Modulation of long-term and short-term plasticity in the dentate gyrus granule cells by activating the β-adrenergic receptors of the basolateral amygdala

Noorani, Seyedeh Kebria; Hojati, Vida; Ardeshiri, Motahareh Rouhi; Akbari, Esmaeil; Ehsani, Simin

doi:10.1016/j.neulet.2020.134878

Cited by 6 publications

(5 citation statements)

References 23 publications

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“…Activation of the beta-adrenergic receptors of the BLA can improve the long-term potentiation induction in the dentate gyrus (DG) that is important for memory formation. 33 We found enhanced connectivity between the amygdala and the DG, indicating negative memory formation after IMQ treatment.…”

Section: Discussionmentioning

confidence: 66%

“…In IMQ‐treated mice, we also observed enhanced connectivity between the piriform cortex and amygdala, indicating its special role in anxiety modulation. Activation of the beta‐adrenergic receptors of the BLA can improve the long‐term potentiation induction in the dentate gyrus (DG) that is important for memory formation 33 . We found enhanced connectivity between the amygdala and the DG, indicating negative memory formation after IMQ treatment.…”

Section: Discussionmentioning

confidence: 76%

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Resting‐state fMRI reveals changes within the anxiety and social avoidance circuitry of the brain in mice with psoriasis‐like skin lesions

Chen,

Zhu,

et al. 2023

Experimental Dermatology

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Psoriasis is an autoimmune skin disease that often co‐occurs with psychological morbidities such as anxiety and depression, and psychosocial issues also lead psoriasis patients to avoid other people. However, the precise mechanism underlying the comorbidity of psoriasis and anxiety is unknown. Also, whether the social avoidance phenomenon seen in human patients also exists in psoriasis‐like animal models remains unknown. In the present study, anxiety‐like behaviours and social avoidance‐like behaviours were observed in an imiquimod‐induced psoriasis‐like C57‐BL6 mouse model along with typical psoriasis‐like dermatitis and itch‐like behaviours. The 11.7T resting‐state functional magnetic resonance imaging showed differences in brain regions between the model and control group, and voxel‐based morphometry showed that the grey matter volume changed in the basal forebrain region, anterior commissure intrabulbar and striatum in the psoriasis‐like mice. Seed‐based resting state functional connectivity analysis revealed connectivity changes in the amygdala, periaqueductal gray, raphe nuclei and lateral septum. We conclude that the imiquimod‐induced psoriasis‐like C57‐BL6 mouse model is well suited for mechanistic studies and for performing preclinical therapeutic trials for treating anxiety and pathological social avoidance in psoriasis patients.

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Section: Discussionmentioning

confidence: 66%

Section: Discussionmentioning

confidence: 76%

Resting‐state fMRI reveals changes within the anxiety and social avoidance circuitry of the brain in mice with psoriasis‐like skin lesions

Chen,

Zhu,

et al. 2023

Experimental Dermatology

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“…Another fundamental synaptic function is synaptic plasticity, [ 73 ] which can be categorized either as short‐ or long‐term plasticity (STP and LTP, respectively). [ 74 , 75 ] STP and LTP can be considered as the major instruments of learning and memorization processes. A typical characteristic of synaptic plasticity is the so‐called paired‐pulse response, as shown in Figure 2d.2 .…”

Section: Working Mechanism and Unique Featuresmentioning

confidence: 99%

Advanced Neuromorphic Applications Enabled by Synaptic Ion‐Gating Vertical Transistors

Merces,

Ferro,

Nawaz

et al. 2024

Advanced Science

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Bioinspired synaptic devices have shown great potential in artificial intelligence and neuromorphic electronics. Low energy consumption, multi‐modal sensing and recording, and multifunctional integration are critical aspects limiting their applications. Recently, a new synaptic device architecture, the ion‐gating vertical transistor (IGVT), has been successfully realized and timely applied to perform brain‐like perception, such as artificial vision, touch, taste, and hearing. In this short time, IGVTs have already achieved faster data processing speeds and more promising memory capabilities than many conventional neuromorphic devices, even while operating at lower voltages and consuming less power. This work focuses on the cutting‐edge progress of IGVT technology, from outstanding fabrication strategies to the design and realization of low‐voltage multi‐sensing IGVTs for artificial‐synapse applications. The fundamental concepts of artificial synaptic IGVTs, such as signal processing, transduction, plasticity, and multi‐stimulus perception are discussed comprehensively. The contribution draws special attention to the development and optimization of multi‐modal flexible sensor technologies and presents a roadmap for future high‐end theoretical and experimental advancements in neuromorphic research that are mostly achievable by the synaptic IGVTs.

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“…141 Synaptic plasticity can be classified into short-term plasticity and longterm plasticity. 142,143 These are the primary working mechanisms of information processing, learning, and memorization. PPF and paired-pulse depression (PPD) are two common processes in STP.…”

Section: Biological System and Its Emulation Propertiesmentioning

confidence: 99%

Neural-inspired artificial synapses based on low-voltage operated organic electrochemical transistors

et al. 2023

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Modulation of long-term and short-term plasticity in the dentate gyrus granule cells by activating the β-adrenergic receptors of the basolateral amygdala

Cited by 6 publications

References 23 publications

Resting‐state fMRI reveals changes within the anxiety and social avoidance circuitry of the brain in mice with psoriasis‐like skin lesions

Resting‐state fMRI reveals changes within the anxiety and social avoidance circuitry of the brain in mice with psoriasis‐like skin lesions

Advanced Neuromorphic Applications Enabled by Synaptic Ion‐Gating Vertical Transistors

Neural-inspired artificial synapses based on low-voltage operated organic electrochemical transistors

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