Modulation of Superoxide Dismutase Activity by Mercury, Lead, and Arsenic

Kumar, Abhishek; Khushboo, .; Pandey, Rukmani; Sharma, Bechan

doi:10.1007/s12011-019-01957-3

Cited by 34 publications

(18 citation statements)

References 29 publications

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“…For instance, heavy metals, such as mercury, arsenic and lead, induce oxidative stress by promoting the production of ROS and reactive nitrogen species (RNS). These metals may replace the transition metals, such as Zn and Cu, which are required for SOD catalytic function, and inhibit their function [13]. Various chemicals can affect the balance between pro-oxidant challenge and antioxidant defenses by enhancing ROS and/or RNS formation and by depressing their removal [116].…”

Section: Sod As a Detoxification Strategymentioning

confidence: 99%

“…Based on 28 out of 144 article studies on several different hypertensive animal models that were published between July 1998 and December 2012, tempol treatment has been demonstrated to be beneficial for mean arterial pressure [268]. Diminished SOD activity has been identified as a risk factor for stroke, hypertension, hypercholesterolemia, atherosclerosis, heart failure and other cardiovascular diseases [13], including coronary artery disease [269].…”

Section: Cardiovascular Diseasesmentioning

confidence: 99%

“…On this basis, it is universally recognized that SOD is the first line of defense against the toxicity of • O 2 − because catalyzing the dismutation of two molecules of • O 2 − to hydrogen H 2 O 2 and O 2 limits the • O 2 − availability. Low and diminished SOD activity has been associated with a significant risk of oxidative stress, resulting in disease, such as hypertension, hypercholesterolemia, atherosclerosis, diabetes, heart failure, stroke and other cardiovascular diseases [12,13]. Therefore, it has been suggested that the antioxidant properties of SOD supplementation are useful in a variety of pathophysiological conditions, from protecting the immune system to the prevention of aging [14].…”

Section: Introductionmentioning

confidence: 99%

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Superoxide Dismutase Administration: A Review of Proposed Human Uses

et al. 2021

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Superoxide dismutases (SODs) are metalloenzymes that play a major role in antioxidant defense against oxidative stress in the body. SOD supplementation may therefore trigger the endogenous antioxidant machinery for the neutralization of free-radical excess and be used in a variety of pathological settings. This paper aimed to provide an extensive review of the possible uses of SODs in a range of pathological settings, as well as describe the current pitfalls and the delivery strategies that are in development to solve bioavailability issues. We carried out a PubMed query, using the keywords “SOD”, “SOD mimetics”, “SOD supplementation”, which included papers published in the English language, between 2012 and 2020, on the potential therapeutic applications of SODs, including detoxification strategies. As highlighted in this paper, it can be argued that the generic antioxidant effects of SODs are beneficial under all tested conditions, from ocular and cardiovascular diseases to neurodegenerative disorders and metabolic diseases, including diabetes and its complications and obesity. However, it must be underlined that clinical evidence for its efficacy is limited and consequently, this efficacy is currently far from being demonstrated.

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Section: Sod As a Detoxification Strategymentioning

confidence: 99%

Section: Cardiovascular Diseasesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Superoxide Dismutase Administration: A Review of Proposed Human Uses

et al. 2021

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“…Lead and mercury may have decreased the activity of SOD by directly interacting with the -SH group of the enzyme leading to denaturation of the enzyme and subsequent decrease in activity observed in our study Al-Attar (2020); Zhao et al (2020); Kalantari et al (2007). Lead is highly deleterious and induces oxidative stress through dysregulation of SOD and catalase (Kumar et al, 2020;Fu and Xi, 2020;Farmand et al, 2005). Additionally, accumulation of these heavy metals in the hepatocyte may have led to their interaction with the amino-acids residue of these enzymatic antioxidants thereby inhibiting their activities.…”

Section: Discussionmentioning

confidence: 59%

“…(2007) . Lead is highly deleterious and induces oxidative stress through dysregulation of SOD and catalase ( Kumar et al., 2020 ; Fu and Xi, 2020 ; Farmand et al., 2005 ). Additionally, accumulation of these heavy metals in the hepatocyte may have led to their interaction with the amino-acids residue of these enzymatic antioxidants thereby inhibiting their activities.…”

