Modulation of histidine decarboxylase activity and cytokine synthesis in human leukemic cell lines

Dy, Michel; Pacilio, Maria; Arnould, Anne; Machavoine, François; Mayeux, Patrick; Hermine, Olivier; Bodger, MP; Schneider, Elke

doi:10.1016/s0301-472x(99)00070-3

Cited by 22 publications

(17 citation statements)

References 40 publications

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“…IFN-␥, IL-1␤, and IL-6 were not detected, while they are also thought to be hepatic injury-related cytokines (14,(23)(24)(25)(26) and rubratoxin B actually elevated serum IL-6 levels in mice (9). It is known that IL-6 is one of the typical basophil-derived cytokines (27). Accordingly, it is likely that HL60 cells (not basophil-like cell line) do not produce IL-6.…”

Section: Discussionmentioning

confidence: 95%

Hepatotoxin Rubratoxin B Induced the Secretion of TNF-α, IL-8, and MCP-1 in HL60 Cells

Nagashima

Nakamura

Goto

2001

Biochemical and Biophysical Research Communications

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Section: Discussionmentioning

confidence: 95%

Hepatotoxin Rubratoxin B Induced the Secretion of TNF-α, IL-8, and MCP-1 in HL60 Cells

Nagashima

Nakamura

Goto

2001

Biochemical and Biophysical Research Communications

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“…Oligonucleotide primers for human IL-6 (260 bp) and ␤ 2 -microglobulin (180 bp) were produced by M. Dy (25). The housekeeping gene ␤ 2 -microglobulin was used as reference for the quantification of the IL-6 transcripts.…”

Section: Measurement Of Il-6 and Il-10 Mrna Production By Rt-pcrmentioning

confidence: 99%

Recruitment of STAT3 for Production of IL-10 by Colon Carcinoma Cells Induced by Macrophage-Derived IL-6

Herbeuval¹,

Lelièvre

Lambert³

et al. 2004

The Journal of Immunology

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100

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The immunosuppressive cytokine IL-10 is associated with poor prognosis in colon cancer. Although macrophages are involved in antitumor defenses, production of IL-10 by tumor cells may permit malignant cells escape to cell-mediated immune defenses. To investigate interactions between macrophages and tumor cells in humans, we cultured macrophages isolated from patients and tested the effect of these macrophages on the production of IL-10 by several tumor cell lines. Macrophages were isolated from pleural effusions of patients with malignancy and from noncancer control patients. We demonstrated that culture supernatants of macrophages from both sources strongly stimulated IL-10 production by the three different human colon adenocarcinoma cell lines, Colo 205, Colo 320, and HT29. Recombinant IL-6, but not IL-10, TNF-α, and IFN-α, stimulated the secretion of IL-10 by colon tumor cells. mAbs against IL-6 and IL-6R prevented the effect of macrophage culture supernatants and of rIL-6, respectively, on the production of IL-10 by the three cell lines. Cocultures of macrophages and colon cancer cells showed that these tumor cells first stimulated macrophages to produce IL-6, which was then followed by IL-6-induced IL-10 production by colon cancer cells. Finally, we showed that IL-10 gene regulation was mediated by STAT3, which was phosphorylated after the binding of IL-6 to IL-6R. This is the first demonstration that IL-6, secreted by macrophages, can induce a STAT3-mediated IL-10 production by colon tumor cells.

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“…Basophils are the least common myeloid granulocyte in the PB and have an important role in allergic inflammation, although the precise mechanisms involved are still not known [1][2][3][4]. Basophilia, which refers to an increase in the number of basophils, is commonly seen in infections, allergies, endocrinopathies, iron deficiency anemia, and malignancies.…”

Section: Introductionmentioning

confidence: 99%

De novo CD5+ diffuse large B cell lymphoma with basophilia in the peripheral blood: Successful treatment with autologous peripheral blood stem cell transplantation

et al. 2006

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Basophils play an important role in allergic inflammation and are pathologically related to hematological disturbances, such as iron deficiency anemia and myeloproliferative disorders; however, they are only rarely encountered in lymphoid malignancies. Here, we report the case of a 33-year-old man with a bulky mass of the small intestine, multiple paraaortic lymphoadenopathy, pleural effusion, and ascites, who was diagnosed as a case of de novo CD5+ diffuse large B cell lymphoma (DLBCL). This patient showed a marked elevation of the basophil count in the peripheral blood, which appeared to run in parallel with the tumor burden. High dose chemotherapy followed by autologous peripheral blood cell transplantation yielded complete remission, and the patient has remained disease free for 5 years. To the best of our knowledge, this is the first report of a case of de novo CD5+ DLBCL showing marked elevation of the PB basophil count. Am. J. Hematol. 82:162-167, 2007.Wiley-Liss, Inc.

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Modulation of histidine decarboxylase activity and cytokine synthesis in human leukemic cell lines

Cited by 22 publications

References 40 publications

Hepatotoxin Rubratoxin B Induced the Secretion of TNF-α, IL-8, and MCP-1 in HL60 Cells

Hepatotoxin Rubratoxin B Induced the Secretion of TNF-α, IL-8, and MCP-1 in HL60 Cells

Recruitment of STAT3 for Production of IL-10 by Colon Carcinoma Cells Induced by Macrophage-Derived IL-6

De novo CD5+ diffuse large B cell lymphoma with basophilia in the peripheral blood: Successful treatment with autologous peripheral blood stem cell transplantation

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