In VitroAntileishmanial Activity of Essential Oil ofVanillosmopsis arborea(Asteraceae) Baker

Colares, Aracélio Viana; Almeida-Souza, Fernando; Taniwaki, Noemi Nosomi; Souza, Celeste da Silva Freitas de; Costa, José Galberto Martins da; Calabrese, Kátia da Silva; Abreu-Silva, Ana Lúcia

doi:10.1155/2013/727042

Cited by 43 publications

(41 citation statements)

References 39 publications

(45 reference statements)

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“…promastigotes or axenic amastigotes. 28 Recently, Colares et al evaluated (−)-α-bisabolol, 29 alone and as an essential oil constituent, against Leishmania amazonensis intracellular amastigotes in a peritoneal macrophage model. Those results, in terms of potency (IC 50 48 μM), only slightly differed from those obtained in this investigation, and this difference may result from the differences between the in vitro models used.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

(−)-α-Bisabolol, a Promising Oral Compound for the Treatment of Visceral Leishmaniasis

et al. 2015

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The aim of the present study was to assess the in vitro and in vivo activity of (-)-α-bisabolol (1) against the etiological agents of visceral leishmaniasis. Bone-marrow-derived macrophages were infected with Leishmania infantum or L. donovani promastigotes and incubated with (-)-α-bisabolol at different concentrations. Pentamidine isethionate and meglumine antimoniate were used as reference drugs. Inhibitory concentration 50% (IC50) and cytotoxic concentration 50% (CC50) were calculated. Balb/c mice were infected intraperitoneally with stationary-phase promastigotes. They were treated with (-)-α-bisabolol at different doses orally, meglumine antimoniate at 104 mg Sb(V)/kg, or a combination of both. (-)-α-Bisabolol proved to be innocuous to mammal cells and active against L. infantum and L. donovani intracellular amastigotes (IC50 55 and 39 μM, respectively). Compound 1 also proved to be active in an in vivo model of visceral leishmaniasis due to L. infantum, as it reduced parasite load in the spleen and liver by 71.60% and 89.22%, respectively, at 200 mg/kg without showing toxicity. (-)-α-Bisabolol (1) is a nontoxic compound that was proven to be active against visceral leishmaniasis in an in vivo murine model orally. It was more effective than meglumine antimoniate at reducing spleen parasite load and as effective as this antimonial drug in the liver.

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Section: ■ Results and Discussionmentioning

confidence: 99%

(−)-α-Bisabolol, a Promising Oral Compound for the Treatment of Visceral Leishmaniasis

et al. 2015

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“…Our in vitro results in amastigotes also revealed better activity than other EOs obtained from Cuban plants, including Artemisia absinthium L. (Asteraceae), IC 50 = 13.4 μg/mL (Monzote et al ., ), and Bixa orellana L. (Bixaceae) IC 50 = 8.5 μg/mL (Monzote et al ., 2014 b). In addition, a lower IC 50 value was also obtained than some EOs reported in the literature: Croton cajucara Benth (Euphorbiaceae), IC 50 = 66.7 μg/mL (Rodrigues et al ., ); Lippia sidoides Cham (Verbenaceae), IC 50 = 44 μg/mL (de Medeiros et al ., ); Vanillosmopsis arborea Baker (Asteraceae), IC 50 = 12.6 μg/mL (Colares et al ., ); Aristolochia cymbifera Mart (Aristolochiaceae); Lippia alba (Mill.) N.E.Br.…”

Section: Discussionmentioning

confidence: 97%

“…However, to our knowledge, no previous reports have appeared regarding the antileishmanial activity of EO from P. carolinensis. Nevertheless, potentialities of EOs have been widely demonstrated against Leishmania parasites (de Medeiros et al, 2011;Monzote et al, 2014 a b;Colares et al, 2013;Monzote et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

“…It is estimated that about 25% of medicines are derived directly or indirectly from herbal products (Kunle et al ., ). Within the group of natural products, essential oils (EOs) have been of interest because of their broad spectrum of reported biological properties (Kulevanova et al ., ; Rhayour et al ., ), including leishmanicidal activity (de Medeiros et al ., ; Rodrigues et al ., ; Colares et al ., ; Monzote et al ., ,b). In addition, their hydrophobic nature makes these oils more permeable to cells (Burt, ), which is a very important feature for developing agents against intracellular pathogens.…”

