Modulation of insulin resistance in ovariectomized rats by endurance exercise training and estrogen replacement

Saengsirisuwan, Vitoon; Pongseeda, Somrudee; Prasannarong, Mujalin; Vichaiwong, Kanokwan; Toskulkao, Chaivat

doi:10.1016/j.metabol.2008.08.004

Cited by 116 publications

(126 citation statements)

References 60 publications

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“…Decreases in female hormone secretion increase insulin resistance (4,5). OVX mice showed significantly increased weight gain, adipose tissue mass, and serum glucose levels, as compared to sham-operated mice, as described previously (9,14,15).…”

Section: Discussionsupporting

confidence: 74%

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Anti-Hyperglycemic Effect of a Kudzu (<i>Pueraria lobata</i>) Vine Extract in Ovariectomized Mice

Tanaka

Yukihiro

Tang

et al. 2016

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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Summary Postmenopausal diabetes is exacerbated by estrogen deficiency. Ovariectomized (OVX) animal models can be used to develop strategies for preventing or treating postmenopausal symptoms. We previously found that a diet containing kudzu (Pueraria lobata) vine ethanol extract (PVEE) suppressed weight gain in OVX mice. Therefore, this study further elucidated how PVEE affected OVX mice. Ten-week-old OVX or sham-operated mice were fed diets containing either no PVEE (control) ·d 21 puerarin (daidzein-8-C-glucoside), a major isoflavone present in PVEE, for 10 wk. The effects of puerarin on glucose tolerance were also tested in OVX mice. The experimental diets were not associated with any abnormalities in any mice tested in the present study. Weight gain and serum glucose levels were increased in OVX mice and these effects were significantly attenuated in OVX mice that consumed PVEE (5 or 20 mg·kg 21 ·d 21 ) or puerarin. Puerarin-treated OVX mice also showed reduced serum glucose levels following administration of 1,000 mg·kg 21 glucose. These results suggested that puerarin contributed to PVEE-mediated improvements in glucose metabolism in OVX mice. Although further studies are needed to clarify the molecular mechanism underlying these observations, PVEE and puerarin could provide effective approaches to the amelioration of postmenopausal diabetes. Key Words Kudzu, Pueraria lobata, postmenopausal diabetes, puerarin, glucose metabolism Postmenopausal women have an increased risk for metabolic diseases such as obesity and diabetes (1, 2), which increase their risk of developing other serious conditions including cancers, neurological disorders, hypertension, and other kinds of cardiovascular disease (3). Postmenopausal diabetes is induced by estrogen deficiency, which exacerbates insulin resistance (4, 5). The number of postmenopausal patients with diabetes has recently increased, due to the increasing age of the population. Therefore, dietary strategies to reduce the risk for diabetes are expected to be necessary in order to improve postmenopausal health.Kudzu (Pueraria lobata) is a creeping vine of the Leguminosae family. The plant has spread worldwide and is predominantly found in temperate climates. Dried kudzu roots (Puerariae radix) are traditionally used in Asian countries, including Japan, as an herbal medicine to treat the common cold, headaches, diarrhea, and hypertension. Prasain et al. demonstrated that kudzu root extract ameliorated impaired glucose and lipid metabolism in obese male mice (6). They also reported that in addition to lowering arterial blood pressure, a kudzu root extract diet significantly reduced blood cholesterol, glucose, and insulin levels in stroke-prone spontaneously hypertensive rats (7).Pharmaceutical legislation in Japan classifies the kudzu root as a medicinal resource, rather than a food, and we therefore investigated whether dietary consumption of other parts of the plant had beneficial effects on postmenopausal diabetes. Our previous study of a kudzu vine ethanol extract ...

