Modulation of transforming growth factor beta function in hepatocytes and hepatic stellate cells in rat liver injury

Date, Masataka; Matsuzaki, Koichi; Matsushita, Makoto; Tahashi, Yoshiya; Furukawa, Fukiko; Inoue, Katsumi

doi:10.1136/gut.46.5.719

Cited by 56 publications

(52 citation statements)

References 22 publications

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“…Czaja et al (3) reported that the TGF-β1 mRNA level started to rise significantly at 24 h, peaked at 48 h, and approached baseline levels by 72 h in the liver damaged by either carbon tetrachloride or galactosamine. Similar observations were made regarding the plasma level of TGF-β1 protein in the carbon tetrachloride-induced rat liver injury (5). Immunohistochemical examination revealed increased deposition of extracellular matrix components including collagen type 1 in areas with liver cell necrosis and along sinusoids of the galactosamine-injured rat liver (11).…”

Section: Figsupporting

confidence: 67%

The anti-fibrotic effect of green tea with a high catechin content in the galactosamine-injured rat liver

et al. 2007

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Previously, we reported that the oral administration of green tea rich in catechins restored levels of several biomarkers increasing in galactosamine-treated rats to nearly control values. These biomarkers included serum transaminase activities, serum concentrations of tumor necrosis factor-α and interleukin 1-β, and the hepatic mRNA expression of these inflammatory cytokines. In the present study, we examined possible anti-fibrotic effects of green tea in galactosamine-induced hepatitis. The results of the reverse transcription and polymerase chain reaction indicated that the increase in gene expression of the α1 chain of collagen type 1 and transforming growth factor β-1 in the injured liver 24 h post-injection of galactosamine was suppressed by the administration of green tea. Masson's trichrome staining demonstrated that the extent of fibrogenesis after 14 days was greater in the galactosamine-injured livers not treated with green tea than the treated ones. These results suggest that the drinking of green tea with a high catechin content may help to prevent and/or attenuate the development of fibrosis in hepatitis.

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Section: Figsupporting

confidence: 67%

The anti-fibrotic effect of green tea with a high catechin content in the galactosamine-injured rat liver

et al. 2007

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“…This frequently occurs in cancer cells, but it has been also observed in proliferating hepatocytes during liver regeneration (27,60). Several groups have described a downregulation of the TGF-␤ receptors during liver regeneration (25,35,50,61). This process occurs between 24 and 48 h after partial hepatectomy or CCl 4 injury, and it has been associated with the cell insensitivity to TGF-␤ during this period of time.…”

Section: Discussionmentioning

confidence: 99%

Up-regulated Transcriptional Repressors SnoN and Ski Bind Smad Proteins to Antagonize Transforming Growth Factor-β Signals during Liver Regeneration

Macı́as-Silva

Leu

et al. 2002

Journal of Biological Chemistry

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Transforming growth factor-␤ (TGF-␤) functions as an antiproliferative factor for hepatocytes. However, for unexplained reasons, hepatocytes become resistant to TGF-␤ signals and can proliferate despite the presence of TGF-␤ during liver regeneration. TGF-␤ is up-regulated during liver regeneration, although it is not known whether it is active or latent. TGF-␤ activity may be examined by assessing Smad activation, a downstream signaling pathway. Smad pathway activation during liver regeneration induced by partial hepatectomy or CCl 4 injury was examined by assessing the levels of phospho-Smad2 and Smad2-Smad4 complexes. We found that Smad proteins were slightly activated in quiescent liver, but that their activation was further en-

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“…In the liver, TGF-␤ inhibits proliferation of hepatocytes, while stimulating proliferation and activation of hepatic stellate cells (26). We have previously shown that YB-1 abrogates TGF-␤ signaling through its direct interaction with Smad3 followed by repression of collagen gene expression (9).…”

Section: Discussionmentioning

confidence: 99%

A Novel Small Compound That Promotes Nuclear Translocation of YB-1 Ameliorates Experimental Hepatic Fibrosis in Mice

Higashi

Tomigahara

Shiraki

et al. 2011

Journal of Biological Chemistry

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Modulation of transforming growth factor beta function in hepatocytes and hepatic stellate cells in rat liver injury

Cited by 56 publications

References 22 publications

The anti-fibrotic effect of green tea with a high catechin content in the galactosamine-injured rat liver

The anti-fibrotic effect of green tea with a high catechin content in the galactosamine-injured rat liver

Up-regulated Transcriptional Repressors SnoN and Ski Bind Smad Proteins to Antagonize Transforming Growth Factor-β Signals during Liver Regeneration

A Novel Small Compound That Promotes Nuclear Translocation of YB-1 Ameliorates Experimental Hepatic Fibrosis in Mice

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