Modulation of conditioned taste aversion by sodium pentobarbital

Concannon, James T.; Freda, Jon S.

doi:10.1016/0091-3057(80)90203-8

Cited by 7 publications

(6 citation statements)

References 10 publications

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“…However, pentobarbital, which possesses anxiolytic-like activity in other test, did not alter the AI in the first two bottle tests when administered before a sucrose-LiCl conditioning trial in rats (Concannon and Freda 1980). This resembles the effect of benzodiazepines observed here.…”

Section: Discussionsupporting

confidence: 76%

Selective effects of benzodiazepines on the acquisition of conditioned taste aversion compared to attenuation of neophobia in C57BL/6 mice

2009

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Pre-conditioning administration of chlordiazepoxide (CDZ; 6-24 mg x kg(-1), i.p.) and alprazolam (0.3-1 mg x kg(-1), p.o.) resulted in a CTA that did not differ initially from that observed in vehicle-treated controls, but which showed faster extinction. The acquisition of AN was impaired only after the higher doses of CDZ (12-24 mg x kg(-1), i.p.) or alprazolam (1 mg x kg(-1), i.p.). The results show that in this test, altered acquisition of an aversive CTA memory by anxiolytic benzodiazepines is reflected in more rapid extinction. Moreover, at low doses, these drugs showed selectivity for weakening CTA learning compared to AN learning. Evidence is discussed that selective weakening of aversive memory formation is a clinically relevant effect of anxiolytic benzodiazepines.

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Section: Discussionsupporting

confidence: 76%

Selective effects of benzodiazepines on the acquisition of conditioned taste aversion compared to attenuation of neophobia in C57BL/6 mice

2009

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“…Previous research has also shown that sedativehypnotics attenuate the suppression of consummatory responses by amphetamine-paired stimuli (e.g., Cappell & LeBlanc, 1973;Concannon & Freda, 1980;Riley & Lovely, 1978). However, when drug-paired stimuli have main-tained responding, d-amphetamine can increase that behavior (e.g., Katz, 1980).…”

Section: Discussionmentioning

confidence: 99%

“…Both pentobarbital and chlordiazepoxide have previously been shown to attenuate conditioned taste aversions produced by d-amphetamine (Cappell & LeBlanc, 1973;Concannon & Freda, 1980;Riley & Lovely, 1978). Interestingly, these drugs also increase responding suppressed by the response-dependent (Geller & Seifter, 1960;Goldberg, 1980;Spealman, 1979;Valentine & Barrett, 1981) and response-independent (Miczek, 1973) delivery of a wide variety of stimuli.…”

Section: Methodsmentioning

confidence: 99%

RESPONSE SUPPRESSION BY VISUAL STIMULI PAIRED WITH POSTSESSION d‐AMPHETAMINE INJECTIONS IN THE PIGEON

Glowa

Barrett

1983

J Exper Analysis Behavior

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Responding of pigeons, maintained under a fixed-interval 3-minute schedule of food presentation, was decreased on days that the color of the lights illuminating the food magazine was changed and d-amphetamine (1.0 mg/kg, i.m.) was injected after the session. Responding was not decreased by keylight color changes paired with postsession d-amphetamine or by postsession injections of saline. Administration of pentobarbital (3.0 to 5.6 mg/kg), but not d-amphetamine (.3 to 3.0 mg/kg), before the session increased rates of responding suppressed by drug-paired magazine lights. Responding maintained under a fixed-ratio 30-response schedule was not decreased when differently colored magazine lights were paired vith a low (.3 mg/kg) postsession dose of d-amphetamine; with high (3.0 mg/kg) postsession doses, however, responding was completely suppressed after two pairings. The effects of pairing magazine stimuli with an intermediate (1.0 mg/kg) postsession dose of d-amphetamine depended upon the magnitude of prior postsession doses. After being paired with a low dose, stimuli paired with 1.0 mg/kg did not suppress responding. After being paired with a high dose, stimuli paired with 1.0 mg/kg completely suppressed responding. The suppression of food-maintained responding by stimuli paired with postsession drug administration depends upon both behavioral and pharmacological variables.

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“…On the other hand, pentobarbital has pronounced anxiolytic effects at the dose range used in this study (Concannon & Freda. 1979;Miczek & Luttinger, 1978).…”

Section: Discussionmentioning

confidence: 82%

“…Although controversial, it has been shown that under certain particular conditions, muscimol may have anxiolytic properties (Graeff, Brandao, Audi, & Schutz, 1986). Low doses of pentobarbital, however, consistently produce antianxiety effects (Concannon & Freda, 1979; Miczek & Luttinger, 1978). In addition, some evidence supports the idea that the GABAergic system may be involved in the internal time arrangement of copulation (Fernández-Guasti, Larsson, & Beyer, 1986), and it has been hypothesized that the reduction in the number of intromissions during EIC could be due to a disruption in such timing (H˙ard & Larsson, 1970).…”

Section: Experiments 2: Effect Of Gabaergic Drugsmentioning

confidence: 99%

Anxiolytics reverse the acceleration of ejaculation resulting from enforced intercopulatory intervals in rats.

Fernández‐Guasti¹,

Roldán-Roldán²,

Larsson³

1991

Behavioral Neuroscience

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The enforced interval of copulation (EIC) consists of the artificial prolongation of the interintromission interval, induces a reduction in the number of intromissions preceding ejaculation, and is accompanied by an anxiety like behavioral repertoire. The administration of the benzodiazepine anxiolytics diazepam, chlordiazepoxide, flurazepam, and flunitrazepam produced a dose-dependent inhibition of the EIC effect with a concomitant increase in mounting. These actions were blocked by the central benzodiazepine antagonist Ro 15-1788. The anxiogenic agent beta-carboline Zk 39106 had no effect. Treatment with pentobarbital also produced a blockade of the reduction in the number of intromissions during EIC, whereas muscimol and bicuculline lacked this effect. The serotonergic anxiolytic buspirone reversed the facilitatory action induced by EIC; however, two putative serotonergic antianxiety agents, 8-OH-DPAT and ipsapirone, did not modify or potentiate it, respectively. Finally, the nonanxiolytic serotonergic compounds 5-hydroxytryptophan and TFMPP drastically increased the number of mounts but did not antagonize the reduction of intromissions produced by EIC. These results suggest that an increase in the anxiety levels may be responsible for the excitatory action of EIC on sexual behavior.

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Modulation of conditioned taste aversion by sodium pentobarbital

Cited by 7 publications

References 10 publications

Selective effects of benzodiazepines on the acquisition of conditioned taste aversion compared to attenuation of neophobia in C57BL/6 mice

Selective effects of benzodiazepines on the acquisition of conditioned taste aversion compared to attenuation of neophobia in C57BL/6 mice

RESPONSE SUPPRESSION BY VISUAL STIMULI PAIRED WITH POSTSESSION d‐AMPHETAMINE INJECTIONS IN THE PIGEON

Anxiolytics reverse the acceleration of ejaculation resulting from enforced intercopulatory intervals in rats.

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