Modulation of Presaccadic Activity in the Frontal Eye Field by the Superior Colliculus

Berman, Rebecca; Joiner, Wilsaan M.; Cavanaugh, James; Wurtz, Robert H.

doi:10.1152/jn.00053.2009

Cited by 31 publications

(23 citation statements)

References 43 publications

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“…Pharmacological inactivation of the SNpr in monkeys causes SWJ due to the disinhibition of saccade-related SC neurons 3 4. In PD, however, there is increased excitation of the SNpr 26 27. Therefore the insufficient nigro-collicular inhibition hypothesis for SWJ is unlikely.…”

Section: Discussionmentioning

confidence: 99%

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'Staircase' square-wave jerks in early Parkinson's disease

Shaikh

Xu-Wilson

Grill

et al. 2010

British Journal of Ophthalmology

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Loss of dopaminergic neurons in the substantia nigra pars compacta leading to phasic excitation of the substantia nigra pars reticulata and, in turn, phasic inhibition of the superior colliculus (SC), may account for 'staircase' visually guided saccades in these patients. This mechanism, however, does not explain abnormally large SWJ, which in the traditional view results from decreased inhibition upon SC. The abnormally large SWJ could be due to a compensatory increase in frontal eye field activity secondary to the increased inhibition upon the SC. Abnormally large and frequent SWJ are often used clinically to distinguish multi-system atrophy from idiopathic PD. Our study, however, suggests that idiopathic PD cannot be excluded if the patient has large-amplitude SWJ.

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Section: Discussionmentioning

confidence: 99%

“…Ascending pathways from the SC to FEF carry signals that reduce presaccadic activity in the FEF 25 26. Thus inactivation of the SC could lead to increased presaccadic activity in the FEF 27. A phasic increase in the presaccadic activity in FEF is therefore possible in PD, because of the associated phasic inhibition of SC (figure 4C).…”

Section: Discussionmentioning

confidence: 99%

'Staircase' square-wave jerks in early Parkinson's disease

Shaikh

Xu-Wilson

Grill

et al. 2010

British Journal of Ophthalmology

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“…Although the luminance specificity of saccadic suppression may yet be an important clue to its neural implementa- (Lyon et al 2010), whereas the FEF (red-orange lines) and LIP (yellow lines) are reciprocally connected with both ventral and dorsal visual cortex (Baizer et al 1991;Shipp and Zeki 1995;Stanton et al 1995;Ungerleider et al 2008;Anderson et al 2011). Extensive connectivity also exists between these oculomotor regions, including a corollary discharge pathway from the SC to FEF (Sommer and Wurtz 2000, 2006Ferraina et al 2002;Berman et al 2009). FEF, frontal eye field; LIP, lateral intraparietal area; SC, superior colliculus; PI, inferior pulvinar;…”

Section: Saccadic Suppression Of Neuronal Responses To Visual Stimulimentioning

confidence: 99%

The Influence of Gaze Control on Visual Perception: Eye Movements and Visual Stability

Krock

Moore

2014

Cold Spring Harb Symp Quant Biol

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Primates make several saccadic eye movements each second, and yet the retinal motion these movements generate goes unnoticed. Saccadic suppression is a profound loss of visual sensitivity occurring around the time of eye movements, and it is thought to contribute to visual stability by blunting the perception of self-generated motion. Neurophysiological studies have produced evidence that neurons throughout the visual system, including both the dorsal and ventral streams of extrastriate visual cortex, show a reduction in visual responses or sensitivity around the time of saccades. However, the source of this suppression remains unknown. We review evidence that oculomotor regions such as the superior colliculus and frontal eye field may play a role, as well as anatomical data that place constraints on possible mechanisms of suppression.

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“…%pop., percent of population; p indicates p value in Wilcoxon Signed Rank test.compensatory effect exists elsewhere in the oculomotor system:1135 SC inactivation, which partially impairs saccades, sometimes 1136 produces an increase in presaccadic FEF activity(Berman et al, 1137(Berman et al, 2009). Another possibility is that the increase in response 1138 magnitude results from a release of lateral inhibition within V4.…”

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confidence: 99%

Visual attention: Linking prefrontal sources to neuronal and behavioral correlates

Clark

Squire

Merrikhi

et al. 2015

Progress in Neurobiology

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Attention is a means of flexibly selecting and enhancing a subset of sensory input based on the current behavioral goals. Numerous signatures of attention have been identified throughout the brain, and now experimenters are seeking to determine which of these signatures are causally related to the behavioral benefits of attention, and the source of these modulations within the brain. Here, we review the neural signatures of attention throughout the brain, their theoretical benefits for visual processing, and their experimental correlations with behavioral performance. We discuss the importance of measuring cue benefits as a way to distinguish between impairments on an attention task, which may instead be visual or motor impairments, and true attentional deficits. We examine evidence for various areas proposed as sources of attentional modulation within the brain, with a focus on the prefrontal cortex. Lastly, we look at studies that aim to link sources of attention to its neuronal signatures elsewhere in the brain.

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Modulation of Presaccadic Activity in the Frontal Eye Field by the Superior Colliculus

Abstract: Berman RA, Joiner WM, Cavanaugh J, Wurtz RH. Modulation of presaccadic activity in the frontal eye field by the superior colliculus.

Cited by 31 publications

References 43 publications

'Staircase' square-wave jerks in early Parkinson's disease

'Staircase' square-wave jerks in early Parkinson's disease

The Influence of Gaze Control on Visual Perception: Eye Movements and Visual Stability

Visual attention: Linking prefrontal sources to neuronal and behavioral correlates

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