Modulation of Gro-α and Tnf-α Production by Peripheral Blood Mononuclear Cells Treated with Killed Helicobacter Pylori

Stassi, Giovanna; Iaria, Chiara; Gazzara, D; Costa, G.B.; Iannello, D; Arena, Adriana

doi:10.1177/1721727x0700500204

Cited by 10 publications

(10 citation statements)

References 16 publications

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“…Initially, TRAILinduced apoptosis pathway involves the activation of caspase-8 that triggers the activation of the effector enzyme, caspase-3, responsible for the proteolytic cleavage of CADIICAD complex. Once CAD is free, it starts DNA degradation that leads to apoptosis (21)(22)(23)(24)(25). TRAIL is expressed by many cell types such as T and B lymphocytes, dendritic and NK cells.…”

mentioning

confidence: 99%

Osteoblast Apoptosis in Periodontal Disease: Role of TNF-Related Apoptosis-Inducing Ligand

Mori

Brunetti

Colucci

et al. 2009

Int J Immunopathol Pharmacol

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Periodontal disease (Pd) is characterized by an increased osteoclast resorption and a decreased osteoblast (OB) bone formation. OBs obtained from alveolar bone of Periodontitis patients (Pp) undergo apoptosis in the presence of TNF-related apoptosis-inducing ligand (TRAIL). We studied the intracellular apoptotic pathway induced by TRAIL; TRAIL death (DR4, DRS) and decoy (DcRl, DcR2) receptors expression in Periodontitis patients' OBs (PpOBs), and we measured the concentration of TRAIL in the serum of Pp. We demonstrated that DNA fragmentation and activation of caspase-8 and caspase-3 in PpOBs, following TRAIL stimulation, occurred in shorter time; moreover, a higher amount of both caspases was activated in order to direct OBs. Down-regulation of DcR2 in PpOBs was demonstrated and high TRAIL levels were detected in the serum of Pp. In conclusion, our data suggest that PpOBs are more sensitive to TRAIL-induced apoptosis when compared to the control group. The down-regulation of DcR2 possibly leads to an imbalanced ratio between death and decoy receptors. Our findings highlight a role of TRAIL in the pathogenesis of Pd.Periodontal disease, defined as a plaque-induced inflammation of the periodontal tissues, results in alveolar bone loss supporting the affected teeth and is considered the most frequent cause of tooth loss among adults (1-2). Destruction of the periodontal attachment apparatus, increased bone resorption with loss of crestal alveolar bone, apical migration of the epithelial attachment, and formation of periodontal pockets characterize the disease process (1-8). Bone remodelling is a multi-step and tightly regulated process leading to the coordinated action of bone forming cells, osteoblasts (OBs), and bone resorbing cells, osteoclasts. In the bone microenvironment, the balance between osteoclast and OB activity depends upon the ratio of their proliferation and apoptosis, thus determining the prevalence ofbone formation or resorption. Abnormality in the apoptosis regulation of bone cells can promote osteolytic bone disorders (9-11).TNF-related apoptosis-inducing ligand (TRAIL),

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confidence: 99%

Osteoblast Apoptosis in Periodontal Disease: Role of TNF-Related Apoptosis-Inducing Ligand

Mori

Brunetti

Colucci

et al. 2009

Int J Immunopathol Pharmacol

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“…Inclusion criteria for the study required a III or IV degree of AH in each patient at the initial endoscopic examination (19)(20)(21)(22).…”

Section: Study Populationmentioning

confidence: 99%

Hypertonic Saline Solution in Children with Adenoidal Hyperytrophy: Preliminary Evidence

Ciprandi

Varricchio

Capasso³

et al. 2007

Eur J Inflamm

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Adenoidal hypertrophy (AH) is a frequent problem in children. A preliminary study evidenced that intranasal hypertonic solutions may exert an anti-inflammatory activity. The aim of the study is to evaluate the effect of intranasal hypertonic or isotonic solutions in children affected with AH. For this purpose, 78 children with AH were evaluated in a randomised and controlled study. Inclusion criteria for the study required that each patient had to have a III or IV degree of AH on the initial endoscopic examination. Children were treated with intranasal hypertonic or isotonic saline solution for 8 weeks. After treatment, endoscopy was performed to evaluate AH degree. Hypertonic treatment was associated with significant (p

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“…Attachment of the c-peptide to the cellular surface takes place through a pair of G-type protein receptors, thus causing the stimulation of special intracellular processes (16)(17)(18)(19)(20).…”

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confidence: 99%

“…There are significant interactions between cpeptide and cell membrane, while there is direct evidence of a stereospecific binding of the peptide with its receptor, which is different from the receptor of insulin and other relevant hormones. Attachment of the c-peptide to the cellular surface takes place through a pair of G-type protein receptors, thus causing the stimulation of special intracellular processes (16)(17)(18)(19)(20).…”

mentioning

confidence: 99%

The Effect of Porcine Orexin a on C-Peptide Plasma Concentrations in Pigs

Papakonstantinou

Tziris²,

Κεσίσογλου

et al. 2007

Eur J Inflamm

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The hypothalamus and the neuropeptides that are produced and act within its neuronal circuits constitute an area of extensive laboratory research. In 1998, the neuropeptide, Orexin A, was discovered and isolated from the hypothalamus of the rat. An i.c.v. injection of Orexin A into the lateral ventricle of the rat's brain causes an increase in the consumption of food, and, apart from appetite, it also seems to be regulating many other normal functions of the organism, whose regulatory and metabolic mechanisms remain unknown to date. The neuropeptide is produced by a small cluster located in and round the lateral hypothalamic area. It has been known for decades that this area is involved in the regulation of feeding and energy homeostasis in mammals. The intravenous, subcutaneous, or i.c.v. injection of Orexin A causes changes in insulin and glucagon concentrations. The same effect is also seen under in vitro experimental conditions. In this study, we investigated the potential effects of i.c.v. administration of porcine Orexin A on c-peptide concentrations in the peripheral blood of pigs, and tested whether these changes are associated with the potential effect of the neuropeptide on the function of the pancreas.

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Modulation of Gro-α and Tnf-α Production by Peripheral Blood Mononuclear Cells Treated with Killed Helicobacter Pylori

Cited by 10 publications

References 16 publications

Osteoblast Apoptosis in Periodontal Disease: Role of TNF-Related Apoptosis-Inducing Ligand

Osteoblast Apoptosis in Periodontal Disease: Role of TNF-Related Apoptosis-Inducing Ligand

Hypertonic Saline Solution in Children with Adenoidal Hyperytrophy: Preliminary Evidence

The Effect of Porcine Orexin a on C-Peptide Plasma Concentrations in Pigs

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