Modulation of humoral immune responses by endogenous opioids

Mediratta, Pramod Kumari; Das, Nirupam; Gupta, Vasudha; Sen, P

doi:10.1016/0091-6749(88)90216-3

Cited by 18 publications

(8 citation statements)

References 13 publications

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“…This latter effect is supporting earlier findings, indicating that blockade of opioid receptors suppressed the formation of IgE [53,54]. Concerning cytokines, we observed a transient (α S1 ) or sustained (EKC) increase of IL-6 secretion from U266 cells and an inhibition of IL-8 and -10 secretion by RPMI 8226 cells.…”

Section: Discussionsupporting

confidence: 91%

“…Taken together, the results presented above and the fact that endogenous opioids have been described to modulate the immune response [53,54,66,67], lead to the following hypothesis regarding opioid effects on B-cells: B-lymphocytes are under Figure 6 Modification of the phosphorylation of specific signaling molecules by opioids. Left Panel: U266 (left column) or circulating CD19+ B-lymphocytes (right column) were incubated for the indicated time-periods with 10 − 6 M EKC.…”

Section: Discussionmentioning

confidence: 69%

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Opioids modulate constitutive B-lymphocyte secretion

Vassou

Bakogeorgou

Kampa

et al. 2008

International Immunopharmacology

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 69%

Opioids modulate constitutive B-lymphocyte secretion

Vassou

Bakogeorgou

Kampa

et al. 2008

International Immunopharmacology

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“…It has been shown that opioid peptides like f6-endorphin can affect mediator release of peritoneal mast cells (Mediratta et al, 1988;Sydbom, 1988). However, these data cannot be directly extrapolated to the airways due to tissue-related mast cell heterogeneity (Shanahan et al, 1984;Bienenstock, 1988).…”

Section: Resultsmentioning

confidence: 97%

Epithelium‐dependent potentiation of anaphylactic contractions by β‐endorphin in tracheae isolated from actively sensitized guinea‐pigs

Oosterhout

Čeleda

Delsman

et al. 1991

British J Pharmacology

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1 It has been shown that opioid peptides modulate airway function. In the present study, the effect of fi-endorphin on antigen-induced contractions of isolated tracheal rings from actively sensitized guineapigs has been studied. 2 /5-Endorphin had a concentration-dependent bimodal effect on anaphylactic contractions of the trachea. Low concentrations of fi-endorphin (10-10 and 10-8M) significantly potentiated anaphylactic contractions, whereas higher concentrations (10-v and 1-6M) significantly suppressed anaphylactic contractions of guinea-pig trachea. 6 In epithelium-denuded tracheae, both 10-8 and 10-7 M f-endorphin suppressed the anaphylactic contractions, whereas 10-8 and 10-7M des-Tyr'-fJ-endorphin did not affect anaphylactic contractions. It is concluded that the potentiation of the anaphylactic contraction in intact trachea is epithelium-dependent whereas the suppression of the anaphylactic contraction is epithelium-independent.

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“…The opioid pcptide fi-endorphin is secreted by thc pituitary gland during exercise and stress [2,3]. Since it has been shown that opioid peptides induce histamine release from rat peritoneal mast cells [4] and enhance IgE-mediated histamine release [5], a role for fi-endorphin in exacerbations of asthma during stress and exercise may be suggested. However, airway mast cells differ from peritoneal mast cells [6].…”

Section: Introductionmentioning

confidence: 99%

β-Endorphin modulates anaphylactic contractions of tracheae isolated from actively sensitized guinea pigs

et al. 1990

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It has been shown that opioid peptides induce histamine release and enhance antigen-induced histamine release from isolated peritoneal mast cells. Little is known about the effect of opioid peptides on mast cells present in airway smooth muscle. In the present study, the effect of beta-endorphin on antigen-induced contractions of isolated tracheal rings from actively sensitized guinea pigs was studied. It appears that beta-endorphin has a bidirectional effect on anaphylactic contractions of the trachea. Low concentrations of beta-endorphin (0.1 and 10 nM) significantly potentiate the anaphylactic contractions of tracheal rings. In contrast, higher concentrations of beta-endorphin (0.1 and 1 microM) significantly suppress the anaphylactic contractions of guinea pig trachea. In the presence of the non-selective opioid receptor antagonist naloxone, 10 nM of beta-endorphin still potentiates the anaphylactic contractions of the trachea. This demonstrates that the potentiation of anaphylactic contractions of guinea pig trachea by low concentrations of beta-endorphin is not mediated by opioid receptors. We speculate that the potentiation of the anaphylactic contraction by beta-endorphin is due to an interaction with mast cells.

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Modulation of humoral immune responses by endogenous opioids

Cited by 18 publications

References 13 publications

Opioids modulate constitutive B-lymphocyte secretion

Opioids modulate constitutive B-lymphocyte secretion

Epithelium‐dependent potentiation of anaphylactic contractions by β‐endorphin in tracheae isolated from actively sensitized guinea‐pigs

β-Endorphin modulates anaphylactic contractions of tracheae isolated from actively sensitized guinea pigs

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