Modulation of the resorption and osteoconductivity of α-calcium sulfate by histone deacetylase inhibitors

Synergistic effects of dimethyloxalylglycine and butyrate incorporated into α-calcium sulfate on bone regeneration

“…# Significantly different from the groups treated with DMOG or butyrate alone (p < 0.05). [20], and the PHD inhibitor DMOG to promote angiogenesis. PHD inhibitors have been suggested as alternatives to angiogenic growth factors for enhancing the healing of soft and hard tissues [9,10,14,37].…”

“…Since aCS is osteoconductive, the addition of the small molecules to aCS may produce a synergistic effect on bone regeneration, with few undesirable side effects. In a previous study, we showed that aCS was an efficient vehicle for delivering HDAC inhibitors to defect sites and features of systemic adverse effect were not observed [20]. In this study, based on our previous studies and the literature cited above, we examined the effects of the combined delivery of DMOG, a PHD inhibitor, and butyrate, a HDAC inhibitor, on bone regeneration.…”

“…Previously, we found that butyrate incorporated into aCS enhanced osteoblast differentiation and bone healing [20]. In this study, we examined the effects of DMOG embedded in aCS and the additional incorporation of butyrate in aCS/DMOG on bone healing.…”

“…In bone cells, HDAC inhibitors have been reported to promote osteoblast maturation and to induce the differentiation of mesenchymal stem cell into osteoblasts [18,19]. Previously, we demonstrated that HDAC inhibitors enhance osteoblast differentiation and bone healing through in vivo and in vitro experiments [20] and exhibit some features of anti-inflammatory effects [21]. Therefore, it is likely that HDAC inhibitors are promising candidate small molecules for applications in bone tissue engineering, especially for inflammatory bone defects [16,20e22].…”

Polymer Composites for Bone Reconstruction

“…Actually, plain CaSO 4 -based cements disappear from the body in one year (Jung et al, 2010). Therefore, CaSO 4 cements are utilized as bone graft substitute in reconstruction in the distal radius.…”