Modulation of the fungal mycobiome is regulated by the chitin-binding receptor FIBCD1

Møeller, Jesper Bonnet; Leonardi, Irina; Schlosser, Anders; Flamar, Anne-Laure; Bessman, Nicholas J.; Putzel, Gregory G.; Thomsen, Theresa; Hammond, Mark A.; Jepsen, Christine Schoeler; Skjødt, Karsten; Füchtbauer, Ernst‐Martin; Farber, Donna L.; Sørensen, Grith Lykke; Iliev, Iliyan D.; Holmskov, Uffe; Artis, David

doi:10.1084/jem.20182244

Cited by 24 publications

(33 citation statements)

References 57 publications

(91 reference statements)

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“…Another informative piece of evidence about the functions of FIBCD1 comes from our recent report by Moeller et al 44 By generating mice overexpressing FIBCD1 specifically in intestinal epithelial cells, we established that FIBCD1 selectively regulates the composition and abundance of commensal gut‐resident fungi. Transgenic FIBCD1 mice were also more resistant to fungal colonization with the mouse‐prevalent Candida spp.…”

Section: Fibcd1mentioning

confidence: 91%

Fungal recognition by mammalian fibrinogen‐related proteins

Pilecki

Møeller

2020

Scand J Immunol

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Fungi are ubiquitous eukaryotic microorganisms present in virtually all environmental habitats. Although rarely pathogenic to the healthy population, many fungal species are capable of causing human disease in immunocompromised individuals. Thus, fungal infections remain a significant cause of morbidity and mortality, with rising prevalence accompanying the worldwide increase in immunosuppressionbased therapies. Therefore, better understanding of the mutual interactions between the protective host mechanisms and the invading fungi remains of critical importance. The innate immune system constitutes the first line of defence against exogenous insults. The innate antifungal immunity is mediated through recognition of specific pathogen-associated molecular patterns (PAMPs) by a broad panel of host pattern recognition receptors (PRRs), responsible for mounting adequate protective responses. In this review, we describe fungal PAMPs as well as a selection of PRRs able to recognize them. We focus on the members of the fibrinogen-related domain (FReD) protein family that have been shown to recognize fungi-derived molecules: ficolins, fibrinogen C domain containing 1 (FIBCD1) and tenascin-C. We describe their structure, their binding targets and their established as well as putative biological functions related to fungal recognition and immunity. F I G U R E 1 The fungal cell wall and exposure of PAMPs during fungal cell transitions. A, Schematic representation of the fungal cell wall. The outer cell wall primarily composed of mannoproteins (blue) shields the inner cell wall composed of glucans (red) and chitin (yellow) from recognition by host immunity. B, Schematic representation of fungal yeast cell division. During fungal cell division and in budding scars after division, the inner cell wall components (glucans and chitin) are exposed to the environment and can be recognized by the host. C, Representation of conidia, germination and growth of germ tubes. During germination (swollen conidia) and formation of germ tubes, the inner cell wall components are exposed to the environment and can be recognized by the host. D, Schematic representation of filamentous growth of hyphaeforming fungi. During formation and growth of hyphae, the inner cell wall components may be exposed to the environment and potentially recognized by the host How to cite this article: Pilecki B, Moeller JB. Fungal recognition by mammalian fibrinogen-related proteins.

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Section: Fibcd1mentioning

confidence: 91%

Fungal recognition by mammalian fibrinogen‐related proteins

Pilecki

Møeller

2020

Scand J Immunol

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“…73 Receptors expressed on cells outside of the immune system, such as ERBB2, EGFR, EPHA2, FIBCD1, and MelLec, contribute to the antifungal immune response at mucosal surfaces, with less clear roles in the gut (Figure 2). [74][75][76][77][78] In addition to receptor-mediated antifungal responses, C albicans can directly damage oral and vaginal epithelium via the toxin candidalysin, resulting in production of inflammatory cytokines. 79,80 Candidalysin has been reported to damage human epithelial colorectal adenocarcinoma cells, 81 justifying further exploration of the effects of this toxin in the gut.…”

Section: Effects Of Fungi On the Immune Responsementioning

confidence: 99%

Effects of Intestinal Fungi and Viruses on Immune Responses and Inflammatory Bowel Diseases

Iliev

Cadwell

2021

Gastroenterology

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The intestinal microbiota comprises diverse fungal and viral components, in addition to bacteria. These microbes interact with the immune system and affect human physiology. Advances in metagenomics have associated inflammatory and autoimmune diseases with alterations in fungal and viral species in the gut. Studies of animal models have found that commensal fungi and viruses can activate hostprotective immune pathways related to epithelial barrier integrity, but can also induce reactions that contribute to events associated with inflammatory bowel disease. Changes in our environment associated with modernization and the COVID-19 pandemic have exposed humans to new fungi and viruses, with unknown consequences. We review the lessons learned from studies of animal viruses and fungi commonly detected in the human gut and how these might affect health and intestinal disease.

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“…Further, inflammatory cytokine production is suppressed by FIBCD1-mediated mechanisms in lung epithelial cells [35]. Epithelial cell-specific FIBCD1-transgenic mice showed decreased fungal infection and impaired fungal-driven inflammatory responses in the intestine [36]. The cell components are mainly divided into cell walls and intracellular components, and there are various pattern recognition receptors and their downstream signaling pathways.…”

Section: Pattern Recognition For Il-17 Induction Against Fungimentioning

confidence: 99%

The Role of IL-17-Producing Cells in Cutaneous Fungal Infections

Sawada

Setoyama

Sakuragi

et al. 2021

IJMS

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The skin is the outermost layer of the body and is exposed to many environmental stimuli, which cause various inflammatory immune responses in the skin. Among them, fungi are common microorganisms that colonize the skin and cause cutaneous fungal diseases such as candidiasis and dermatophytosis. The skin exerts inflammatory responses to eliminate these fungi through the cooperation of skin-component immune cells. IL-17 producing cells are representative immune cells that play a vital role in anti-fungal action in the skin by producing antimicrobial peptides and facilitating neutrophil infiltration. However, the actual impact of IL-17-producing cells in cutaneous fungal infections remains unclear. In this review, we focused on the role of IL-17-producing cells in a series of cutaneous fungal infections, the characteristics of skin infectious fungi, and the recognition of cell components that drive cutaneous immune cells.

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Modulation of the fungal mycobiome is regulated by the chitin-binding receptor FIBCD1

Cited by 24 publications

References 57 publications

Fungal recognition by mammalian fibrinogen‐related proteins

Fungal recognition by mammalian fibrinogen‐related proteins

Effects of Intestinal Fungi and Viruses on Immune Responses and Inflammatory Bowel Diseases

The Role of IL-17-Producing Cells in Cutaneous Fungal Infections

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