Modulation of Ganciclovir Intestinal Absorption in Presence of Absorption Enhancers

Shah, Pranav; Jogani, Viral; Mishra, Pushpa; Mishra, Anil K.; Bagchi, Tamishraha; Misra, Ambikanandan

doi:10.1002/jps.20888

Cited by 30 publications

(18 citation statements)

References 58 publications

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“…Various in vivo studies can be used to confirm this permeation enhancing effect. A 2-fold improvement of the oral bioavailability of ganciclovir was demonstrated owing to the coadministration of chitosan [58].…”

Section: Permeation Enhancing Propertiesmentioning

confidence: 99%

Impact of chitosan composites and chitosan nanoparticle composites on various drug delivery systems: A review

Elgadir

Uddin

Ferdosh

et al. 2015

Journal of Food and Drug Analysis

435

186

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Chitosan is a promising biopolymer for drug delivery systems. Because of its beneficial properties, chitosan is widely used in biomedical and pharmaceutical fields. In this review, we summarize the physicochemical and drug delivery properties of chitosan, selected studies on utilization of chitosan and chitosan-based nanoparticle composites in various drug delivery systems, and selected studies on the application of chitosan films in both drug delivery and wound healing. Chitosan is considered the most important polysaccharide for various drug delivery purposes because of its cationic character and primary amino groups, which are responsible for its many properties such as mucoadhesion, controlled drug release, transfection, in situ gelation, and efflux pump inhibitory properties and permeation enhancement. This review can enhance our understanding of drug delivery systems particularly in cases where chitosan drug-loaded nanoparticles are applied.

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Section: Permeation Enhancing Propertiesmentioning

confidence: 99%

Impact of chitosan composites and chitosan nanoparticle composites on various drug delivery systems: A review

Elgadir

Uddin

Ferdosh

et al. 2015

Journal of Food and Drug Analysis

435

186

View full text Add to dashboard Cite

show abstract

“…These results may be attributed to the higher dissolution rate of the drug from the lyophilized system. Moreover, the gastrointestinal absorption of gliclazide was likely to be enhanced by the effect of SLS that enhances drug transepithelial permeation and bioavailability as reported in literature 35 . SLS acts by causing a temporary drop in oxidative phosphorylation leading to decrease in cellular ATP levels.…”

Section: Discussionmentioning

confidence: 81%

In vitroevaluation andin vivoperformance of lyophilized gliclazide

Mansour

Aly

2014

Drug Development and Industrial Pharmacy

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Enhancement of the dissolution rate of the poorly water-soluble hypoglycemic agent, gliclazide, by the aid of lyophilization was investigated. Mannitol, sodium lauryl sulfate (SLS) and polyvinyl pyrrolidone (PVP-k-30) were employed in different weight ratios (43%, 56% and 64% w/w, respectively) as water-soluble excipients in the formulation. Lyophilized systems were found to exhibit extremely higher in vitro dissolution rate compared to the unprocessed drug powder. Solid state characterization of the lyophilized systems using X-ray powder diffraction, Fourier transform infrared spectroscopy and differential scanning calorimetry techniques revealed that dissolution enhancement was attributable to transformation of gliclazide from the crystalline to an amorphous state in the solid dispersion formed during the lyophilization process. The gastrointestinal absorption and hypoglycemic effect of the lyophilized gliclazide/SLS system were investigated following oral administration to Albino rabbits. Cmax and area under the plasma concentration-time curve of gliclazide (AUC0-12) after administration of the lyophilized formulations were significantly higher than those obtained after administration of the unprocessed gliclazide.

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“…It is well known that CDs enhance the absorption by increased solubilization and dissolution of the drug . The permeation-enhancing effect of CD was also identified in vitro cell monolayer system like Caco-2 cell monolayer (Shah et al, 2007). The higher permeation profile of F2 might be due to enhanced dissolution by the synergistic result of CMC-Na and HP-␤-CD.…”

Section: In Vitro Permeation Studymentioning

confidence: 93%

Characterization and in vitro evaluation of freeze-dried microparticles composed of granisetron–cyclodextrin complex and carboxymethylcellulose for intranasal delivery

Cho

Balakrishnan

Shim

et al. 2010

International Journal of Pharmaceutics

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Modulation of Ganciclovir Intestinal Absorption in Presence of Absorption Enhancers

Cited by 30 publications

References 58 publications

Impact of chitosan composites and chitosan nanoparticle composites on various drug delivery systems: A review

Impact of chitosan composites and chitosan nanoparticle composites on various drug delivery systems: A review

In vitroevaluation andin vivoperformance of lyophilized gliclazide

Characterization and in vitro evaluation of freeze-dried microparticles composed of granisetron–cyclodextrin complex and carboxymethylcellulose for intranasal delivery

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