Dietary fat’gene interactions in cancer

Chen, Yong Q.; Edwards, Iris J.; Kridel, Steven J.; Thornburg, Todd; Berquin, Isabelle M.

doi:10.1007/s10555-007-9075-x

Cited by 59 publications

(54 citation statements)

References 206 publications

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“…However, the hydrolysis of the fish was characterized by an initial rapid phase, during which a large number of peptide bonds were hydrolyzed. The protease activity red sea bream Pagrus major [32] and Takifugu obscurus [33] also initiate hydrolysis of the intact protein as it was observed in the present study.…”

Section: Protease Activitysupporting

confidence: 85%

Bioactive and Functional Properties of Fish Protein Hydrolysate From Leiognathus Bindus

Johnrose¹,

Vincent²,

Joseph³

et al. 2016

Asian J Pharm Clin Res

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Objective: The present work is focused on the production of biologically active protein hydrolysate from low value by-catch fish, Leiognathus bindus; this will be an ideal approach to exploit the underutilized fish to develop a highly nutritious bioactive product. Moreover, fish protein hydrolysates have a broad spectrum of applications ranging from high-value peptones to food ingredients with special functional properties. Methods:The protein hydrolysate was prepared from L. bindus through acidic autolysis processes. The proximate composition, physico-functional, and biochemical properties of hydrolysate and control samples were characterized by standard protocols. Molecular profiling was done by sodium dodecyl sulfate polyacrylamide gel electrophoresis and high-performance liquid chromatography analysis performed to identify the essential amino acid composition in protein hydrolysate. Results:The results of this study reveals that the protein hydrolysate obtained from the trash fish has relatively high protein (71.01±0.2%) and low lipid (1.57±0.1%) content. The molecular analysis shows low molecular weight peptides are obtained in the hydrolyzed samples which indicate high protein solubility confirmed to have the potential application as an ingredient in the balanced human diet. The chemical score of the hydrolysate indicates that it fulfills adult human nutritional requirements. Conclusion:This approach also offers the relatively simple and cost-effective process to improve the nutritional characteristics and functional properties of foodstuff, also an opportunity for the conversion of waste fish resources to nutritious products, that can be used in food and pharmaceutical industries.

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Section: Protease Activitysupporting

confidence: 85%

Bioactive and Functional Properties of Fish Protein Hydrolysate From Leiognathus Bindus

Johnrose¹,

Vincent²,

Joseph³

et al. 2016

Asian J Pharm Clin Res

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“…Treatment of aggressive metastatic breast cancer cell lines with DHA and EPA decreased transcription of polycomb group (PcG) protein, enhancer of zeste homologue 2 (EZH2) (Dimri et al,), a protein that is over expressed in metastatic cells. Conversely, treatment with linoleic acid and arachidonic acid, two n-6 PUFAs, had no effect on EZH2 expression, confirming previous reports that suggest the beneficial effects of fatty acids on metastasis are specific for n-3 PUFAs, while n-6 PUFAs are associated with increased risk of metastasis (Bartsch et al, 1999;Chen et al, 2007;Hubbard & Erickson, 1987). DHA and EPA were also shown to inhibit expression of MMP-2 and MMP-9 (Suzuki et al, 1997).…”

Section: Fish Oilsupporting

confidence: 80%

The Beneficial Effects of Nutritional Compounds on Breast Cancer Metastasis

Altenburg¹,

Siddiqui²

2011

Breast Cancer - Current and Alternative Therapeutic Modalities

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“…In addition, saturated fat intake has been linked to an increased risk of disease progression and death in men with prostate cancer (16,17). There are several potential mechanisms by which saturated fat intake might influence disease progression, including its influence on circulating sex steroid hormones (32) and providing an advantage for tumor cell survival and proliferation (33).…”

Section: Effect Of the Lifestyle Interventionmentioning

confidence: 99%

Lifestyle Intervention in Men with Advanced Prostate Cancer Receiving Androgen Suppression Therapy: A Feasibility Study

Bourke

Doll

Crank

et al. 2011

Cancer Epidemiology, Biomarkers &Amp; Prevention

145

260

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Background: Healthy lifestyle behaviors could have a role in ameliorating some of the adverse effects of androgen suppression therapy (AST) in men with prostate cancer. The primary aim of this study was to assess the feasibility of a tapered supervised exercise program in combination with dietary advice in men with advanced prostate cancer receiving AST.Methods: Advanced prostate cancer patients receiving AST for a minimum of 6 months were randomized to a 12-week lifestyle program comprising aerobic and resistance exercise, plus dietary advice (n ¼ 25), or standard care (n ¼ 25). Exercise behavior, dietary macronutrient intake, quality of life, fatigue, functional fitness, and biomarkers associated with disease progression were assessed at baseline, after the intervention, and at 6 months.Results: The lifestyle group showed improvements in exercise behavior (P < 0.001), dietary fat intake (P ¼ 0.001), total energy intake (P ¼ 0.005), fatigue (P ¼ 0.002), aerobic exercise tolerance (P < 0.001), and muscle strength (P ¼ 0.033) compared with standard care controls. Although a high rate of attrition (44%) was observed at 6 months, the improvements in key health outcomes were sustained. No effects on clinical prostate cancer disease markers were observed.Conclusions: This preliminary evidence suggests that pragmatic lifestyle interventions have potential to evoke improvements in exercise and dietary behavior, in addition to other important health outcomes in men with advanced prostate cancer receiving AST.Impact: This study shows for the first time that pragmatic lifestyle interventions are feasible and could have a positive impact on health behaviors and other key outcomes in men with advanced prostate cancer receiving AST. Cancer Epidemiol Biomarkers Prev; 20(4); 647-57. Ó2011 AACR.

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Dietary fat’gene interactions in cancer

Cited by 59 publications

References 206 publications

Bioactive and Functional Properties of Fish Protein Hydrolysate From Leiognathus Bindus

Bioactive and Functional Properties of Fish Protein Hydrolysate From Leiognathus Bindus

The Beneficial Effects of Nutritional Compounds on Breast Cancer Metastasis

Lifestyle Intervention in Men with Advanced Prostate Cancer Receiving Androgen Suppression Therapy: A Feasibility Study

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