Modulation of calcium oxalate dihydrate growth by phosphorylated osteopontin peptides

Chien, Yung Ching; Mansouri, Ahmad; Jiang, Wenge; Khan, Saeed R.; Gray, Jeffrey J.; McKee, Marc D.

doi:10.1016/j.jsb.2018.07.010

Cited by 19 publications

(21 citation statements)

References 88 publications

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“…9,[39][40][41] The control solutions (without peptide) showed the formation of well-facetted COM, which has a growth habit of layered-platelet structures caused by penetrating twinning of {001} and {100} faces. 12,42 However, the presence of CAP-pip in LIC, induced dramatic morphological changes on COM, showing smaller and fused crystals with disruptions in {100} face. At high magnification, these crystals exhibit steps and pits in their {121} faces.…”

Section: Effects Of Cap-pi and Cap-pip On Calcium Oxalate Crystallimentioning

confidence: 99%

“…high net-negative charge most effectively inhibit the formation of calcium oxalate monohydrate (COM) crystals. 2,8,12 Diverse studies suggest that phosphorylated proteins and/or peptides rich in aspartic acid, glutamic acid, and phosphoserine residues may reduce stone recurrence rates, because calcium-phosphate mineralization is blocked by the addition of phosphorylated peptides. 12,[17][18][19] One of the possible mechanisms by which proteins/peptides inhibit crystal mineralization is due to their strong capacity to be adsorbed on a face-specific fashion.…”

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confidence: 99%

“…2,8,12 Diverse studies suggest that phosphorylated proteins and/or peptides rich in aspartic acid, glutamic acid, and phosphoserine residues may reduce stone recurrence rates, because calcium-phosphate mineralization is blocked by the addition of phosphorylated peptides. 12,[17][18][19] One of the possible mechanisms by which proteins/peptides inhibit crystal mineralization is due to their strong capacity to be adsorbed on a face-specific fashion. 9,14,18,19 Cementum is a mineralized connective tissue that covers the roots of teeth and possesses unique characteristics.…”

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confidence: 99%

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Nucleation and growth inhibition of biological minerals by cementum attachment protein‐derived peptide (CAP‐pi)

Montoya

López

Arenas

et al. 2020

Journal of Peptide Science

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Biomineralization is a highly regulated process where proteins/peptides-crystal interactions contribute to the shaping, phasing and aggregation of minerals. We have identified and synthesized a cementum attachment protein-derived peptide (CAP-pi), which corresponds to amino acids 40-53 of the N-terminal CAP domain (MASSDEDGTNGGAS) and its phosphorylated variant (MASpSpDEDGTNGGASp) (CAP-pip). The peptide is composed of polar and negatively charged amino acids, which are disordered, according to in silico analysis. Our results show that CAP-pi inhibits hydroxyapatite (HA) formation and growth. However, it possesses low capacity to inhibit calcium oxalate crystal growth. CAP-pip showed a stronger inhibitory effect on the formation and growth of HA. As well as a high capacity to inhibit calcium oxalate monohydrate growth, mainly due to adsorption on specific growth faces. Small peptides have many advantages over the full-size protein, including lowcost production and modulation characteristics that allow for structural changes. Our findings suggest that CAP-pip-derived peptide could possess therapeutic potential to prevent or treat pathological calcifications such as renal stones and vascular calcification.

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Section: Effects Of Cap-pi and Cap-pip On Calcium Oxalate Crystallimentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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Nucleation and growth inhibition of biological minerals by cementum attachment protein‐derived peptide (CAP‐pi)

Montoya

López

Arenas

et al. 2020

Journal of Peptide Science

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“…Secretory protein SPP1 was involved in extracellular matrix binding of MF. Spp1, also known as osteopontin (OPN), is a significant component of the calcium oxalate crystal matrix and plays a vital role in modulating stone formation [27][28][29]; however, its role in the formation in kidney stones remains controversial. Some researchers found OPN to be a powerful synergistic inhibitor of renal calcinosis and stone formation [30,31].…”

