Modulation of the Intestinal Microbiota by the Early Intervention with Clostridium Butyricum in Muscovy Ducks

Xiao, Xingning; Fu, Zixian; Li, Na; Yang, Hua; Wang, Wen; Lyu, Wentao

doi:10.3390/antibiotics10070826

Cited by 5 publications

(6 citation statements)

References 38 publications

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“…Some studies have shown that changes in the intestinal flora can affect intestinal health ( 58 ), and the cecal microbiota composition significantly impacts the growth and health of poultry ( 59 , 60 ). A study found that the addition of Clostridium butyricum to the feeds of early Muscovy ducks improved the cecal microflora richness ( 61 ). In this study, we found that CSB supplementation increased the Chao1, Shannon, and Pielou-e indices in laying ducks, suggesting higher cecal microflora richness and diversity in the group CSB compared to the control group.…”

Section: Discussionmentioning

confidence: 99%

Dietary supplementation of coated sodium butyrate improves growth performance of laying ducks by regulating intestinal health and immunological performance

Zeng

Sun²,

Huang³

et al. 2023

Front. Immunol.

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IntroductionThis study was conducted to assess the effects of dietary supplementation of coated sodium butyrate (CSB) on the growth performance, serum antioxidant, immune performance, and intestinal microbiota of laying ducks.MethodsA total of 120 48-week-old laying ducks were randomly divided into 2 treatment groups: the control group (group C fed a basal diet) and the CSB-treated group (group CSB fed the basal diet + 250 g/t of CSB). Each treatment consisted of 6 replicates, with 10 ducks per replicate, and the trial was conducted for 60 days.ResultsCompared with the group C, the group CSB showed a significant increase in the laying rate (p<0.05) of the 53-56 week-old ducks. Additionally, the serum total antioxidant capacity, superoxide dismutase activity and immunoglobulin G level were significantly higher (p<0.05), while the serum malondialdehyde content and tumor necrosis factor (TNF)-a level were significantly lower (p<0.05) in the serum of the group CSB compared to the group C. Moreover, the expression of IL-1b and TNF-a in the spleen of the group CSB was significantly lower (p<0.05) compared to that of the group C. In addition, compared with the group C, the expression of Occludin in the ileum and the villus height in the jejunum were significantly higher in the group CSB (p<0.05). Furthermore, Chao1, Shannon, and Pielou-e indices were higher in the group CSB compared to the group C (p<0.05). The abundance of Bacteroidetes in the group CSB was lower than that in the group C (p<0.05), while the abundances of Firmicutes and Actinobacteria were higher in the group CSB compared to the group C (p<0.05).ConclusionsOur results suggest that the dietary supplementation of CSB can alleviate egg-laying stress in laying ducks by enhancing immunity and maintaining the intestinal health of the ducks.

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Section: Discussionmentioning

confidence: 99%

Dietary supplementation of coated sodium butyrate improves growth performance of laying ducks by regulating intestinal health and immunological performance

Zeng

Sun²,

Huang³

et al. 2023

Front. Immunol.

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“…In recent years, intestinal microbes have often been mentioned, and research on intestinal microbes and the growth performance of livestock and poultry has gradually been conducted [ 33 , 34 , 35 ]. Studies by Xiao et al (2021) found that Clostridium butyricum can improve Muscovy duck growth performance [ 26 ]. In addition, Gong et al (2019) also mentioned that Bacteroides can improve the growth performance of poultry [ 27 ], showing that intestinal microbes also have a growth-promoting effect.…”

Section: Discussionmentioning

confidence: 99%

“…We speculate that this may be because BMD intervention is extremely related to the effect of Gram-positive bacteria [ 14 ] but has no effect on the overall species diversity. Xiao et al (2021) found that Clostridium butyricum intervention in Muscovy ducks at different growth stages can change the structure of intestinal flora [ 26 ]. Proctor et al (2019) found that BMD intervention can change the microbial structure in the colon and caecum [ 14 ], and Adewole et al (2021) found that BMD intervention can change the microbial structure in the caecum [ 36 ].…”

Section: Discussionmentioning

confidence: 99%

“…Predecessors found through the technique of faecal microbiota transplantation that the growth performance of calves after faecal microbiota transplantation was significantly increased [ 21 ], which shows that the growth performance of gut microbiota is improved, but the mechanism of action is still unclear. Additionally, the research team found in the early stage that the addition of Clostridium butyricum to the diet can significantly improve the growth of Muscovy ducks [ 26 ], and that the gut microbiota can also improve the growth performance of broilers [ 27 ]. Therefore, the structure of the gut microbiota changes, which leads to changes in production performance.…”

Section: Introductionmentioning

confidence: 99%

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Dietary Bacitracin Methylene Disalicylate Improves Growth Performance by Mediating the Gut Microbiota in Broilers

