Modulation of sarcoplasmic/endoplasmic reticulum Ca2+-ATPase activity and oxidative modification during the development of adjuvant arthritis

Ca2+ signalling plays a role in celastrol‐mediated suppression of synovial fibroblasts of rheumatoid arthritis patients and experimental arthritis in rats

“…Apart from cellular activation, Ca 2+ flux is associated with synovial accumulation of autoantigen in RA patients by triggering the activation of peptidylarginine deiminase and subsequent citrullination of vimentin in macrophages (Vossenaar et al, ). In addition, conformational changes resulting in altered ATPase activity of SERCA1 have been reported in AIA rats which are correlated with the systemic inflammatory status of the animal model (Strosova et al, ). Such observations reinforce the idea of targeting Ca 2+ mobilization in cytoplasm or the balance of Ca 2+ homeostasis as an alternative therapeutic approach for improving RA.…”

Undernutrition Affects Cell Survival, Oxidative Stress, Ca2+ Handling and Signaling Pathways in Vas Deferens, Crippling Reproductive Capacity

“…These targets certainly include the active Ca 2+ transporters, which are subject to oxidative attack in processes associated with elevated levels of carbonylated proteins [37], as in the case encountered here (Figure 4B). It is of interest that carbonyl compounds have well-documented, specific effects on the male genital tract and testis of rats [38] and for that reason deserved special attention in this study, even though they only give a partial view of the redox state of a tissue.…”

Flavonoids in prevention of diseases with respect to modulation of Ca-pump function

“…We concluded that nitric oxide may regulate cytoplasmic Ca 2+ level through conformational alterations in the transmembrane Ca 2+ binding domain of SERCA (Strosova et al , 2011). …”