Section: Biomed Research Internationalmentioning

confidence: 99%

iTRAQ-Based Comparative Proteomics Analysis of Urolithiasis Rats Induced by Ethylene Glycol

Cao

Duan

Gao

et al. 2020

BioMed Research International

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Nephrolithiasis is a frequent chronic urological condition with a high prevalence and recurrence rate. Proteomics studies on urolithiasis rat models are highly important in characterizing the pathophysiology of kidney stones and identifying potential approaches for preventing and treating kidney stones. The isobaric tags for relative and absolute quantification (iTRAQ) were performed to identify differentially expressed proteins (DEPs) in the kidney between urolithiasis rats and control rats. The results showed that 127 DEPs (85 upregulated and 42 downregulated) were identified in urolithiasis and control rats. The functions of DEPs were predicted by Gene Ontology (GO) analysis, Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis, and protein–protein interaction (PPI) network analysis. The expression of four upregulated proteins (Tagln, Akr1c9, Spp1, and Fbn1) and four downregulated proteins (Hbb, Epb42, Hmgcs2, and Ca1) were validated by parallel reaction monitoring (PRM). Proteomics studies of ethylene glycol-induced urolithiasis rat models using iTRAQ and PRM helped to elucidate the molecular mechanism governing nephrolithiasis and to identify candidate proteins for the treatment of kidney stones.

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“…As a result, it has the effect of initiating stone formation in the urinary area and kidney. Therefore, the number of studies on the inhibition of calcium oxalate monohydrate crystals has been increasing in recent years [20][21][22]. Although there are important advances in the pathophysiology and treatment of kidney stones, it is highly likely that kidney stones may occur again.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant, Enzyme Inhibitory and Calcium Oxalate Anti-crystallization Activities of Equisetum telmateia Ehrn.

Taşkın

Yilmaz

Doğan

2020

International Journal of Secondary Metabolite

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Equisetum L. is the only genus of the Equisetaceae family, which commonly known as horsetails, in English and atkuyruğu or kırkkilit in Turkish. In traditional medicine, Equisetum telmateia Ehrh. is used in diseases of the urinary system, such as pyelonephritis, prostatic hypertrophy, and cystitis. Besides, this species is known to be used by humans to treat kidney stones or kidney sand. The extracts were obtained from the aerial parts of the E. telmateia using three different extraction methods (maceration, Soxhlet, ultrasonic bath) and their antioxidant (ABTS, CUPRAC), anti-urease and anticholinesterase activities were examined. Also, calcium oxalate anticrystallization activity of Soxhlet methanol extract showing strong antioxidant activity was determined. Soxhlet methanol extract exhibited stronger ABTS radical scavenging (0.0676 mM Trolox/mg extract) and cupric ion reducing/antioxidant (4.351 mM Trolox/mg extract) activity than other extracts. Soxhlet methanol (65.528%) and maceration methanol (61.965%) extracts showed the strongest anticholinesterase activity. In the anti-urease assay, it was found that Soxhlet petroleum ether extract (15.302%) had the highest anti-urease activity. Furthermore, the data obtained showed that the Soxhlet methanol extract had high efficacy in the nucleation and aggregation phase of calcium oxalate crystals. These results prove that Soxhlet methanol extract has antioxidant, anticholinesterase and anti-crystallization capabilities. Therefore, this extract can be used in the future as an antioxidant and anticholinesterase agent as well as the treatment and / or prevention of stone formation.

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Modulation of calcium oxalate dihydrate growth by phosphorylated osteopontin peptides

Cited by 19 publications

References 88 publications

Nucleation and growth inhibition of biological minerals by cementum attachment protein‐derived peptide (CAP‐pi)

Nucleation and growth inhibition of biological minerals by cementum attachment protein‐derived peptide (CAP‐pi)

iTRAQ-Based Comparative Proteomics Analysis of Urolithiasis Rats Induced by Ethylene Glycol

Antioxidant, Enzyme Inhibitory and Calcium Oxalate Anti-crystallization Activities of Equisetum telmateia Ehrn.

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