Xiao

Fan

et al. 2022

Antibiotics

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The growth performance of livestock and poultry has always been a concern. However, much work is currently focused on the selection of breeds and diets to improve the growth performance of livestock and poultry. Furthermore, numerous studies have shown that the gut microbiota is closely related to the growth performance of livestock and poultry. At present, there are many reports on the impact of antibiotic intervention on the structure of gut microbiota. However, there are few reports on the influence of antibiotic intervention on the structure of intestinal microbes and the effect of this change on growth performance. Bacitracin methylene disalicylate (BMD) intervention changes the microbial structure in the caecum of broilers at different growth stages, as shown in this study. To further reveal the potential relationship between gut microbiota changes and growth performance caused by BMD intervention, correlation analysis was used for analysis. A total of 144 1-day-old male Cobb-Vantress were randomly divided into two groups. In addition to antibiotic-free starter mash diets, starter mash diets supplemented with 55 mg/kg BMD were also used, called the CON group and the BMD group, and lasted 28 days. (1) These study results showed that adding BMD to the diet had a significant effect on the growth performance of broilers. Compared with the CON group, the body weight of the BMD group increased significantly by 11.08% and 20.13% on Days 14 and 28, respectively (p < 0.05). Similarly, at 0–14, 14–28 and 0–28 days of age, the average daily gain of the BMD group increased significantly by 12.28%, 24.49% and 20.80%, respectively. The average daily feed intake of the BMD group increased significantly by 18.28%, 27.39% and 24.97% (p < 0.05). In addition, at 0–28 days of age, the feed conversion ratio increased significantly by 5.5% (p < 0.05). (2) Alpha diversity results show that BMD intervention has an impact on gut microbiota at different growth stages. (3) The early intervention significantly affected 7 taxa by Day 14, followed by 22 taxa by Day 28, which is similar to the results in the caecal flora. Compared with the CON group, the Christensenellaceae R-7 group had the highest linear discriminant analysis (LDA) score on Day 28. In addition, Pearson’s correlation analysis showed that the Lachnospiraceae FCS020 group was significantly negatively correlated with growth performance. In general, these results indicate that dietary supplementation of BMD has an effect on broiler gut microbiota structure and growth performance. However, changes in growth performance may be caused by the gut microbiota structure.

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“…Supplementing feed with C. butyricum improved the growth performance and feed efficiency in poultry production [ 25 , 26 , 27 ]. Similarly, the addition of C. butyricum in the feed has been proven to prompt the growth performance of weaned piglets [ 28 , 29 , 30 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of Clostridium butyricum as an Antibiotic Alternative on Growth Performance, Intestinal Morphology, Serum Biochemical Response, and Immunity of Broilers

Yang

Zhang

et al. 2023

Antibiotics

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The current study aimed to investigate the effects of Clostridium butyiricum on growth performance, intestinal morphology, serum biochemical response, and immunity in broiler chickens. A total of 330 commercial one-day-old, mixed-sex Ross 308 broilers were randomly divided into five treatment groups with six replicates per group. The broilers were fed the basal diet (CON), the basal diet with 150 mg/kg of aureomycin (AM), the basal diet with C. butyricum at 2 × 108 CFU/kg (CBL), the basal diet with C. butyricum at 4 × 108 CFU/kg (CBM), and the basal diet with C. butyricum at 8 × 108 CFU/kg (CBH). Results showed that the final body weight (BW) (p < 0.01; p < 0.05), ADG from day 22 to 39 (p < 0.05), and ADG from day 1 to 39 (p < 0.01; p < 0.05) were improved in a linear and quadratic response with the inclusion of C. butyricum. There were no differences in feed conversion rate (FCR) among all groups (p > 0.05). Supplementation with C. butyricum quadratically reduced the crypt depth at day 21 (p < 0.01), linearly improved the villus height in the jejunum at day 39 (p < 0.001), and linearly and quadratically increased the villus height to crypt depth (V/C) ratio in the jejunum at day 21 (p < 0.01) and day 39 (p < 0.01; p < 0.001). Dietary C. butyricum affected the thymus index at day 21 and day 39 (linear, p < 0.01), and the bursa of Fabricius index at day 39 (quadratic, p < 0.05). Compared to the AM group, the serum urea contents were decreased (p < 0.05) but the IgG contents were increased in the CBL and CBH groups at day 21 (p < 0.01); in addition, serum albumin (ALB) concentrations in all the C. butyricum-supplemented groups (p < 0.01) and IgG concentrations in the CBM group were augmented at day 39 (p < 0.05). In conclusion, dietary C. butyricum could enhance growth performance by improving jejunal morphology and stimulating immunity organ development in broilers, and could be an alternative to antibiotics in poultry feeds.

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Modulation of the Intestinal Microbiota by the Early Intervention with Clostridium Butyricum in Muscovy Ducks

Cited by 5 publications

References 38 publications

Dietary supplementation of coated sodium butyrate improves growth performance of laying ducks by regulating intestinal health and immunological performance

Dietary supplementation of coated sodium butyrate improves growth performance of laying ducks by regulating intestinal health and immunological performance

Dietary Bacitracin Methylene Disalicylate Improves Growth Performance by Mediating the Gut Microbiota in Broilers

Effects of Clostridium butyricum as an Antibiotic Alternative on Growth Performance, Intestinal Morphology, Serum Biochemical Response, and Immunity of Broilers

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