Modulator effect of a polysaccharide-rich extract from Caesalpinia ferrea stem barks in rat cutaneous wound healing: Role of TNF-α, IL-1β, NO, TGF-β

Medicinal plants with wound healing potential

“…It also reduced the tumor necrosis factor-α (TNF-α) expression, and the levels of prostaglandin E2, interleukin-1, malondialdehyde (MDA), total protein and myeloperoxidase (MPO). Moreover, it increased the expression of iNOS and TGF-β (Pereira et al, 2016).…”

“…Moreover, iNOS regulates keratinocytes proliferation (Frank et al, 1998). Polysaccharide-rich extract of C. ferrea has been to increase the expression of iNOS (Pereira et al, 2016).…”

“…Recently many plant extracts have been reported for wound healing activity and their cellular mechanism of wound healing has been studied extensively. It has been demonstrated that many plant extracts processed wound healing via angiogenesis (Mirmalek et al, 2015;Shen et al, 2017), activation of NF-κB (Nicolaus et al, 2017), favoring proinflammatory cytokines (Joshi et al, 2016), upregulation of iNOS (Pereira et al, 2016) and alpha-1 type-1 collagen (Krishnappa et al, 2016), fibroblast proliferation (Seyed et al, 2016;Öz et al, 2016), and anti-oxidant activity (Joshi et al, 2016). Thus, the aim of this review was to collect information about the cellular mechanisms of wound healing plants recently reported by the investigators and present them in an organized or systematic way.…”

Role of Schwann cells in cutaneous wound healing

“…Cutaneous repair occurs with an intricate cascade of interactions between cells present in the skin microenvironment, extracellular matrix proteins, and growth factors . A wide range of strategies have been developed for accelerating wound closure in skin lesions based on what we know so far about cutaneous healing . Deciphering the details of cellular and molecular mechanisms involved in dermal restoration is central in skin research.…”

“…8 A wide range of strategies have been developed for accelerating wound closure in skin lesions based on what we know so far about cutaneous healing. 9 Deciphering the details of cellular and molecular mechanisms involved in dermal restoration is central in skin research. Discovering key cells and the underlying mechanisms participating in wound healing will create novel therapeutic strategies for skin repair.…”