Impact of chitosan composites and chitosan nanoparticle composites on various drug delivery systems: A review

Elgadir, M. Abd; Uddin, Md. Azhar; Ferdosh, Sahena; Adam, Aishah; Chowdhury, Ahmed Jalal Khan; Sarker, Zaidul Islam

doi:10.1016/j.jfda.2014.10.008

Cited by 435 publications

(204 citation statements)

References 118 publications

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“…Although the GIT is designed (evolved) to prevent uptake of particulate matter (e.g. potentially toxic materials and pathogens) from the environment, it is not a completely prohibitive barrier [9][10][11] . The chemical composition of mucus provides an opportunity for both acidic and basic compounds to interact with it, thereby increasing the residence time of both drugs and NPs in close proximity to the absorptive surfaces.…”

Section: Gastrointestinal Tract (Git) Physiology With Relevance To Pamentioning

confidence: 99%

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2017

IJPSR

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Peptide drugs are poorly absorbable and are also susceptible to enzymatic degradation in the gastrointestinal tract (GIT). To overcome the physiological and morphological barriers for the peptide / poorly absorbable drug delivery, mucopenetrative and mucoadhesive properties of drug carriers have to be considered. Mucoadhesion can prolong the residence time of drug carriers at the absorption sites, improved drug absorption and controlled release of drug from the device used. The particles with smaller size were likely to diffuse much faster into the mucus layer, provided that diffusion of the particles into the mucus layer should obey Stokes-Einstein equation. The adhesiveness of the nanoparticles (NPs) in suspension form helps to improve bioavailability. Chitosan (CS) based or CS-coated NPs represent another common group of mucoadhesive systems. Moreover, NPs made of such polymers were used to enhance the bioavailability, and also the mucoadhesion of proteins, peptides and DNA to the mucosal tissues. This review focuses on the mechanism of gastrointestinal mucoadhesion of NPs for peptide/poorly absorbable drugs.

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Section: Gastrointestinal Tract (Git) Physiology With Relevance To Pamentioning

confidence: 99%

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2017

IJPSR

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“…These results are in agreement with other reports on TMC based nanovectors with low toxicity 46 and also show a correlation of the cytotoxicity with other structural parameters besides surface charge, like size of the 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 nanoparticles, molecular weight of chitosan and acetylation degree. 47 Moreover, the lowered buffering capacity of chitosan after methylation 5 prevents endo-lysosomal disruption and scape, 48 which in combination with the dissociation capacity of the PECs at low pH 5 and the eventual TMC degradation by lysosomal enzymes, 49 may preserve lysosomal function after PECs internalization.…”

Section: Specific Enzymatic Activity and Activity In Primary Culturesmentioning

confidence: 99%

Highly Versatile Polyelectrolyte Complexes for Improving the Enzyme Replacement Therapy of Lysosomal Storage Disorders

Giannotti

Abasolo

Oliva

et al. 2016

ACS Appl. Mater. Interfaces

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“…Se compone principalmente de un polímero de unidades -(1-4)-2-amino-2-desoxi-D-glucosa (Cissé et al, 2012;Da Silva et al, 2012). Actualmente, el quitosano es un polímero que juega un papel importante en la economía mundial ya que es biodegradable (Elgadir et al, 2015) comestible y antimicrobiano (Martelli et al, 2013). Por otro lado, se puede usar para formar películas que actúan como barrera contra la humedad (Leceta et al, 2014) y utilizarse como recubrimiento de frutas y hortalizas ) para la elaboración de productos listos para comer (Jirukkakul, 2013).…”

Section: Introductionunclassified

Effect of essential oil of Cymbopogon citratus in the physicochemical properties of quitosan films

Vázquez-Briones

Guerrero-Beltrán

2017

Sci.agropec

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ResumenSe investigó el efecto de la incorporación de aceite esencial de zacate limón (Cymbopogon citratus), en concentraciones de 0, 200 y 400 ppm, en las propiedades fisicoquímicas (espesor, humedad, solubilidad, permeabilidad al vapor de agua, color, transparencia) y mecánicas (resistencia a la tensión y elongación) de películas de quitosano a dos concentraciones (1 y 3%). Los resultados mostraron un efecto significativo (p ≤ 0,05) en los valores del espesor de las películas a las dos concentraciones de quitosano. Se observó un efecto significativo (p ≤ 0,05) en los valores de humedad a concentraciones de 0, 200 y 400 ppm de aceite esencial. La adición de aceite esencial en películas de quitosano mostró un efecto significativo (p ≤ 0,05) en los valores de permeabilidad al vapor de agua. La concentración de quitosano mostró un efecto significativo (p ≤ 0,05) en transparencia y en los parámetros de color L*, a*, b*. Al variar la concentración de quitosano se observó un incremento significativo (p ≤ 0,05) en los valores de resistencia a la tensión de las películas de quitosano.Palabras clave: películas comestibles; quitosano; Cymbopogon citratus; propiedades mecánicas; color. AbstractThe effect of the incorporation of lemon grass (Cymbopogon citratus) essential oil at concentrations of 0, 200 and 400 ppm in the physicochemical (thickness, moisture, solubility, water vapor permeability, color, transparency) and mechanical properties (tensile strength and elongation) of chitosan films at concentrations of 1 and 3% was assessed. Results showed a significant effect (p ≤ 0.05) on the thickness values of films at concentrations of 1 and 3% of chitosan. A significant effect (p ≤ 0.05) was observed in the moisture content at concentrations of 0, 200 and 400 ppm of essential oil. The addition of essential oil to chitosan films showed a significant change (p ≤ 0.05) in the water vapor permeability values. The chitosan concentration showed a significant effect (p ≤ 0.05) on transparency and the L*, a*, and b* color parameters. By varying the chitosan concentration, a significant increase (p ≤ 0.05) in the tensile strength values of the chitosan films was observed.

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Impact of chitosan composites and chitosan nanoparticle composites on various drug delivery systems: A review

Cited by 435 publications

References 118 publications

Untitled

Untitled

Highly Versatile Polyelectrolyte Complexes for Improving the Enzyme Replacement Therapy of Lysosomal Storage Disorders

Effect of essential oil of Cymbopogon citratus in the physicochemical properties of quitosan films

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