Modulation of PAF production by incorporation of arachidonic acid and eicosapentaenoic acid in phospholipids of human leukemic monocyte-like cells THP-1

Martin-Chouly, Corinne; Menier, Véronique; Hichami, Aziz; Youmine, H.; Noël, Françoise; Pédrono, Frédérique; Legrand, Alain

doi:10.1016/s0090-6980(99)00058-1

Cited by 9 publications

(3 citation statements)

References 21 publications

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“…The endocannabinoids can bind to cannabinoid receptor types 1 and 2, which have anti-inflammatory properties (Artmann et al, 2008;Batetta et al, 2009;Wood et al, 2010). Other studies have shown that through incorporation in the cell membrane, n-3 LC-PUFA reduce the production of platelet-activating factor in certain immune cells (Croft et al, 1986;Pickett et al, 1986;Sperling et al, 1987;Shikano et al, 1993;Martin-Chouly et al, 2000;Watanabe et al, 2001). Finally, incorporation of EPA and DHA disrupts the formation of lipid rafts in the membrane, which can lead to changes in cell signal transduction during inflammation (Reviewed by Pike, 2003).…”

Section: Production Of Lipid Mediators That Resolve Inflammationmentioning

confidence: 99%

Possible Health Effects of a Wax Ester Rich Marine Oil

et al. 2020

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The consumption of seafood and the use of fish oil for the production of nutraceuticals and fish feed have increased over the past decades due the high content of long-chain polyunsaturated omega-3 fatty acids. This increase has put pressure on the sustainability of fisheries. One way to overcome the limited supply of fish oil is to harvest lower in the marine food web. Calanus finmarchicus, feeding on phytoplankton, is a small copepod constituting a considerable biomass in the North Atlantic and is a novel source of omega-3 fatty acids. The oil is, however, different from other commercial marine oils in terms of chemistry and, possibly, bioactivity since it contains wax esters. Wax esters are fatty acids that are esterified with alcohols. In addition to the long-chain polyunsaturated omega-3 fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), the oil is also rich in stearidonic acid (SDA), long-chain monounsaturated fatty acids, and the long-chain fatty alcohols eicosenol and docosenol. Recent animal studies have indicated antiinflammatory and anti-obesogenic actions of this copepod oil beyond that provided by EPA and DHA. This review will discuss potential mechanisms behind these beneficial effects of the oil, focusing on the impact of the various components of the oil. The health effects of EPA and DHA are well recognized, whereas long-chain monounsaturated fatty acids and long-chain fatty alcohols have to a large degree been overlooked in relation to human health. Recently, however the fatty alcohols have received interest as potential targets for improved health via conversion to their corresponding fatty acids. Together, the different lipid components of the oil from C. finmarchicus may have potential as nutraceuticals for reducing obesity and obesity-related metabolic disorders.

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Section: Production Of Lipid Mediators That Resolve Inflammationmentioning

confidence: 99%

Possible Health Effects of a Wax Ester Rich Marine Oil

et al. 2020

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“…Feeding cells or animals with n-3 PUFA results in replacement of n-6 with n-3 fatty acid at the sn-2 position [145,236]. n-3 fatty acyl chains (EPA or DHA) in the sn-2 position are poor substrates for cytosolic phospholipase A 2 (cPLA 2 ) [146,147], therefore incorporation of n-3 PUFA may reduce the availability of free AA and consequently n-6 series eicosanoids. In addition, 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine (PC) can be converted to 1-O-alkyl-2-lyso-PC and then to the platelet activating factor (PAF), 1-O-alkyl-2-acetyl-(PC).…”

Section: Mechanism Of Action Of Pufas In Cancer Cellsmentioning

confidence: 99%

Dietary fat’gene interactions in cancer

Chen

Edwards

Kridel

et al. 2007

Cancer Metastasis Rev

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Epidemiologic studies have suggested for decades an association between dietary fat and cancer risk. A large body of work performed in tissue culture and xenograft models of cancer supports an important role of various types of fat in modulating the cancer phenotype. Yet, the molecular mechanisms underlining the effects of fat on cancer initiation and progression are largely unknown. The relationships between saturated fat, polyunsaturated fat, cholesterol or phytanic acid with cancer have been reviewed respectively. However, few have considered the relationship between all of these fats and cancer. The purpose of this review is to present a more cohesive view of dietary fat-gene interactions, and outline a working hypothesis of the intricate connection between fat, genes and cancer.

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“…sPLA2 and cPLA2 can selectively release AA from the sn -2 position of phospholipids and the released AA is then the substrate of oxygenases. Interestingly, phospholipids with ω3 PUFA (EPA or DHA) in the sn -2 position are poor substrates for cPLA2 [84, 85]. In contrast, iPLA2 may selectively release DHA [86].…”

Section: Pufa Oxidation and Cyclingmentioning

confidence: 99%

Polyunsaturated fatty acid metabolism in prostate cancer

Berquin

Edwards

Kridel

et al. 2011

Cancer Metastasis Rev

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Polyunsaturated fatty acids (PUFA) play important roles in the normal physiology and in pathological states including inflammation and cancer. While much is known about the biosynthesis and biological activities of eicosanoids derived from ω6 PUFA, our understanding of the corresponding ω3 series lipid mediators is still rudimentary. The purpose of this review is not to offer a comprehensive summary of the literature on fatty acids in prostate cancer but rather to highlight some of the areas where key questions remain to be addressed. These include substrate preference and polymorphic variants of enzymes involved in the metabolism of PUFA, the relationship between de novo lipid synthesis and dietary lipid metabolism pathways, the contribution of cyclooxygenases and lipoxygenases as well as terminal synthases and prostanoid receptors in prostate cancer, and the potential role of PUFA in angiogenesis and cell surface receptor signaling.

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Modulation of PAF production by incorporation of arachidonic acid and eicosapentaenoic acid in phospholipids of human leukemic monocyte-like cells THP-1

Cited by 9 publications

References 21 publications

Possible Health Effects of a Wax Ester Rich Marine Oil

Possible Health Effects of a Wax Ester Rich Marine Oil

Dietary fat’gene interactions in cancer

Polyunsaturated fatty acid metabolism in prostate cancer

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