Flavonoids in prevention of diseases with respect to modulation of Ca-pump function

Horáková, Ľubica

doi:10.2478/v10102-011-0019-5

Cited by 43 publications

(26 citation statements)

References 76 publications

(102 reference statements)

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“…In vivo, mice studies have revealed that consumption of GT catechins may decrease the risk of atherosclerosis by improving the bioavailability of NO and by causing vasorelaxation, however, data appeasing this in humans is presently insufficient (Velayutham et al 2008). One study postulated that catechins could be the constituent responsible for their observed improvements in cell viability by reducing the intracellular Reactive Oxygen Species accumulation (Horáková 2011).…”

Section: Introductionmentioning

confidence: 99%

Assessing the effects of a short-term green tea intervention in skin microvascular function and oxygen tension in older and younger adults

Wasilewski

Ubara

Klonizakis

2016

Microvascular Research

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Green tea consumption has been associated with a reduction in cardiovascular disease risk factors. However, there is little evidence examining its potential differing effect between younger and older populations, whilst little is known on its effect on the circulatory system when oxygen demand is higher. Therefore the aim of this study was to evaluate the short-term effects of green tea consumption on microvascular functioning in both an older and younger population. Fifteen young [24 (4.0)] and fifteen older [61 (4.0)] participants, consumed two cups of green tea daily for 14days. We used Laser Doppler Flowmetry (LDF) to assess cutaneous microvascular function and Transcutaneous Oxygen monitoring (TcPO2) to assess skin oxygen tension. Systolic and diastolic blood pressure were also assessed on both visits. We observed significant improvements in axon-mediated microvascular vasodilation for the younger group [1.6 (0.59) vs 2.05 (0.72), p<0.05] and the older group [1.25 (0.58) vs 1.65 (0.5) p<0.05]. Improvements in skin oxygen tension were also noted for both groups in both noted TcPO2 measures (i.e. 1.25 (0.58) vs 1.65 (0.5) (p<0.05), for ΔTcPO2max for the older group, between visits) respectively. Improvements were also observed for systolic blood pressure in both the younger [120 (10) vs 112 (10), p<0.05] and older group [129 (12) v 124 (11), p<0.001]. In conclusion, we observed statistically-significant improvements in microvascular function and skin oxygen tension. Our results suggest that green tea may prove beneficial as a dietary element in lifestyle interventions aiming to lower cardiovascular disease risk, in both older and younger populations.

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Section: Introductionmentioning

confidence: 99%

Assessing the effects of a short-term green tea intervention in skin microvascular function and oxygen tension in older and younger adults

Wasilewski

Ubara

Klonizakis

2016

Microvascular Research

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“…[9] It is commonly known as scarlet mallow or midday flower in English. In India, decoction of leaves was drunk for inflammatory glands.…”

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confidence: 99%

Cerebroprotective activity of Pentapetes phoenicea on global cerebral ischemia in rats

Sravanthi

Rao

2016

Indian J Pharmacol

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Objectives:The study was performed to evaluate the cerebroprotective activity of methanolic extract (ME) of Pentapetes phoenicea - a folk medicine used as anti-inflammatory and in central nervous system ailments. It has high phenolic and flavonoid contents including rutin.Materials and Methods:Global cerebral ischemia was induced in male albino Wistar rats by temporary bilateral carotid artery occlusion (BCAO) for 30 min, followed by 4 h reperfusion. Groups of rats were pretreated for 10 days with 100, 200, and 400 mg/kg of ME of P. phoenicea and 3 mg/kg of edaravone, a marketed cerebroprotective agent, as standard. Antioxidant enzymes such as, the levels of malondialdehyde (MDA), glutathione peroxidase (GPx), glutathione reductase (GR), glutathione-S-transferase (GST), superoxide dismutase (SOD), catalase (CAT) and hydrogen peroxide (H2O2), protein content, brain water content, cerebral infarct size and the histopathological changes were measured.Results:P. phoenicea-pretreated groups restored the biochemical parameters significantly in a dose-dependent manner. The ischemic changes were involved with an increase in the concentration of MDA and H2O2, followed by decreased SOD, CAT, GPx, GR, and GST activity in rat brain. The neurodegenaration and its attenuation by P. phoenicea were confirmed by examination of triphenyl tetrazolium chloride staining and histopathological changes in the cerebral ischemic rat brains. Similarly, P. phoenicea reversed the brain water content in the ischemia-reperfusion animals.Conclusion:The result of the study indicates that the treatment with P. phoenicea enhances the antioxidant defense against BCAO-induced global cerebral ischemia/reperfusion and exerts cerebroprotection.

