De novo CD5+ diffuse large B cell lymphoma with basophilia in the peripheral blood: Successful treatment with autologous peripheral blood stem cell transplantation

Tokuhira, Michihide; Watanabe, Reiko; Iizuka, Akira; Sekiguchi, Y.; Nemoto, Tomoe; Hanzawa, Kyoto; Takamatsu, Ichiro; Maruyama, Taro; Tamaru, Jun Ichi; Itoyama, Shinji; Suzuki, Hiroshi; Takeuchi, Tsutomu; Mori, Shiro

doi:10.1002/ajh.20786

Cited by 6 publications

(3 citation statements)

References 19 publications

(23 reference statements)

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“…[1] The significantly increased absolute neutrophil count in anemic patients in the present study could possibly be due to compensatory activity due to inhibition in the capability to phagocytose. [2][3][4][5][6] In the present study, significant lymphopenia in anemic group is well correlated with some studies done in the past. The lymphopenia could be due to reduction in the lifespan of lymphocytes secondary to oxidative damage.…”

Section: Discussionsupporting

confidence: 85%

Association of nutritional anemia with leukocyte and platelet counts in people of Odisha

Samanta¹,

Senapati²

2017

Natl J Physiol Pharm Pharmacol

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Background: Anemia is the most common hematological disorder in the world, due to deficiency of micronutrients such as iron, Zn, Se, Cu, folic acid, and vitamins. Iron deficiency impairs immune response and bactericidal activity of macrophages, monocytes, and neutrophils that alters the length and quality of life. Leukocyte count may be altered due to hypoxia and ischemia, which is seen in anemia. A strong association between leukocyte counts and ischemia is seen from the experimental and clinical studies. Aims and Objectives: The present study was aimed to estimate total leukocyte count (TLC) and differential leukocyte count (DLC), neutrophil-to-lymphocyte ratio (N/L ratio), and platelet count in anemia. N/L ratio has emerged as a useful index in ischemic heart disease (IHD). Materials and Methods: A total of 30 patients of nutritional anemia in both the sexes were taken as study group, whose hemoglobin level was <6 g%, and they were compared with 30 healthy subjects of same age group. The parameters studied were TLC, DLC, N/L ratio, and platelet count. Results: TLC is insignificantly higher in anemic subjects. DLC shows, significant rise in absolute neutrophil count (P < 0.005), fall in absolute lymphocyte count significantly (P < 0.005), and rise in eosinophil and basophil count which is not statistically significant. There is not much difference in monocyte count in both groups. Associated poikilocytosis and anisocytosis of red blood cells are present in anemic subjects. N/L ratio is significantly higher in anemics (P < 0.001). Platelet count is decreased significantly in patients of anemia than control subjects (P < 0.001). Conclusions: Thus, our study highlights that, immunity especially cellular immunity, is influenced by nutritional anemia. High N/L ratio in anemia is associated with IHD and severe anemia is also associated with thrombocytopenia.

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Section: Discussionsupporting

confidence: 85%

Association of nutritional anemia with leukocyte and platelet counts in people of Odisha

Samanta¹,

Senapati²

2017

Natl J Physiol Pharm Pharmacol

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“…This study confirms the poor prognosis of de novo CD5+ DLBCL in a large multi-center cohort despite initial rituximab-containing chemotherapy and suggests that stem cell transplantation fails to salvage the majority of these patients. However, Tokuhira M et al [33] reported a successful treatment with autologous peripheral blood stem cell transplantation (APBSCT), they described the clinical course of a young Japanese man with de novo CD5+ DLBCL who showed marked elevation of the PB basophil count, and documented the clinical results and suggested that some salvage therapy, including APBSCT, may have the potential to cure the condition. From all parts mentioned above, it is worthy of note that de novo CD5+ DLBCL is associated with higher proliferative activity and a poorer prognosis.…”

