Modulation of rat gastric mucosal prostaglandin E2 release by dietary linoleic acid: Effects on gastric acid secretion and stress-induced mucosal damage

Schepp, Wolfgang; Steffen, B.; Ruoff, H. J.; Schusdziarra, V.; Classen, Meinhard

doi:10.1016/0016-5085(88)90285-5

Cited by 42 publications

(20 citation statements)

References 12 publications

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“…The influence of specific n-6 fatty acids, such as linoleic acid (18:2n-6) and arachidonic acid (20:4n-6), on gastric mucosal resistance to injury in rats has been studied extensively (5)(6)(7)(8). Dietary deficiency of linoleic acid was shown to predispose rats to increased gastric mucosal injury, whereas chronic dietary supplementation with linoleic acid increased the concentration of prostaglandin E 2 (PGE-2 ) in the gastric lumen and decreased cold restraint injury.…”

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confidence: 99%

Dietary cod liver oil decreases arachidonic acid in rat gastric mucosa and increases stress‐induced gastric erosions

Ólafsson¹,

Hallgrímsson²,

Gudbjarnason³

2000

Lipids

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The purpose of this study was to examine the influence of long-term feeding of dietary fat rich in either n-3 or n-6 fatty acids on the availability of arachidonic acid (20:4n-6) in major phospholipids of gastric mucosa in rats. Three groups of male Wistar rats were fed either a standard diet, a cod liver oil-enriched diet (10% by weight), or a corn oil-enriched diet (10% by weight) for 8 mon. Dietary cod liver oil significantly reduced the level of 20:4n-6 in phosphatidylcholine (PC) and in phosphatidylethanolamine (PE) of gastric mucosa. The loss of 20:4n-6 was compensated for by eicosapentaenoic acid (20:5n-3) in PC, whereas the decrease in 20:4n-6 in PE corresponded to the increase in three n-3 fatty acids: 20:5n-3, docosapentaenoic acid (22:5n-3), and docosahexaenoic acid (22:6n-3). The level of 20:5n-3 was higher than the level of 22:6n-3 both in PC and PE of mucosa in rats fed cod liver oil. Diets supplemented with corn oil increased the level of 18:2n-6 but decreased the monoene fatty acids 16:1 and 18:1n-7 in PC but not in PE of gastric mucosa. The 20:4n-6 levels of both PC and PE were markedly reduced by dietary cod liver oil, to about one-third of control levels. Similar changes were also observed in the stomach wall. Gastric erosions were observed in all rats exposed to restriction stress, but this form of stress induced twice the number of erosions in rats fed fish oil compared to control rats or rats fed corn oil. We conclude that a diet rich in fish oil altered the balance between n-6 and n-3 fatty acids in major gastric mucosal phospholipids, markedly reduced the availability of 20:4n-6, and increased the incidence of gastric erosions induced by restriction or emotional stress.

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mentioning

confidence: 99%

Dietary cod liver oil decreases arachidonic acid in rat gastric mucosa and increases stress‐induced gastric erosions

Ólafsson¹,

Hallgrímsson²,

Gudbjarnason³

2000

Lipids

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“…Only certain seed oils contain essential fatty acids of the ω 6 series which are known to play a part in prostaglandin synthesis and have been shown to be protective in several rat models (Schepp et al, 1988). A low intake of linoleic acid has been associated with a high prevalence of duodenal ulcer (Grant et al, 1990).…”

Section: Discussionmentioning

confidence: 99%

“…Certain lipids, including essential fatty acids (Grant et al , 1988;Schepp et al , 1988;Tarnawski et al , 1986), phospholipids (Hills, 1996;Swarm et al , 1987;Lichtenberger et al , 1983Lichtenberger et al , , 1990) and sterols, can give protection against experimental peptic ulceration (Ghosal and Saini, 1984;Romero and Lichtenberger, 1990). Both the protective and also healing effect of the lipid extracts from horse gram in experimental peptic ulcer models has been reported (Jayaraj et al , 2000).…”

Section: Introductionmentioning

confidence: 88%

Duodenal ulcer prevalence: research into the nature of possible protective dietary lipids

Jayaraj

Tovey

Hobsley

2003

Phytotherapy Research

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The varying geographical prevalence of duodenal ulceration has suggested a relationship to staple diet. Previous experiments on animal peptic ulcer models showed that certain foods, particularly the lipid fraction, are ulceroprotective. This paper reports experiments on animal models further to investigate the nature of the protective substances in the most active lipid, that of horse gram. The free fatty acids and triglycerides, sterols, sterol esters and phospholipids from horse gram were extracted and tested for protective activity on rat peptic ulcer models: the pyloric ligation model which is chronic, involving 14 days pre-feeding, and two acute models using ethanol or cysteamine to induce ulceration. The results showed that sterol esters, but not sterols, were protective in the pyloric ligation model. Sterols were protective in the acute models using ethanol-induced and cysteamine-induced ulceration. Phospholipids were protective in both types of model. The free fatty acids and triglycerides gave no protection using the pyloric ligation model. The presence of sterols, sterol esters and phospholipids in the lipid fraction of foods in staple diets may account for the low prevalence of duodenal ulcer in certain geographical areas, despite a uniformly high prevalence of Helicobacter pylori infection.

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“…The organ cultures were carried out in tissue culture medium (RPMI 1640: Sigma Chemical Co, St Louis, MO, USA), buffered with 10 mmol I-' HEPES, pH 7.4, containing penicillin (100 U ml -I ) and streptomycin (100 pg ml ~ I). [5,6,8,9,11,12,14,15 -'HI-arachidonic acid ( I00 Ci mmol-I) and ['4C]-linoleic acid (50.5 mCi mmol-' ) were obtained from New England Nuclear (Du Ponte Nemours, Bad Homburg, FRG). The organic solvents 5 kBq)) was added.…”

Section: Methodsmentioning

confidence: 99%

Arachidonic acid absorption in human jejunum in organ culture: effects of ethanol

Barros

CHEN

Florén

et al. 1990

Eur J Clin Investigation

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Abstract. Human jejunal tissue obtained by peroral biopsy was cultured in control medium and in medium containing 100 mmol I-' ethanol. Subsequently, the incorporation and metabolism of [3H]-arachidonic and [14C]-linoleic acid were evaluated. Of the two fatty acids a significantly higher amount of ['HI-arachidonic acid was incorporated into phospholipids and more [14C]-linoleic acid was incorporated into triacylglycer01s. This preferential distribution of the labelled fatty acids was not affected by ethanol, but when ethanol was present in the tissue culture medium, there was a significant decrease in the incorporation of both fatty acids into tissue phospholipids. The study thus shows that ethanol in moderate concentrations can affect human jejunal absorption and metabolism of polyenoic fatty acids, contributing to a decrease in the amount of eicosanoid precursors available in jejunal tissue.

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Modulation of rat gastric mucosal prostaglandin E2 release by dietary linoleic acid: Effects on gastric acid secretion and stress-induced mucosal damage

Cited by 42 publications

References 12 publications

Dietary cod liver oil decreases arachidonic acid in rat gastric mucosa and increases stress‐induced gastric erosions

Dietary cod liver oil decreases arachidonic acid in rat gastric mucosa and increases stress‐induced gastric erosions

Duodenal ulcer prevalence: research into the nature of possible protective dietary lipids

Arachidonic acid absorption in human jejunum in organ culture: effects of ethanol

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