Modulation of genotoxicity and DNA repair by plant monoterpenes camphor, eucalyptol and thujone in Escherichia coli and mammalian cells

Nikolić, Biljana; Mitić-Ćulafić, Dragana; Vuković-Gačić, Branka; Knežević-Vukčević, Jelena

doi:10.1016/j.fct.2011.05.015

Cited by 57 publications

(31 citation statements)

References 58 publications

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“…These effects were attributed to inhibition of protein synthesis [58]. According to obtained results we proposed that, by retaining bacterial growth and cell divisions, Thu increased the time for error free repair of pyrimidine dimers by NER, similarly as Lin.…”

Section: Bioantimutagenic Potential Of Camphor Eucalyptol and Thujonementioning

confidence: 83%

“…Since sfiA is under SOS regulation, the level of -galactosidase in these strains reflects the level of SOS induction [65]. Both strains are constitutive for alkaline phosphatase, allowing simultaneous assessment of SOS induction and overall protein synthesis [56,58].…”

Section: E Coli Assay For Bioantimutagensmentioning

confidence: 99%

“…In order to elucidate the mechanisms involved in strong bioantimutagenic potential of Cam, Euc and Thu, we further analyzed their effect on DNA repair processes [58].…”

Section: Bioantimutagenic Potential Of Camphor Eucalyptol and Thujonementioning

confidence: 99%

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Molecular Mechanisms of Action of Antimutagens from Sage (Salvia officinalis) and Basil (Ocimum basilicum)

Nikolić¹,

Mitić-Ćulafić²,

Vuković-Gačić³

et al. 2012

Mutagenesis

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Section: Bioantimutagenic Potential Of Camphor Eucalyptol and Thujonementioning

confidence: 83%

Section: E Coli Assay For Bioantimutagensmentioning

confidence: 99%

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Molecular Mechanisms of Action of Antimutagens from Sage (Salvia officinalis) and Basil (Ocimum basilicum)

Nikolić¹,

Mitić-Ćulafić²,

Vuković-Gačić³

et al. 2012

Mutagenesis

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“…GS4d2II1a were previously reported. For example, the monoterpene eucalyptol or 1,8-cineol is a constituent of essential oils of many medicinal and aromatic plants, with antimicrobial [43] and antifungal activity against Aspergillus flavus, Aspergillus parasiticus [44], Aspergillus niger [45], and Sclerotinia sclerotiorum. Furthermore, a fuel potential has been ascribed to this compound [20].…”

Section: Ecological Function and Biological Activity Of Identified Vocsmentioning

confidence: 99%

Antifungal Volatile Organic Compounds from the Endophyte Nodulisporium sp. Strain GS4d2II1a: a Qualitative Change in the Intraspecific and Interspecific Interactions with Pythium aphanidermatum

Sánchez-Fernández

Díaz²,

Duarte³

et al. 2015

Microb Ecol

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This study demonstrates volatile organic compounds (VOCs) production as one of the defense mechanisms of the antagonistic endophyte Nodulisporium sp. GS4d2II1a, and the volatile changes in two times of the fungal growth; and, as result of its intra and interspecific interactions with the plant pathogen Pythium aphanidermatum. The antifungal activity of the volatile and diffusible metabolites was evaluated by means of three types of antagonism bioassays and by organic extract agar dilution. VOCs were obtained by gas chromatography coupled to mass spectrometry from 3- and 5-day Nodulisporium sp. cultures, as well as from its interspecific in vitro antagonistic interaction with the oomycete P. aphanidermatum, and its intraspecific Nodulisporium sp.-Nodulisporium sp. interaction. The GS4d2II1a strain completely inhibited the growth of two fungi and seven oomycetes by replacing their mycelia in simple antagonism bioassays and by producing in vitro volatile and diffusible metabolites that acted synergistically in multiple antagonism bioassays. Additionally, VOCs inhibited the growth of three oomycetes and one fungus in antagonism bioassays using divided plates. A total of 70 VOCs were detected, mainly including mono and sesquiterpenes, especially eucalyptol and limonene. Multiple correspondence analysis revealed four different volatile profiles, showing that volatiles changed with the fungus age and its intra and interspecific interactions. The metabolites produced by Nodulisporium sp. GS4d2II1a could be useful for biological control of fungal and oomycetes plant pathogens of economically important crops.

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“…Szczot et al (Szczot et al, 2012) also showed that GABA-inhibition dosage of (À)-a-thujone is unlikely to be achieved in a dietary context. On the other hand, recent in vivo studies revealed that isomers of thujone exhibit antitumor (Biswas et al, 2011;Nikolic et al, 2011;Siveen and Kuttan, 2011b) and immunostimulate (Siveen and Kuttan, 2011a) activities as well as decrease levels of cholesterol and improve lipid profile in blood of diabetic rats (Baddar et al, 2011).…”

Section: Introductionmentioning

confidence: 98%

Microbial transformations of (−)-α- and (+)-β-thujone by fungi of Absidia species

Gniłka

Majchrzak

Wawrzeńczyk

2015

Phytochemistry Letters

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Modulation of genotoxicity and DNA repair by plant monoterpenes camphor, eucalyptol and thujone in Escherichia coli and mammalian cells

Cited by 57 publications

References 58 publications

Molecular Mechanisms of Action of Antimutagens from Sage (Salvia officinalis) and Basil (Ocimum basilicum)

Molecular Mechanisms of Action of Antimutagens from Sage (Salvia officinalis) and Basil (Ocimum basilicum)

Antifungal Volatile Organic Compounds from the Endophyte Nodulisporium sp. Strain GS4d2II1a: a Qualitative Change in the Intraspecific and Interspecific Interactions with Pythium aphanidermatum

Microbial transformations of (−)-α- and (+)-β-thujone by fungi of Absidia species

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