Modulation of cognitive cerebello-cerebral functional connectivity by lateral cerebellar continuous theta burst stimulation

Rastogi, Anuj; Cash, Robin; Dunlop, Katharine; Vesia, Michael; Kucyi, Aaron; Ghahremani, Ayda; Downar, Jonathan; Chen, Joyce; Chen, Robert

doi:10.1016/j.neuroimage.2017.06.048

Cited by 79 publications

(80 citation statements)

References 82 publications

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“…Complementing extensive findings linking VS and (more prominently) amygdala activation to negative affect , our results suggest that increased VS activation and decreased VS‐amygdala connectivity are associated with an attenuated negative emotional experience. Alternatively, as the VS is strongly associated with reward processing , these findings may reflect an altered balance between the generation of positive and negative valence, contributing to a change in net subjective emotional experience.…”

Section: Discussionsupporting

confidence: 82%

“…Modulated VS activity and VS‐amygdala connectivity may have also contributed to the influence on subjective emotional experience. Considered key structures in a core limbic system, both VS and amygdala are reliably activated in studies of negative and positive emotion, although their specific role in emotional experience is not yet clear . Complementing extensive findings linking VS and (more prominently) amygdala activation to negative affect , our results suggest that increased VS activation and decreased VS‐amygdala connectivity are associated with an attenuated negative emotional experience.…”

Section: Discussionsupporting

confidence: 71%

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Modulating Emotional Experience Using Electrical Stimulation of the Medial-Prefrontal Cortex: A Preliminary tDCS-fMRI Study

Abend

Sar-el

Gonen

et al. 2019

Neuromodulation: Technology at the Neural Interface

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Section: Discussionsupporting

confidence: 82%

Section: Discussionsupporting

confidence: 71%

Modulating Emotional Experience Using Electrical Stimulation of the Medial-Prefrontal Cortex: A Preliminary tDCS-fMRI Study

Abend

Sar-el

Gonen

et al. 2019

Neuromodulation: Technology at the Neural Interface

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“…Alternatively, iTBS was indeed eliciting network-wide effects as has been shown previously (He et al, 2013;Hoy et al, 2016;Rastogi et al, 2017), but the neurophysiological effects were sampled from only one hub (DLPFC) of the frontoparietal working memory network. It is possible that only one hub of the working memory network was modulated, while robust behavioural effects might require modulation of both frontal and parietal hubs of the fronto-parietal working memory network.…”

Section: Relationship Between Neurophysiological Changes and The Chmentioning

confidence: 97%

The effects of individualised intermittent theta burst stimulation in the prefrontal cortex: A TMS‐EEG study

Chung

Sullivan

Rogasch

et al. 2018

Human Brain Mapping

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Recent studies have highlighted variability in response to theta burst stimulation (TBS) in humans. TBS paradigm was originally developed in rodents to mimic gamma bursts coupled with theta rhythms, and was shown to elicit long‐term potentiation. The protocol was subsequently adapted for humans using standardised frequencies of stimulation. However, each individual has different rhythmic firing pattern. The present study sought to explore whether individualised intermittent TBS (Ind iTBS) could outperform the effects of two other iTBS variants. Twenty healthy volunteers received iTBS over left prefrontal cortex using 30 Hz at 6 Hz, 50 Hz at 5 Hz, or individualised frequency in separate sessions. Ind iTBS was determined using theta‐gamma coupling during the 3‐back task. Concurrent use of transcranial magnetic stimulation and electroencephalography (TMS‐EEG) was used to track changes in cortical plasticity. We also utilised mood ratings using a visual analogue scale and assessed working memory via the 3‐back task before and after stimulation. No group‐level effect was observed following either 30 or 50 Hz iTBS in TMS‐EEG. Ind iTBS significantly increased the amplitude of the TMS‐evoked P60, and decreased N100 and P200 amplitudes. A significant positive correlation between neurophysiological change and change in mood rating was also observed. Improved accuracy in the 3‐back task was observed following both 50 Hz and Ind iTBS conditions. These findings highlight the critical importance of frequency in the parameter space of iTBS. Tailored stimulation parameters appear more efficacious than standard paradigms in neurophysiological and mood changes. This novel approach presents a promising option and benefits may extend to clinical applications.

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“…Targeting the midline cerebellum, which is not part of the DMN, increased FC of the dorsal attention network [62]. Rastogi et al [63] found reduced FC in frontal and parietal cognitive regions after cTBS of the crus I of the lateral cerebellum. These results confirm the modulatory effect of cerebellar stimulation on large-scale cognitive networks and the opposite effect of excitatory and inhibitory TBS on connectivity.…”

Section: Local and Distal Connectivity Effects Of Nibsmentioning

confidence: 99%

Non-Invasive Brain Stimulation in Dementia: A Complex Network Story

et al. 2018

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Non-invasive brain stimulation (NIBS) is emerging as a promising rehabilitation tool for a number of neurodegenerative diseases. However, the therapeutic mechanisms of NIBS are not completely understood. In this review, we will summarize NIBS results in the context of brain imaging studies of functional connectivity and metabolites to gain insight into the possible mechanisms underlying recovery. We will briefly discuss how the clinical manifestations of common neurodegenerative disorders may be related with aberrant connectivity within large-scale neural networks. We will then focus on recent studies combining resting-state functional magnetic resonance imaging with NIBS to delineate how stimulation of different brain regions induce complex network modifications, both at the local and distal level. Moreover, we will review studies combining magnetic resonance spectroscopy and NIBS to investigate how microscale changes are related to modifications of large-scale networks. Finally, we will re-examine previous NIBS studies in dementia in light of this network perspective. A better understanding of NIBS impact on the functionality of large-scale brain networks may be useful to design beneficial treatments for neurodegenerative disorders.

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Modulation of cognitive cerebello-cerebral functional connectivity by lateral cerebellar continuous theta burst stimulation

Cited by 79 publications

References 82 publications

Modulating Emotional Experience Using Electrical Stimulation of the Medial-Prefrontal Cortex: A Preliminary tDCS-fMRI Study

Modulating Emotional Experience Using Electrical Stimulation of the Medial-Prefrontal Cortex: A Preliminary tDCS-fMRI Study

The effects of individualised intermittent theta burst stimulation in the prefrontal cortex: A TMS‐EEG study

Non-Invasive Brain Stimulation in Dementia: A Complex Network Story

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