Modulation of vitellogenin synthesis through estrogen receptor beta-1 in goldfish () juveniles exposed to 17-β estradiol and nonylphenol

Soverchia, Laura; Ruggeri, Barbara; Palermo, Francesco Alessandro; Mosconi, Gilberto; Cardinaletti, Gloriana; Scortichini, Giampiero; Gatti, G.; Polzonetti-Magni, A.M.

doi:10.1016/j.taap.2005.04.013

Cited by 76 publications

(39 citation statements)

References 45 publications

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“…It is noteworthy to mention that we have documented high levels of ERba (and ERbb) in LMB ovarian tissue when plasma levels of E 2 were low, indicating that the transcriptional regulation of the ERbs may not be steroidal in nature and is cell-type specific (Sabo-Attwood et al 2004). In contrast, goldfish ERba mRNA was inducible by NP in the liver (Soverchia et al 2005) following chronic water exposure. The reason for this discrepancy is unclear but may be related to route and duration of exposure in the two experiments, or alternatively using primers that did not distinguish the different receptor isotypes.…”

Section: Regulation Of Lmb Er Isotype and Vtg1 Expression By Np In Vivomentioning

confidence: 70%

“…This level of induction (1 ng/ml) is similar to physiological levels seen in female LMB during active reproduction and corresponds to peak levels observed in this species during the annual reproductive cycle. Although NP has been shown to interact directly with the ERs of numerous species (White et al 1994, Kuiper et al 1998, Balaguer et al 1999, Nishikawa et al 1999, Gale et al 2004), a few reports have suggested that the estrogenic effects of NP in vivo are the result from altered levels of endogenous steroids (Acevedo et al 2005, Matsumura et al 2005, Soverchia et al 2005. Exposure of fathead minnows to NP also resulted in increased levels of plasma E 2 with a concomitant decrease in testosterone (Soverchia et al 2005).…”

Section: Regulation Of Lmb Er Isotype and Vtg1 Expression By Np In Vivomentioning

confidence: 99%

“…Previous reports demonstrate that NP binds directly to the estrogen receptor (ER) and subsequently induces transcription of downstream genes regulated by this pathway (Celius et al 1999). However, a few studies indicate that NP may also increase endogenous steroid receptor ligand levels (Thibaut & Porte 2004, Acevedo et al 2005, Soverchia et al 2005, begging the question of whether NP activates the receptors directly or indirectly by increasing estrogen levels in the blood. The fact that the estrogenic effects induced by NP are inhibited by ER antagonists, suggests that NP is working at least in part via ERs (Lee 1998, Wilson et al 2004.…”

Section: Introductionmentioning

confidence: 99%

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Distinct expression and activity profiles of largemouth bass (Micropterus salmoides) estrogen receptors in response to estradiol and nonylphenol

Sabo‐Attwood

Blum

Kroll

et al. 2007

Journal of Molecular Endocrinology

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The estrogen receptor (ER) signaling cascade is a vulnerable target of exposure to environmental xenoestrogens, like nonylphenol (NP), which are causally associated with impaired health status. However, the impact of xenoestrogens on the individual receptor isotypes (a, ba, and bb) is not well understood. The goal of these studies was to determine the impact of NP on largemouth bass (Micropterus salmoides) ER isotype expression and activity. Here, we show that hepatic expression levels of three receptors are not equivalent in male largemouth bass exposed to NP by injection. Transcript levels of the ERa subtype were predominantly induced in concert with vitellogenin similarly to fish exposed to 17b-estradiol (E 2 ) as measured by quantitative real-time PCR. NP also induced circulating plasma levels of estrogen, which may contribute to overall activation of the ERs. To measure the activation of each receptor isotype by E 2 and NP, we employed reporter assays using an estrogen response element (ERE)-luciferase construct. Results from these studies show that ERa had the greatest activity following exposure to E 2 and NP. This activity was inhibited by the antagonists ICI 182 780 and ZM 189 154. Furthermore, both bb and ba subtypes depressed ERa activation, suggesting that the cellular composition of receptor isotypes may contribute to the overall actions of estrogen and estrogenic contaminants via the receptors. Results from these studies collectively reveal the differential response of fish ER isotypes in response to xenoestrogens.