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“…Many bioactive compounds have been discovered from plants which have flavonoids, natural phenolic compounds, and phytoestrogens are strong antioxidant (Horáková, 2011; Yan et al, 2013). Fruits and vegetables which are enriched with higher content of flavonoid prevents the development of cardiovascular disease (Horáková, 2011).…”

Section: Introductionmentioning

confidence: 99%

“…Fruits and vegetables which are enriched with higher content of flavonoid prevents the development of cardiovascular disease (Horáková, 2011). Cardiac hypertrophy is inhibited by different antioxidants caused by ROS (Tsujimoto et al, 2005; Sheng, 2007).…”

Section: Introductionmentioning

confidence: 99%

Cardioprotective Effect of Ulmus wallichiana Planchon in β-Adrenergic Agonist Induced Cardiac Hypertrophy

et al. 2016

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Ulmus wallichiana Planchon (Family: Ulmaceae), a traditional medicinal plant, was used in fracture healing in the folk tradition of Uttarakhand, Himalaya, India. The present study investigated the cardioprotective effect of ethanolic extract (EE) and butanolic fraction (BF) of U. wallichiana in isoprenaline (ISO) induced cardiac hypertrophy in Wistar rats. Cardiac hypertrophy was induced by ISO (5 mg/kg/day, subcutaneously) in rats. Treatment was performed by oral administration of EE and BF of U. wallichiana (500 and 50 mg/kg/day). The blood pressure (BP) and heart rate (HR) were measured by non-invasive blood pressure measurement technique. Plasma renin, Ang II, NO, and cGMP level were estimated using an ELISA kit. Angiotensin converting enzyme activity was estimated. BP and HR were significantly increased in ISO group (130.33 ± 1.67 mmHg vs. 111.78 ± 1.62 mmHg, p < 0.001 and 450.51 ± 4.90 beats/min vs. 347.82 ± 6.91 beats/min, respectively, p < 0.001). The BP and HR were significantly reduced (EE: 117.53 ± 2.27 mmHg vs. 130.33 ± 1.67 mmHg, p < 0.001, BF: 119.74 ± 3.32 mmHg vs. 130.33 ± 1.67 mmHg, p < 0.001); HR: (EE: 390.22 ± 8.24 beats/min vs. 450.51 ± 4.90 beats/min, p < 0.001, BF: 345.38 ± 6.79 beats/min vs. 450.51 ± 4.90 beats/min, p < 0.001) after the treatment of EE and BF of U. wallichiana, respectively. Plasma renin, Ang II, ACE activity was decreased and NO, cGMP level were increased. The EE and BF of U. wallichiana down regulated the expression of ANP, BNP, TNF-α, IL-6, MMP9, β1-AR, TGFβ1 and up regulated NOS3, ACE2 and Mas expression level, respectively. Thus, this study demonstrated that U. wallichiana has cardioprotective effect against ISO induced cardiac hypertrophy.

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Flavonoids in prevention of diseases with respect to modulation of Ca-pump function

Cited by 43 publications

References 76 publications

Assessing the effects of a short-term green tea intervention in skin microvascular function and oxygen tension in older and younger adults

Assessing the effects of a short-term green tea intervention in skin microvascular function and oxygen tension in older and younger adults

Cerebroprotective activity of Pentapetes phoenicea on global cerebral ischemia in rats

Cardioprotective Effect of Ulmus wallichiana Planchon in β-Adrenergic Agonist Induced Cardiac Hypertrophy

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