Modulation of error-sensitivity during a prism adaptation task in people with cerebellar degeneration

Hanajima, Ritsuko; Shadmehr, Reza; Ohminami, Shinya; Tsutsumi, Ryosuke; Shirota, Yasuhiko; Shimizu, Takahiro; Tanaka, Nobuyuki; Terao, Yasuo; Tsuji, Shoji; Ugawa, Yoshikazu; Uchimura, Motoaki; Inoue, Masato; Kitazawa, Shigeru

doi:10.1152/jn.00145.2015

Cited by 45 publications

(43 citation statements)

References 52 publications

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“…We found that selective reward facilitated saccade adaptation by increasing adaptation speed in one direction and not the other. Thus, although reward motivation is not necessary to induce saccade adaptation per se (Frens and van Opstal, 1994; Hopp and Fuchs, 2004), it apparently can speed that adaptation by increasing the sensitivity to the error in driving adaptation, i.e., how much the brain “learns” from a given error (Marko et al, 2012; Hanajima et al, 2015). …”

Section: Discussionmentioning

confidence: 99%

Selective reward affects the rate of saccade adaptation

Kojima

Soetedjo

2017

Neuroscience

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In this study we tested whether a selective reward could affect the adaptation of saccadic eye movements in monkeys. We induced the adaptation of saccades by displacing the target of a horizontal saccade vertically as the eye moved toward it, thereby creating an apparent vertical dysmetria. The repeated upward target displacement caused the originally horizontal saccade to gradually deviate upward over the course of several hundred trials. We induced this directional adaptation in both right- and leftward saccades in every experiment (n=20). However, in half of the experiments (n=10), we rewarded monkeys only when they made leftward saccades and in the other half only for rightward saccades. The reaction time of saccades in the rewarded direction was shorter and we, like others, interpreted this change as a sign of the reward’s preferential effect in that direction. Saccades in the rewarded direction showed more rapid adaptation of their directions than did saccades in the non-rewarded direction, indicating that the selective reward increased the speed of saccade adaptation. The differences in adaptation speed were reflected in changes in saccade metrics, which were usually more noticeable in the deceleration phases of saccades than in their acceleration phases. Because previous studies have shown that the oculomotor cerebellum is involved with saccade deceleration and also participates in saccade adaptation, it is possible that selective reward could influence cerebellar plasticity.

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Section: Discussionmentioning

confidence: 99%

Selective reward affects the rate of saccade adaptation

Kojima

Soetedjo

2017

Neuroscience

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“…The experimental procedures were the same as those reported previously . Participants were seated facing a 21‐inch electrostatic touch panel monitor positioned 300 mm from their eyes.…”

Section: Methodsmentioning

confidence: 99%

“…The experimental procedures were the same as those reported previously. 18,19 Participants were seated facing a 21-inch electrostatic touch panel monitor positioned 300 mm from their eyes. Visual occlusion spectacles with liquid crystal shutters (PLATO, Translucent Technologies, ON, Canada) were set in front of the eyes to prevent visual input from the finger movement during the task performance.…”

Section: Experiments 2: Prism Adaptation Taskmentioning

confidence: 99%

Cerebellar dysfunction in essential tremor

et al. 2016

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“…included an error-free period, thus permitting robust measurement of error sensitivity and forgetting 836 rates. In all cases, we measured the differences in error sensitivity for small (between 5° and 20°) and 837 large (between 20° and 30°) errors from the start (epoch 1) to the last epoch (epoch 60), predicted by 838…”

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confidence: 99%

An implicit memory of errors limits human sensorimotor adaptation

Albert

Jang

Sheahan

et al. 2019

Preprint

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22In many forms of motor adaptation, performance approaches a limit at which point learning stops, 23 despite the fact that errors remain. What causes this adaptation limit? Here we found that while reach 24 adaptation exhibited an asymptotic limit, this limit was not fixed: when the variance of the perturbation 25 decreased, the adaptation limit increased, and performance improved. Moreover, the limit could be 26 altered in real-time by changing perturbation variance. The same was true at low reaction times, 27indicating that implicit processes influenced the adaptation limit. Using a mathematical model that 28describes adaptation as a balance between learning and forgetting, we found that participants altered 29 their adaptation limit by changing their sensitivity to reaching errors. Changes in error sensitivity were 30 linked to the consistency of past errors. These observations suggest that during adaptation, time-varying 31 error sensitivities compete with constant forgetting, setting the boundary conditions that produce an 32 apparent limit in total adaptation. 33

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Modulation of error-sensitivity during a prism adaptation task in people with cerebellar degeneration

Abstract: S. Modulation of error-sensitivity during a prism adaptation task in people with cerebellar degeneration.

Cited by 45 publications

References 52 publications

Selective reward affects the rate of saccade adaptation

Selective reward affects the rate of saccade adaptation

Cerebellar dysfunction in essential tremor

An implicit memory of errors limits human sensorimotor adaptation

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