Section: Introductionmentioning

confidence: 99%

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Chemical Characterization, Antileishmanial Activity, and Cytotoxicity Effects of the Essential Oil from Leaves of Pluchea carolinensis (Jacq.) G. Don. (Asteraceae)

García

Scull

Satyal

et al. 2017

Phytotherapy Research

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Current strategies to control leishmaniasis are mainly based on chemotherapy. However, none of the available drugs can be considered to be ideal to treat this disease. Because of the hydrophobic nature and bioactivities of their components, essential oils (EOs) can be considered as important sources for developing agents against intracellular pathogens, such as Leishmania parasites. In this study, we report the chemical characterization, antileishmanial activities, and cytotoxicity effect of the EO from Pluchea carolinensis (Jacq.) G. Don. (Asteraceae). Chemical analysis revealed that EO from aerial part from P. carolinensis is composed of 44 compounds. The main component was selin-11-en-4α-ol, which made up 51.0%. In vitro antileishmanial studies showed that P. carolinensis EO inhibited the growth of promastigotes (IC = 24.7 ± 7.1 μg/mL) and amastigotes (IC = 6.2 ± 0.1 μg/mL) of Leishmania amazonensis, while cytotoxicity evaluation revealed fivefold higher values than those for the parasites. In a model of experimental cutaneous leishmaniasis in BALB/c mice, five doses of EO at 30 mg/kg by intralesional route demonstrated smaller lesion size and parasite burden (p < 0.05) compared with animals treated with Glucantime® and untreated mice. In conclusion, in vitro and in vivo results showed the potentialities of EO from P. carolinensis with the future possibility of a new alternative in the treatment for leishmaniasis. Copyright © 2017 John Wiley & Sons, Ltd.

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“…Plant natural products have been used in the treatment of infectious diseases, especially in developing countries [11], with some displaying antileishmanial activities [12]. These activities have been attributed to the flavonoids, phenylpropanoids, steroids, quinones, chalcones and a few more, but the most listed in reviews are alkaloids and terpenes [10,12].To date, a list of compounds from plants which have entered investigational stage had been summarized by Sundar and Chakravarty [13] which includes amarogentin from Swertia chirata, maesabalide III triterpenoide saponins from Maesa balansae, prenyloxy-naphthoquinone from Plubago zeylanica, plumbagin from Pera benensis and a list of 2-substituted quinaline alkaloids derived from Galipea longiflora.…”

Section: Introductionmentioning

confidence: 99%

(+)-Spectaline, a Piperidine Alkaloid from Senna spectabilis DC. Effective in Reducing the In Vitro Infection of Leishmania major

Sain

Amanah

Zahari

et al. 2016

IJPPE

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Senna spectabilis is known to have antimicrobial, laxative, antiulcerogenic, analgesic, and anti-inflammatory properties in folk medicine. Piperidine alkaloids extracted from various parts of this plant have been shown to have anticonvulsant (iso-6-spectaline), antinociceptive [(-)-spectaline] and lipid peroxidation [(+)-3-O-feruloylcassine, (-)-spectaline and (-)-3-O-acetylspectaline] activities. In our study, the ethyl acetate extract from S. spectabilis exhibited antileishmanial activity via intracellular promastigote assay or leishmanicidal assay and was further fractionated by using bioassay-guided isolation approach. The antiprotozoal principle was isolated from the ethyl acetate portion through solvent fractionation and a few series of chromatographic processes. The isolated active compound 1 was identified as (+)-spectaline on the basis of its spectral analysis (MS, 1D & 2D NMR) with EC50 value of 0.063 ± 0.005 µM for antileishmanial activity and selectivity index of 3.76.

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In VitroAntileishmanial Activity of Essential Oil ofVanillosmopsis arborea(Asteraceae) Baker

Cited by 43 publications

References 39 publications

(−)-α-Bisabolol, a Promising Oral Compound for the Treatment of Visceral Leishmaniasis

(−)-α-Bisabolol, a Promising Oral Compound for the Treatment of Visceral Leishmaniasis

Chemical Characterization, Antileishmanial Activity, and Cytotoxicity Effects of the Essential Oil from Leaves of Pluchea carolinensis (Jacq.) G. Don. (Asteraceae)

(+)-Spectaline, a Piperidine Alkaloid from <i>Senna spectabilis</i> DC. Effective in Reducing the <i>In Vitro</i> Infection of <i>Leishmania major</i>

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