Section: Discussionmentioning

confidence: 99%

Ethanol leaf extract of Psychotria microphylla rich in quercetin restores heavy metal induced redox imbalance in rats

Orji

Awoke

Harbor

et al. 2020

Heliyon

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Psychotria microphylla is a plant found in Africa and many parts of the world where the leaves are locally used in folk medicine for the treatment of toxicity related liver diseases. We investigated the antioxidant potentials of ethanol leaf extract of Psychotria microphylla (ELE-PM) in restoring hepatic redox dysregulations in rats exposed to heavy metals. HPLC was used in quantifying the bioactive compounds in ELE-PM. DPPH (1,1-diphenyl-2 picrylhydrazyl), FRAP (Ferric reducing antioxidant power) and NO (Nitric Oxide) assays were used for in vitro studies. The in vivo studies involved 30 rats randomly divided into 5 groups ( n = 6). Group 1 received normal saline (2 mg/kg), group 2, 3, 4 and 5 received a combined solution of Pb(NO 3 ) 2 (11.25 mg/kg) and HgCl 2 (0.4 mg/kg) respectively. After 7 days of heavy metal exposure, groups 3, 4 and 5 received a daily bolus administration of 200, 400 and 600 mg/kg body weight of EE-PM respectively through oral intubation for 28 days. HPLC quantification revealed a high amount of quercetin (27.43 ± 0.04 mg/100g), lower amounts of gallic acid (7.60 ± 0.06 mg/100g) and rutin (0.38 ± 0.009 mg/100g). Additionally, ELE-PM demonstrated strong inhibitory potentials against free radical scavenging activity generated in vitro . More interestingly, administration of ELE-PM significantly ameliorated hepatic redox dysregulations elicited by the exposure of the rats to heavy metals in a dose dependent pattern. ELE-PM is highly rich in flavonoid compound quercetin and perhaps this may be responsible for the strong antioxidant potentials exhibited in this investigation.

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Adverse Impact of Heavy Metals on Bone Cells and Bone Metabolism Dependently and Independently through Anemia

Zhang

Sun²,

Zhang

et al. 2020

Advanced Science

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Mounting evidence is revealing that heavy metals can incur disordered bone homeostasis, leading to the development of degenerative bone diseases, including osteoporosis, osteoarthritis, degenerative disk disease, and osteomalacia. Meanwhile, heavy metal-induced anemia has been found to be intertwined with degenerative bone diseases. However, the relationship and interplay among these adverse outcomes remain elusive. Thus, it is of importance to shed light on the modes of action (MOAs) and adverse outcome pathways (AOPs) responsible for degenerative bone diseases and anemia under exposure to heavy metals. In the current Review, the epidemiological and experimental findings are recapitulated to interrogate the contributions of heavy metals to degenerative bone disease development which may be attributable dependently and independently to anemia. A few likely mechanisms are postulated for anemia-independent degenerative bone diseases, including dysregulated osteogenesis and osteoblastogenesis, imbalanced bone formation and resorption, and disturbed homeostasis of essential trace elements. By contrast, remodeled bone microarchitecture, inhibited erythropoietin production, and disordered iron homeostasis are speculated to account for anemia-associated degenerative bone disorders upon heavy metal exposure. Together, this Review aims to elaborate available literature to fill in the knowledge gaps in understanding the detrimental effects of heavy metals on bone cells and bone homeostasis through different perspectives.

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Modulation of Superoxide Dismutase Activity by Mercury, Lead, and Arsenic

Cited by 34 publications

References 29 publications

Superoxide Dismutase Administration: A Review of Proposed Human Uses

Superoxide Dismutase Administration: A Review of Proposed Human Uses

Ethanol leaf extract of Psychotria microphylla rich in quercetin restores heavy metal induced redox imbalance in rats

Adverse Impact of Heavy Metals on Bone Cells and Bone Metabolism Dependently and Independently through Anemia

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