Modulation of topical inflammation and visceral nociception by Vanillosmopsis arborea essential oil in mice

Leite, Gerlânia de Oliveira; Leite, Laura Hévila Inocêncio; Sampaio, Renata de Souza; Araruna, Mariana K.A.; Rodrigues, Fábio Fernandes Galvão; Menezes, Irwin Rose Alencar de; Costa, José Galberto Martins da; Campos, Adriana Rolim

doi:10.1016/j.bionut.2011.06.001

Cited by 12 publications

(8 citation statements)

References 31 publications

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“…edema was induced by applying 20 μl of arachidonic acid to the inner and outer surface of the right ear, while the left ear received 20 μl of acetone and was used as a control. Thirty minutes after application of arachidonic acid, mice (n = 30) were euthanized as described above, and a six-mm diameter plug was removed from both the treated and untreated ears with a punch and weighed [ 26 , 27 ].…”

Section: Methodsmentioning

confidence: 99%

LASSBio-1586, an N-acylhydrazone derivative, attenuates nociceptive behavior and the inflammatory response in mice

et al. 2018

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Pain and inflammation are complex clinical conditions that are present in a wide variety of disorders. Most drugs used to treat pain and inflammation have potential side effects, which makes it necessary to search for new sources of bioactive molecules. In this paper, we describe the ability of LASSBio-1586, an N-acylhydrazone derivative, to attenuate nociceptive behavior and the inflammatory response in mice. Antinociceptive activity was evaluated through acetic acid-induced writhing and formalin-induced nociception tests. In these experimental models, LASSBio-1586 significantly (p<0.05) reduced nociceptive behavior. Several methods of acute and chronic inflammation induced by different chemical (carrageenan, histamine, croton oil, arachidonic acid) and physical (cotton pellet) agents were used to evaluate the anti-inflammatory effect of LASSBio-1586. LASSBio-1586 exhibited potent anti-inflammatory activity in all tests (p<0.05). Study of the mechanism of action demonstrated the possible involvement of the nitrergic, serotonergic and histamine signaling pathways. In addition, a molecular docking study was performed, indicating that LASSBio-1586 is able to block the COX-2 enzyme, reducing arachidonic acid metabolism and consequently decreasing the production of prostaglandins, which are important inflammatory mediators. In summary, LASSBio-1586 exhibited relevant antinociceptive and anti-inflammatory potential and acted on several targets, making it a candidate for a new multi-target oral anti-inflammatory drug.

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Section: Methodsmentioning

confidence: 99%

LASSBio-1586, an N-acylhydrazone derivative, attenuates nociceptive behavior and the inflammatory response in mice

et al. 2018

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“…TPA is able to activate protein kinase C (PKC), which activates other enzymatic cascades in turn, such as mitogen-activated protein kinases (MAPK) and phospholipase A2 (PLA2), leading to the release of platelet activation factor (PAF) and arachidonic acid. This cascade of events stimulates vascular permeability, vasodilation, polymorphonuclear leukocytes migration, the release of histamine and serotonin and moderate synthesis of inflammatory eicosanoids by cyclooxygenase (COX) and 5-lipoxygenase (5-LOX) enzymes [34]. The antiinflammatory activity of the studied extract is probably attributed to COX and 5-LOX inhibitors, leukotriene B4 (LTB4) antagonists.…”

Section: Croton Oil-induced Ear Edema In Micementioning

confidence: 99%

Antioxidant and Anti-Inflammatory Activities of Rubus Fruticosus and Zizyphus Vulgaris Methanol Extracts

