymphoid organs in rats

Mohamed, Enas Ali Kamel

doi:10.7813/2075-4124.2014/6-2/a.19

Cited by 4 publications

(3 citation statements)

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“…The present results showed that the administration of DZN caused statistically decreases in levels of serum GSH and SOD while the level of serum MDA was significantly increased. These findings are consistent with previous investigations which indicated that DZN and other pesticides caused oxidative damage which was confirmed by a significant decrease in levels of serum SOD and GSH, and increase in the level of serum MDA (Suke et al, 2008, Padma et al, 2011, Salehi et al, 2012, Abbassy et al, 2014, Mohamed and Ali, 2014, Beydilli et al, 2015, Eraslan et al, 2015).…”

Section: Discussionsupporting

confidence: 93%

Protective effect of some plant oils on diazinon induced hepatorenal toxicity in male rats

Al-Attar

Elnaggar

Almalki

2017

Saudi Journal of Biological Sciences

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Environmental pollution and exposure to environmental pollutants are still some of the major global health issues. Pesticides have been linked to a wide range of health hazards. The toxicity of pesticides depends on several factors such as its chemical properties, doses, exposure period, exposure methods, gender, genetics, age, nutritional status and physiological case of exposed individuals. Medicinal plants, natural products and nutrition continue to play a central role in the healthcare system of large proportions of the world's population. Alternative medicine plays an important role in health services around the world. The aim of this study was to investigate the effect of olive, sesame and black seed oils on hepatorenal toxicity induced by diazinon (DZN) in male rats. The experimental animals were divided into nine groups. The first group served as control. The second group was exposed to DZN. The third group was treated with olive oil and DZN. Rats of the fourth group were subjected to sesame oil and DZN. Rats of the fifth group were exposed to black seed oil and DZN. The sixth, seventh and eighth groups were supplemented with olive, sesame and black seed oils respectively. Rats of the ninth group were treated with corn oil. Levels of serum alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, gamma glutamyl transferase, total bilirubin, creatinine, blood urea nitrogen and malondialdehyde were significantly increased in rats exposed to DZN. Moreover, levels of serum glutathione and superoxide dismutase were significantly decreased. Several histopathological changes were observed in the structures of liver and kidney due to DZN exposure. This study showed that these oils attenuated the physiological disturbances and histopathological alterations induced by DZN intoxication. Moreover, the antioxidant properties of these oils support the bioactive roles of its protective effects on DZN toxicity. This study therefore suggests that these oils could be used as preventive factors against the toxicity of DZN due to its antioxidant properties.

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Section: Discussionsupporting

confidence: 93%

Protective effect of some plant oils on diazinon induced hepatorenal toxicity in male rats

Al-Attar

Elnaggar

Almalki

2017

Saudi Journal of Biological Sciences

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“…In the present study, the administration of DZN induced oxidative stress which was confirmed by the increases of serum GSH and SOD levels and a decrease of MDA level. However, several experimental studies showed similar observations in rats and mice exposed to DZN and other pesticides (Salehi et al, 2012, Abbassy et al, 2014, Mohamed and Ali, 2014, Arafa et al, 2015, Beydilli et al, 2015, Eraslan et al, 2015, Liu et al, 2016). Recently, data indicate that the toxic action of pesticides may include the induction of oxidative stress and accumulation of free radicals in the cell.…”

Section: Discussionmentioning

confidence: 64%

Physiological study on the influence of some plant oils in rats exposed to a sublethal concentration of diazinon

Al-Attar

Elnaggar

Almalki

2018

Saudi Journal of Biological Sciences

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The present study was aimed to evaluate the influence of olive, sesame and black seed oils on levels of some physiological parameters in male rats exposed to diazinon (DZN). Body weight changes, and levels of serum total protein, albumin, glucose, triglycerides, cholesterol, high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), very low density lipoprotein cholesterol (VLDL-C), atherogenic index (AI), atherogenic coefficient (AC), cardiac risk ratio (CRR), glutathione (GSH), superoxide dismutase (SOD) and malondialdehyde (MAD) were selected as physiological parameters. The experimental animals were distributed into nine groups. Rats group exposed to DZN and fed with normal diet resulted in pronounced severe changes including reduced body weight gain rate, significantly increase in levels of serum albumin, glucose, cholesterol, LDL-C, AI, AC, CRR and MDA while levels of HDL-C, GSH and SOD were decreased. In rats treated with DZN, the supplementation of the olive, sesame and black seed oils showed remarkable lowering influences of physiological alterations. Moreover, the present results confirmed that these oils possess antioxidative effects against DZN toxicity. Finally, the present findings suggest that these oils are safe and promising agents for the treatment of physiological disturbances induced by DZN and may be also by other pollutants, and toxic and pathogenic factors.

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“…Especially, the treatment is carried out on animals with bone defects and diabetes, when using the low-level laser with 808nm and 904nm wavelengths to evaluate bone healing for diabetic animals; results showed that low-level laser accelerates bone healing. [19,20].…”

Section: Meanmentioning

confidence: 99%

Effective Bone Regeneration Treatment of Low-Level Laser

Trinh¹,

Tran²,

Thi³

et al.

Kalpa Publications in Engineering

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This experimental study aimed to evaluate if the effect simultaneously wavelengths of 780 nm and 940 nm enhances bone regeneration of the broken bone. Experiments on pets: 14 dogs, were randomly divided into 2 groups: group I (low-level laser therapy) and group II (control). The results showed that dogs in group I had better bone regeneration and bone marrow formation than the control group. Then, we treated 25 patients with different fracture levels. They agreed to enjoy our method. After treatment, the fracture is no longer visible on X-ray film. The majority of patients after treatment only feel no pain or mild pain. This suggests that osteoblasts are positively affected when projected by low-level laser. It is very practical for the treatment of older patients because osteoblasts grow slowly than osteoclast.

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Modulatory effect of vitamin E against Diazinon induced oxidative stress in lymphoid organs in rats

Cited by 4 publications

References 0 publications

Protective effect of some plant oils on diazinon induced hepatorenal toxicity in male rats

Protective effect of some plant oils on diazinon induced hepatorenal toxicity in male rats

Physiological study on the influence of some plant oils in rats exposed to a sublethal concentration of diazinon

Effective Bone Regeneration Treatment of Low-Level Laser

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