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Section: Regulation Of Lmb Er Isotype and Vtg1 Expression By Np In Vivomentioning

confidence: 70%

Section: Regulation Of Lmb Er Isotype and Vtg1 Expression By Np In Vivomentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Distinct expression and activity profiles of largemouth bass (Micropterus salmoides) estrogen receptors in response to estradiol and nonylphenol

Sabo‐Attwood

Blum

Kroll

et al. 2007

Journal of Molecular Endocrinology

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“…Regarding endocrine effects of chemicals in fish, most studies have focused on the levels of estrogen-response gene transcripts or the subsequently produced proteins, such as Vtg (Soverchia et al, 2005;Hayashi et al, 2007). The present study demonstrated that TBBPA could significantly up-regulate Vtg mRNA expression in adult males and juveniles.…”

Section: Expression Patterns Of Hormonal-response Genes In Mosquitofimentioning

confidence: 50%

“…The induction of hepatic Vtg mRNA and/or protein expression has been widely used as a specific biomarker for evaluating estrogenic potency of (xeno)estrogens in juvenile and male fish (Leusch et al, 2005;Soverchia et al, 2005). But the structural similarity of TBBPA to bisphenol A, a known weak environmental estrogen, suggests that this compound may have the ability to bind to the estrogen receptor and disrupt the signaling process of the endocrine system (Birnbaum and Staskal, 2004).…”

Section: Introductionmentioning

confidence: 99%

Hormonal effects of tetrabromobisphenol A using a combination of in vitro and in vivo assays

Huang

Ying

Liang

et al. 2013

Comparative Biochemistry and Physiology Part C: Toxicology &

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Altered levels of endocrine biomarkers in juvenile barramundi (Lates calcarifer; Bloch) following exposure to commercial herbicide and surfactant formulations

Kroon

Hook

Metcalfe

et al. 2015

Enviro Toxic and Chemistry

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Agricultural pesticides that are known endocrine disrupting chemicals have been detected in waters in the Great Barrier Reef catchment and lagoon. Altered transcription levels of liver vitellogenin (vtg) have been documented in wild populations of 2 Great Barrier Reef fisheries species and were strongly associated with pesticide-containing runoff from sugarcane plantations. The present study examined endocrine and physiological biomarkers in juvenile barramundi (Lates calcarifer) exposed to environmentally relevant concentrations of commercial herbicide (ATRADEX(®) WG Herbicide, DIUREX(®) WG Herbicide) and surfactant (ACTIVATOR(®) 90) formulations commonly used on sugarcane in the Great Barrier Reef catchment. Estrogenic biomarkers (namely, liver vtg messenger RNA and plasma 17β-estradiol) increased following exposure to commercial mixtures but not to the analytical grade chemical, suggesting an estrogenic response to the additives. In contrast, brain aromatase (cyp19a1b) transcription levels, plasma testosterone and 11-ketotestosterone concentrations, and gill ventilation rates were not affected by any of the experimental exposures. These findings support the assertion that exposure to pesticide-containing runoff from sugarcane plantations is a potential causative agent of altered liver vtg transcription levels in wild barramundi. Whether exposure patterns in the Great Barrier Reef catchment and lagoon are sufficient to impair fish sexual and reproductive development and ultimately influence fish population dynamics remains to be determined. These findings highlight the need to consider both active and so-called inert ingredients in commercial pesticide formulations for environmental risk assessments.

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Modulation of vitellogenin synthesis through estrogen receptor beta-1 in goldfish () juveniles exposed to 17-β estradiol and nonylphenol

Cited by 76 publications

References 45 publications

Distinct expression and activity profiles of largemouth bass (Micropterus salmoides) estrogen receptors in response to estradiol and nonylphenol

Distinct expression and activity profiles of largemouth bass (Micropterus salmoides) estrogen receptors in response to estradiol and nonylphenol

Hormonal effects of tetrabromobisphenol A using a combination of in vitro and in vivo assays

Altered levels of endocrine biomarkers in juvenile barramundi (Lates calcarifer; Bloch) following exposure to commercial herbicide and surfactant formulations

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