Section: Discussionmentioning

confidence: 99%

Clinicopathologic significance and therapeutic implication of de novo CD5+ diffuse large B-cell lymphoma

et al. 2019

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Background: Various subsets of diffuse large B-cell lymphoma(DLBCL) are distinguished based on molecular and immunohistochemical features. As we know, CD5 is a panT cell surface marker and is seldom expressed in DLBCL. Large-scale studies of de novo CD5+ DLBCL are lacking in Chinese patients. Method: A total of 139 patients with DLBCL (30 CD5+ DLBCL and 109 CD5− DLBCL) who were immunophenotyped and treated with chemotherapy were subjected to this analysis. There were 85 males and 54 females. Their age ranged from 17 to 84 years old, and the median age was 58 years old. Results: In this study CD5+ DLBCL was associated with higher IPI scores (>2), bone marrow involvement, higher probability of >1 ECOG performance status, non-germinal center B-cell like(non-GCB), BCL2 overexpression, whereas seldom expressed CD10 or BCL6, and unconspicuous higher expression of Ki67. With standard chemotherapy, CD5+ DLBCL patients had significantly worse overall survival (OS, median, 29.5 months vs. not reached, P = 0.0004) and progression-free survival (PFS, median, 18.0 months vs. not reached, P = 0.0002) than CD5− DLBCL patients, which had independent prognostic significance of the International Prognostic Index (IPI), and subtype of the non-GCB DLBCL. For CD5+ DLBCL, the addition of rituximab to chemotherapy may not significantly improve the OS (median, 14 months vs. 29.5 months, P = 0.72) and PFS (median, 10 months vs. 12 months, P = 0.92). Conclusion: CD5+ DLBCL patients have the distinctive clinical and biological features, they should be provided with clinic individualized treatment and important pathways with therapeutic implications should be underscored.

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“…Basophilia is extremely rare in patients with lymphoid lymphoma. Tokuhira et al reported an unusual case of a patient with de novo CD5+ lymphoma and basophilia . The basophil count never exceeded 1 × 10 9 /L and basophilia was not a key feature that leads the physician to diagnose the lymphoid neoplasm.…”

Section: Looking For a Neoplastic Basophiliamentioning

confidence: 99%

How I investigate basophilia in daily practice

Feriel

Depasse

Geneviève

2019

Int J Lab Hematology

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Basophilia is a rare disorder of the complete blood count (CBC) and its management in daily practice remains unclear. Two main factors explain this situation. On the one hand, the reliability of the basophil count is insufficient, whether it is performed by a microscopic slide examination or by a hematology analyser. On the other hand, our knowledge of conditions associated with basophilia is largely based on few case reports and on reviews that refer to older reviews. The association between basophilia and myeloid neoplasm, especially chronic myeloid neoplasm, is well established.Conversely, there are conflicting data on some benign medical conditions and it remains unclear where basophilia may be present. In this review, we have investigated the medical literature to define which medical conditions can lead to basophilia and which cannot, and we propose a practical approach to manage basophilia divided into 3 steps. First, we have to check the real existence of the basophilia by getting rid of spurious basophilia. Then, we have to look for symptoms that suggest reactive basophilia and for clue of a neoplastic cause. Finally, in case of suspicion of a myeloid neoplasm or persistence of the basophilia in the absence of a reactive cause, we have to decide which examinations need to be prescribed to confirm a neoplastic basophilia. K E Y W O R D Satopy, basophilia, blood smear, chronic myeloid leukemia (CML), flow cytometry, pseudobasophilia

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De novo CD5+ diffuse large B cell lymphoma with basophilia in the peripheral blood: Successful treatment with autologous peripheral blood stem cell transplantation

Cited by 6 publications

References 19 publications

Association of nutritional anemia with leukocyte and platelet counts in people of Odisha

Association of nutritional anemia with leukocyte and platelet counts in people of Odisha

Clinicopathologic significance and therapeutic implication of de novo CD5+ diffuse large B-cell lymphoma

How I investigate basophilia in daily practice

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