Meziti

Bouriche

Hichem

et al. 2017

Int J Pharm Pharm Sci

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Objective: This report is an attempt to study the phenolic composition of Rubus fruticosus (RFE) and Zizyphus vulgaris (ZVE) methanol extracts and evaluate their antioxidant and anti-inflammatory effects in-vitro and in-vivo. Methods:Total phenolic and total flavonoids contents of extracts were determined by spectrophotometric methods. Phenolic compounds were identified by HPLC-TOF/MS. The antioxidant activities were evaluated in vitro using DPPH, ABTS and FRAP assays. The effect of RFE and ZVE on DNA cleavage induced by H2O2 Results:The phytochemical analysis of these extracts showed that RFE possesses higher polyphenolic and flavonoid content than ZVE. in the same way RFE exerted the highest antioxidant capacity with IC UV-photolysis was also investigated. The antioxidant effect of RFE and ZVE was tested in vivo using the blood total antioxidant capacity test in mice. On the other hand, the anti-inflammatory activity was assessed in vivo using two models of acute inflammation ear edema and vascular permeability. 50 value of 14 µg/ml in DPPH assay, 1.58 mmol of Trolox E/mg extract and 3.39 of mmol FesO4/mg extract in ABTS, and FRAP assay respectively. The studied extracts showed a concentration-dependent protective effect on DNA cleavage induced by H2O2 UV-photolysis. The daily oral administration of 200 mg/kg of RFE or ZVE during three weeks showed an improvement of the blood total antioxidant capacity; the HT50 Conclusion:The results obtained in this investigation showed that RFE possesses strong antioxidant and anti-inflammatory potential in comparison with ZVE, which may be attributed to the presence of polyphenolic phytoconstituents. values were151.45 min and 146.72 min for the groups treated with RFE and ZVE, respectively versus 122.5 min for the control group. The topical application of 2 mg/ear of RFE inhibited the croton oil-induced ear edema by 75.72%, while the inhibition exerted by ZVE was 64.24%. These inhibitions were higher than that of indomethacin, used as a reference. Moreover, the oral administration of 400 mg/kg of RFE inhibited significantly (33.57%) acetic acid induced vascular permeability in mice. However, this effect was lower than this of indomethacin. The inhibition effect exerted by ZVE was not significant.

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“…There are few studies concerning the traditional use of this plant. However, biological and pharmacological studies have shown that the essential oil of V. arborea (VAEO) presents antimicrobial [14], anti-inflammatory [20], and gastroprotective activity [21]. The present study characterized the essential oil of Vanillosmopsis arborea chemically and evaluated its leishmanicidal and cytotoxic activity.…”

Section: Introductionmentioning

confidence: 99%

In VitroAntileishmanial Activity of Essential Oil ofVanillosmopsis arborea(Asteraceae) Baker

Colares

Almeida-Souza

Taniwaki

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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The search for new immunopharmacological chemical agents to treat various diseases caused by bacteria, fungi, and protozoa, such as leishmaniasis, for example, has led to the exploration of potential products from plant species and their main active ingredients. Antimonial drugs are the current treatment for leishmaniasis. These drugs cause major side effects and frequent discontinuation of treatment. In this study, we evaluated the in vitro leishmanicidal activity of essential oil of Vanillosmopsis arborea (VAEO) and its major compound α-bisabolol against Leishmania amazonensis. The essential oil and α-bisabolol showed activity against promastigotes (IC50 7.35 and 4.95 μg/mL resp.) and intracellular amastigotes (IC50 12.58 and 10.70 μg/mL, resp.). Neither product showed any cytotoxicity on treated macrophages. The ultrastructural analysis of promastigotes incubated with VAEO or α-bisabolol at 30 μg/mL, showed morphological changes with the accumulation of vesicles electrodense lipid inclusions. The results give evidence that both VAEO and α-bisabolol have potential as new therapeutic agents against leishmaniasis.

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Modulation of topical inflammation and visceral nociception by Vanillosmopsis arborea essential oil in mice

Cited by 12 publications

References 31 publications

LASSBio-1586, an N-acylhydrazone derivative, attenuates nociceptive behavior and the inflammatory response in mice

LASSBio-1586, an N-acylhydrazone derivative, attenuates nociceptive behavior and the inflammatory response in mice

Antioxidant and Anti-Inflammatory Activities of Rubus Fruticosus and Zizyphus Vulgaris Methanol Extracts

In VitroAntileishmanial Activity of Essential Oil ofVanillosmopsis arborea(Asteraceae) Baker

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