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Section: Discussionsupporting

confidence: 74%

“…Postmenopausal diabetes is induced by estrogen deficiency, which exacerbates insulin resistance (4,5). The number of postmenopausal patients with diabetes has recently increased, due to the increasing age of the population.…”

mentioning

confidence: 99%

Anti-Hyperglycemic Effect of a Kudzu (<i>Pueraria lobata</i>) Vine Extract in Ovariectomized Mice

Tanaka

Yukihiro

Tang

et al. 2016

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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show abstract

“…In addition to insulin, estrogen also affects glucose tolerance and insulin resistance and might be associated with the development of diabetes mellitus (Riant et al, 2009;Saengsirisuwan et al, 2009). Nevertheless, an experimental study with estrogen replacement therapy, Ceylan-Isik et al (2009) found no positive effects on glycemic control.…”

Section: Discussionmentioning

confidence: 99%

Estrogen and Insulin Replacement Therapy Modulates the Expression of Insulin‐Like Growth Factor‐I Receptors in the Salivary Glands of Diabetic Mice

Yashida

Faria

Caldeira

2011

The Anatomical Record

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Diabetes mellitus results in various complications, also compromising the salivary glands. Hormone levels and interactions with cellular receptors are altered, intensifying the damage caused by this disease. Hormone replacement therapy alone or combined with other treatments may reverse this damage, but doubts still exist regarding the efficacy of this procedure. The objective of this study was to evaluate the effect of estrogen replacement therapy combined with insulin treatment on salivary secretory cells and on the expression of insulin-like growth factor (IGF)-I receptors in salivary glands of spontaneously diabetic (NOD) mice. Twenty-five mice were divided into five groups of five animals each: group I (NOD diabetic), group II (NOD diabetic treated with insulin), group III (NOD diabetic treated with estrogen), group IV (NOD diabetic treated with insulin and estrogen), and group V (control Balb/c mice). Group II received insulin, group III received estrogen, and group IV received insulin plus estrogen administered daily for 20 days. Groups I and V received saline for the same period of time to simulate treatment. Glucose and estrogen levels were monitored during treatment, and salivary gland samples were collected at the end of treatment for stereological analysis and immunofluorescence detection of IGF-I receptors. Tissue restructuring and regulation of IGF-I receptors expression were observed in animals submitted to estrogen replacement therapy plus insulin. Estrogen effectively promoted the recovery of salivary secretory cells, demonstrating that this hormone alone, and especially when combined with insulin, might be important for the reversal of hyperglycemia-induced tissue injury. Anat Rec, 294:1930Rec, 294: -1938Rec, 294: , 2011. V V C 2011 Wiley-Liss, Inc.

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“…While no statistically significant relationship between BSO and all-cause and cause-specific mortality was reported among participants in the third National Health and Nutritional Examination Survey obese women who underwent BSO before 40 years of age had an increased risk of mortality, with the lack of HT use compounding this effect. Studies in rodents reveal that BSO increases visceral fat content (250)(251)(252), LDL cholesterol, and produced a hyperinsulemic response to glucose tolerance implying insulin resistance which is partially reversed with estrogen supplementation (251,252). While no comparable data are available in humans, if estrogens decrease visceral fat accumulation in humans, then removal of the ovaries at an early age may have a more adverse effect on CVD risk than if this procedure is performed after the time of natural menopause when estrogen production is low (234,253).…”

Section: Fig 23 Actions Of Elevated Testosterone On Cardiovascular mentioning

confidence: 99%

“…Animal studies report that bilateral oophorectomy increases abdominal fat (250)(251)(252), which can be reversed with estrogen therapy (HT) (251,252). In the third National Health and Nutritional Examination Survey (311), obese women who underwent bilateral oophorectomy before 40 years of age had an increased risk of mortality, with the lack of HT use compounding this effect.…”

Section: Hypothesis Threementioning

confidence: 99%

Cardiovascular disease among diabetic women with bilateral oophorectomy.

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Modulation of insulin resistance in ovariectomized rats by endurance exercise training and estrogen replacement

Cited by 116 publications

References 60 publications

Anti-Hyperglycemic Effect of a Kudzu (<i>Pueraria lobata</i>) Vine Extract in Ovariectomized Mice

Anti-Hyperglycemic Effect of a Kudzu (<i>Pueraria lobata</i>) Vine Extract in Ovariectomized Mice

Estrogen and Insulin Replacement Therapy Modulates the Expression of Insulin‐Like Growth Factor‐I Receptors in the Salivary Glands of Diabetic Mice

Cardiovascular disease among diabetic women with bilateral oophorectomy.

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