Dietary supplementation of coated sodium butyrate improves growth performance of laying ducks by regulating intestinal health and immunological performance

Abstract

IntroductionThis study was conducted to assess the effects of dietary supplementation of coated sodium butyrate (CSB) on the growth performance, serum antioxidant, immune performance, and intestinal microbiota of laying ducks.MethodsA total of 120 48-week-old laying ducks were randomly divided into 2 treatment groups: the control group (group C fed a basal diet) and the CSB-treated group (group CSB fed the basal diet + 250 g/t of CSB). Each treatment consisted of 6 replicates, with 10 ducks per replicate, and the trial was conducted for 60 days.ResultsCompared with the group C, the group CSB showed a significant increase in the laying rate (p<0.05) of the 53-56 week-old ducks. Additionally, the serum total antioxidant capacity, superoxide dismutase activity and immunoglobulin G level were significantly higher (p<0.05), while the serum malondialdehyde content and tumor necrosis factor (TNF)-a level were significantly lower (p<0.05) in the serum of the group CSB compared to the group C. Moreover, the expression of IL-1b and TNF-a in the spleen of the group CSB was significantly lower (p<0.05) compared to that of the group C. In addition, compared with the group C, the expression of Occludin in the ileum and the villus height in the jejunum were significantly higher in the group CSB (p<0.05). Furthermore, Chao1, Shannon, and Pielou-e indices were higher in the group CSB compared to the group C (p<0.05). The abundance of Bacteroidetes in the group CSB was lower than that in the group C (p<0.05), while the abundances of Firmicutes and Actinobacteria were higher in the group CSB compared to the group C (p<0.05).ConclusionsOur results suggest that the dietary supplementation of CSB can alleviate egg-laying stress in laying ducks by enhancing immunity and maintaining the intestinal health of the ducks.

Effects of coated sodium butyrate on the growth performance, serum biochemistry, antioxidant capacity, intestinal morphology, and intestinal microbiota of broiler chickens

“…Our findings are in line with previous studies. Zeng et al (2023) , reported a slight reduction in ADFI in ducks with the addition of CSB, confirming our results. Additionally, Zhang et al (2022) , demonstrated that the inclusion of 800 mg/kg CSB in the feed significantly improved FCR, with no significant effect on ADFI.…”

“…Research by Miao et al (2023 ), demonstrated that the addition of CSB to feed effectively increases the content of GSH-Px and T-AOC, while reducing MDA levels. Additionally, the research conducted by Zeng et al (2023) , also indicates that the addition of CSB can effectively enhance the serum antioxidant capacity of laying ducks. In line with these findings, our study revealed that the addition of CSB significantly increased the levels of SOD, CAT, and T-AOC in the serum of broiler chickens, providing compelling evidence for the beneficial effects of CSB in enhancing the serum antioxidant capacity of yellow-feathered broilers.…”

Sodium Butyrate Alleviates Free Fatty Acid-Induced Steatosis in Primary Chicken Hepatocytes via Regulating the ROS/GPX4/Ferroptosis Pathway

“…Additionally, Li L. et al demonstrated that NaB ameliorates lipopolysaccharides-induced oxidative damage by upregulating the activities of antioxidative enzymes and reducing protein damage in MAC-T cells [31]. Additionally, the dietary supplementation of NaB can alleviate egg-laying stress in laying ducks by enhancing antioxidant ability [32]. The surplus of hepatic lipids can lead to alterations in cellular redox status, cumulating oxidative harm to biomacromolecules such as DNA, lipids, and proteins.…”