Modulation of rat synaptosomal ATPases and acetylcholinesterase activities induced by chronic exposure to the static magnetic field

Dinčić, Marko; Krstić, Danijela; Čolović, Mirjana B.; Ostojic, Jelena Nesovic; Kovačević, Sanjin; Luka, Silvio R. De; Djordjević, Dejan; Ćirković, Saša; Brkić, Predrag; Todorović, Jovan

doi:10.1080/09553002.2018.1518611

Cited by 12 publications

(6 citation statements)

References 57 publications

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“…All of the evaluated studies were experimental animal studies as no human studies matched our eligibility criteria (see Table 1 for details). Various endpoints, including effects of exposure on melatonin biosynthesis [40,45], behavior [41,42], cardiovascular parameters [37,38,44,46], and brain and nervous system [39,43,47], were studied in rodents or birds. The size of the experimental groups varied between 3 and 50 animals and the applied magnetic flux densities ranged from 52 μT to 1 mT.…”

Section: Results Of Individual Studiesmentioning

confidence: 99%

“…As with studies related to other endpoints, we identified several methodological flaws in the studies by Chance et al [47] and Dincic et al [43] which lowered the confidence in the reported results.…”

Section: Cardiovascular Parametersmentioning

confidence: 90%

“…However, it remained unclear from the interpretation of the results what significance they might have for health. Dincic and colleagues reported increases in enzyme activities (ATPase and acetylcholinesterase) and oxidative stress markers (malondialdehyde) in the brain of rats upon long-term exposure to differently oriented SMF of 1 mT [43]. While the authors concluded from their results that exposure to SMF might be a promising tool in the treatment of neuronal diseases, a possible mechanism for the observed alterations could not be proposed.…”

Section: Cardiovascular Parametersmentioning

confidence: 98%

“…Five studies adequately addressed all three key risk-of-bias criteria. In the remaining six studies, methodological flaws were mainly identified regarding two key criteria: Five studies lacked information on procedures to ensure Identical experimental conditions across study groups [40][41][42][43][44] and Confidence in the outcome assessment was lowered in three studies [40][41][42] due to, e.g., the use of potentially insensitive instruments. Confidence in the exposure PLOS ONE https://doi.org/10.1371/journal.pone.0230038.g001…”

Section: Study Appraisalmentioning

confidence: 99%

“…Studies in three different laboratories investigated effects of exposure to SMF on the brain and nervous system. One study focused on effects of exposure on working memory abilities and brain activity [39]; the remaining two studies examined the influence of SMF on the levels of neurotransmitters [47] and on enzyme activities and oxidative stress in brain synaptosomes [43]. The experiments were done in mice and rats.…”

Section: Cardiovascular Parametersmentioning

confidence: 99%

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Biological and health-related effects of weak static magnetic fields (≤ 1 mT) in humans and vertebrates: A systematic review

et al. 2020

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Background There is a rapid development in technologies that generate weak static magnetic fields (SMF) including high-voltage direct current (HVDC) lines, systems operating with batteries, such as electric cars, and devices using permanent magnets. However, few reviews on the effects of such fields on biological systems have been prepared and none of these evaluations have had a particular focus on weak SMF (� 1 mT). The aim of this review was to systematically analyze and evaluate possible effects of weak SMF (� 1 mT) on biological functioning and to provide an update on the current state of research. Methods This review was prepared in accordance with the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) statement. Methodological limitations in individual studies were assessed using the Office of Health Assessment and Translation (OHAT) Risk-of-Bias Rating Tool. Results Eleven studies fulfilled the eligibility criteria and were included in this review. All included studies were experimental animal studies as no human studies were among the eligible articles. Eight of the eleven studies reported responses of rat, rabbits and quails to weak SMF exposure that were expressed as altered melatonin biosynthesis, reduced locomotor activity, altered vasomotion and blood pressure, transient changes in blood pressure-related biochemical parameters, or in the level of neurotransmitters and increases in enzyme activities. It remained largely unclear from the interpretation of the results whether the reported effects in the evaluated studies were beneficial or detrimental for health. Conclusion The available evidence from the literature reviewed is not sufficient to draw a conclusion for biological and health-related effects of exposure to weak SMF. There was a lack of

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