Modulation of DNA damage response by targeting ATM kinase using newly synthesized di-phenoxy acetamide (DPA) analogs to induce anti-neoplasia

Structural and theoretical exploration of a multi-methoxy chalcone: Synthesis, quantum theory, electrostatics, molecular packing, DFT analysis, and in-silico anti-cancer evaluation

“…Continual cancer research is enhancing our comprehension of the fundamental biology of various types of cancer, hence aiding the progress of precise treatments such as targeted medications and immunotherapies [ 3 ]. Furthermore, advancements in early detection techniques and precision treatment are enhancing the results for several individuals [ 4 ]. Cancer is a multifaceted disease, and tumours can exhibit substantial differences among patients and even within the same patient.…”

Synthesis, crystal structure, DFT, Hirshfeld surface analysis, energy frameworks and in-Silico drug-targeting PFKFB3 kinase of novel triazolequinoxalin derivative (TZQ) as a therapeutic Strategy against cancer

“…This requires a greater comprehension of the underlying mechanisms of cancer and the identification of new targets for therapy [ 5 ]. Additionally, research into personalized medicine, which tailors treatment to an individual's specific genetic and molecular makeup, holds great promise for improving cancer outcomes [ 6 , 7 ]. It's important to note that even with advanced-stage cancer, there is still hope for effective treatment and even remission in some cases [ 8 ].…”