Impact of SMFs on Microorganisms, Plants, and Animals

Yang, Baolin; Cheng, Lei; Liu, Zicheng; Zhao, Yanan; Xu, An

doi:10.1007/978-981-19-8869-1_7

Cited by 4 publications

(4 citation statements)

References 275 publications

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“…It has been reported that low to medium intensities of SMFs do not have a significant effect on cells. However, in the presence of external factors, they can lead to the generation of free radicals thereby making their effects notably pronounced 29 , 30 . The co-treatment of cells with SMF and compounds such as Fecl3 has exhibited higher levels of lipid peroxidation and oxidative damage to DNA, all of which point to the synergistic effects of SMF on free radicals 15 , 23 .…”

Section: Discussionmentioning

confidence: 99%

Static magnetic field reduces cisplatin resistance via increasing apoptosis pathways and genotoxicity in cancer cell lines

Zafari,

Rastegar-Pouyani,

Javani Jouni

et al. 2024

Sci Rep

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Cisplatin is a chemotherapy drug widely used in cancer treatment. Alongside its clinical benefits, however, it may inflict intolerable toxicity and other adverse effects on healthy tissues. Due to the limitation of administering a high dose of cisplatin as well as cancer drug resistance, it is necessary to utilize new methods optimizing treatment modalities through both higher therapeutic efficacy and reduced administered doses of radiation and drugs. In this study, sensitive (A2780) and resistant (A2780CP) ovarian carcinoma cells underwent treatment with cisplatin + static magnetic field (SMF). First, the levels of genotoxicity after treatment were evaluated by Comet assay. Then, cell cycle analysis and apoptosis assay were conducted by a flow cytometer. Lastly, the expression levels of genes involved in apoptosis and cellular drug uptake were investigated by PCR. After treating different groups of cells for 24, 48, and 96 h, the co-treatment of SMF and cisplatin as a combination managed to increase the amount of DNA damage in both sensitive and resistant cell lines. A considerable increase in mortality of cells was also observed mostly in the form of apoptosis, which was caused by inhibition of the cell cycle. The combination also increased the expression levels of apoptotic genes, namely P53 and P21; however, it did not have much effect on the expression levels of BCL2. Besides, the levels of CTR1 gene expression increased significantly in the groups receiving the aforementioned combination. Our study suggests that the combination of cisplatin + SMF might have clinical potential which needs further investigations through future studies.

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Section: Discussionmentioning

confidence: 99%

Static magnetic field reduces cisplatin resistance via increasing apoptosis pathways and genotoxicity in cancer cell lines

Zafari,

Rastegar-Pouyani,

Javani Jouni

et al. 2024

Sci Rep

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“…In the last few decades, SMF has been widely applied in medicine, such as magnetic resonance imaging (MRI), which is one of the most common clinical diagnostic equipment due to its powerful imaging capability. Higher magnetic field intensity of MRI has been pursued to increase the resolution and sensitivity while reducing exposure time 1 . In most hospitals, MRI strength ranges from 1.5 to 3.0 T, which has been proven to be nonhazardous 2 .…”

Section: Introductionmentioning

confidence: 99%

“…Higher magnetic field intensity of MRI has been pursued to increase the resolution and sensitivity while reducing exposure time. 1 In most hospitals, MRI strength ranges from 1.5 to 3.0 T, which has been proven to be nonhazardous. 2 The strongest human MRI scanner of 10.5 T has been tested, and a 21.1 T small‐bore MRI has also been used on rodents.…”

Section: Introductionmentioning

confidence: 99%

Ultra‐high static magnetic fields cause immunosuppression through disrupting B‐cell peripheral differentiation and negatively regulating BCR signaling

Gu,

Fu,

et al. 2023

MedComm

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To increase the imaging resolution and detection capability, the field strength of static magnetic fields (SMFs) in magnetic resonance imaging (MRI) has significantly increased in the past few decades. However, research on the side effects of high magnetic field is still very inadequate and the effects of SMF above 1 T (Tesla) on B cells have never been reported. Here, we show that 33.0 T ultra‐high SMF exposure causes immunosuppression and disrupts B cell differentiation and signaling. 33.0 T SMF treatment resulted in disturbance of B cell peripheral differentiation and antibody secretion and reduced the expression of IgM on B cell membrane, and these might be intensity dependent. In addition, mice exposed to 33.0 T SMF showed inhibition on early activation of B cells, including B cell spreading, B cell receptor clustering and signalosome recruitment, and depression of both positive and negative molecules in the proximal BCR signaling, as well as impaired actin reorganization. Sequencing and gene enrichment analysis showed that SMF stimulation also affects splenic B cells' transcriptome and metabolic pathways. Therefore, in the clinical application of MRI, we should consider the influence of SMF on the immune system and choose the optimal intensity for treatment.

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“…Based on previous studies, the effect of a 30 mT magnetic field on biological systems has been studied in the past on plant and animal cells [4]. The intensity of 30 mT magnetic fields has been introduced as the lowest threshold intensity for displacing magnetic materials in living organisms [5].…”

Section: Introductionmentioning

confidence: 99%

Investigating the Effect of Static Magnetic Field and Magnetic Iron Oxide Nanoparticle on Enzymatic Antioxidant Defense in Dracocephalum polychaetum Cell Suspension Culture

Taghizadeh,

Nasibi,

Oloumi

2023

Glob. J. Agric. Innov. Res. Dev

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This study was conducted to investigate the effect of magnetic iron oxide nanoparticles (MNP) and static magnetic field (SMF) on the activity of antioxidant enzymes in the cell suspension culture of Dracocephalum polychaetum (Lamiaceae family). The treatment procedure was done by cultivating the cells either with 100 ppm MNP, SMFs, or simultaneous exposure to both MNP and SMFs. The SMF at 30 mT was uniformly applied to the cells either for 3 or 4 days with 3 hours per day or 5 hours per day intervals, respectively. The highest activity of polyphenol oxidase (PPO), phenylalanine ammonia-lyase (PAL), catalase (CAT), malondialdehyde (MDA) content, and electrical conductivity (EC) were observed under the elicitation of the cells with simultaneous exposure to both MNP and SMFs, but the highest amount of FRAP value was observed under the elicitation of the sample with the MNP treatment. Also, the results of this study showed that the greatest activity of peroxidase (POX) was observed under SMF and MNP treatments. In general, SMF and MNP treatments caused various changes in cell structure and metabolism by inducing oxidative stress and having a direct effect on the membrane. The cell activated its enzymatic antioxidant defense system in response to these treatments, which caused changes in its activity and amount compared to the control cell.

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Impact of SMFs on Microorganisms, Plants, and Animals

Cited by 4 publications

References 275 publications

Static magnetic field reduces cisplatin resistance via increasing apoptosis pathways and genotoxicity in cancer cell lines

Static magnetic field reduces cisplatin resistance via increasing apoptosis pathways and genotoxicity in cancer cell lines

Ultra‐high static magnetic fields cause immunosuppression through disrupting B‐cell peripheral differentiation and negatively regulating BCR signaling

Investigating the Effect of Static Magnetic Field and Magnetic Iron Oxide Nanoparticle on Enzymatic Antioxidant Defense in Dracocephalum polychaetum Cell Suspension Culture

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