2012
DOI: 10.1002/adfm.201103151
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Modulation of Dendritic Cells by Lipid Grafted Polyelectrolyte Microcapsules

Abstract: Polyelectrolyte microcapsules are fabricated by layer-by-layer deposition of dextran sulfate and poly-L -arginine layers at the surface of calcium carbonate template microparticles followed by core removal to produce hollow microcapsules. In the context of vaccination, these biodegradable LbL capsules emerge as promising antigen carriers and are believed to have potential for the co-delivery of antigens and immunomodulators associated within the same particle to enhance and steer the type of immune response. T… Show more

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Cited by 11 publications
(7 citation statements)
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References 33 publications
(40 reference statements)
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“…The capsules were formed by coating of liposome–AuC assemblies with polymer and lipid following an LBL fashion. , The liposome–AuC assembly was prepared by adding excess AuC to freshly prepared liposome solution followed by incubation for nearly 12 hours.…”
Section: Methodsmentioning
confidence: 99%
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“…The capsules were formed by coating of liposome–AuC assemblies with polymer and lipid following an LBL fashion. , The liposome–AuC assembly was prepared by adding excess AuC to freshly prepared liposome solution followed by incubation for nearly 12 hours.…”
Section: Methodsmentioning
confidence: 99%
“…For the lipid-coated layer, the polymercoated system (i.e., liposome−AuC−P) solution was incubated with the negatively charged liposomes (DMPC:DMPG, prepared in a ratio of 8:2) for 30 min above the phase transition temperature of the negatively charged liposome. 70 The coating conditions for each formulation were optimized beforehand. The optimal AuC, polymer, or lipid to capsule ratio was obtained experimentally by zeta potential values as obtained by titration of the respective capsules upon gradual addition of the polymer or lipid, respectively.…”
Section: ■ Introductionmentioning
confidence: 99%
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“…Although the LbL platform is still in its infancy and the data regarding the delivery of genetic material in vivo are limited, some important results were already demonstrated in preclinical studies of other LbL particles, which were stable in biological fluids and improved the pharmacokinetic profiles of the therapeutics as well as enhanced the safety and circulation halflife of the drug in vivo, proving a high clinical relevance of the platform [155,156]. By varying the particle diameter, and the charge and thickness of the LbL capsule wall, the distribution of the carriers in vivo may be tuned with control over the cargo release rate, depending on the specific aims [32].…”
Section: In Vivo Gene Therapymentioning
confidence: 99%
“…This system was modifi ed with immunopotentiators to further activate DCs. Thus, a pulmonary adaptive immune response was stimulated, which was characterized by induction of a strong Th17-polarized response (De Koker et al 2009b ;De Temmerman et al 2012 ). PMA SH /PVPON polyelectrolyte capsules, which are controllable in their size and peptide vaccine loading, were designed to disintegrate and release the peptide vaccine by rupture of disulfi de linkages upon exposure to reductive conditions.…”
Section: Micro-and Nanocapsulesmentioning
confidence: 99%