Modulation of baseline behavior in rats by putative serotonergic agents in three ethoexperimental paradigms

Devi, Kshama; Hrishikeshavan, H. J.; Shanbhogue, Ravindranath; Munonyedi, Uba S.

doi:10.1016/0163-1047(90)90617-f

Cited by 60 publications

(35 citation statements)

References 28 publications

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“…Specifically, the evidence of the effect of fluoxetine on animal models of anxiety is controversial, and studies on its chronic effects are scarce. Acute fluoxetine has been shown to promote anxiogenic-like effects in rats tested in the elevated plus-maze (20)(21)(22), in the hole-board (20), and in a light-aversion test (20). The same effects are observed in the noveltysuppressed feeding model of anxiety (23) and in the antipredator defensive behavior of mice (24).…”

Section: Introductionsupporting

confidence: 57%

“…Simultaneously it decreased locomotor activity, as indicated by a reduction in the total number of arm entries and the number of closed arm entries. This motor activity reduction by fluoxetine has been observed before (20,33). The anxiogenic-like effect in the plus-maze has also been reported (20)(21)(22), but only after acute administration of the drug.…”

Section: Discussionmentioning

confidence: 68%

“…This motor activity reduction by fluoxetine has been observed before (20,33). The anxiogenic-like effect in the plus-maze has also been reported (20)(21)(22), but only after acute administration of the drug. In the present experiment both the chronic and the acute regimen of administration resulted in an anxiogenic profile.…”

Section: Discussionmentioning

confidence: 68%

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Anxiogenic-like effect of acute and chronic fluoxetine on rats tested on the elevated plus-maze

Silva

Alves

Santarem

1999

Braz J Med Biol Res

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The selective serotonin reuptake inhibitor fluoxetine (FLX) is widely prescribed for depression and anxiety-related disorders. On the other hand, enhanced serotonergic transmission is known to be classically related to anxiety. In this study, the effects of acute (5.0 mg/kg) and chronic (5.0 mg/kg, 22 days) FLX were investigated in both fooddeprived and non-deprived rats tested in the elevated plus-maze. Significant main effects of the three factors (drug, food condition and administration regimen) were observed, but no interaction between them. The administration of either acute or chronic FLX resulted in an anxiogenic effect, as detected by a significant reduction in the percentage of time spent in the open arms and in the percentage of open arm entries. Food deprivation yielded an anxiolytic-like profile, probably related to changes in locomotor activity. The administration regimen resulted in an anxiolytic profile in chronically treated rats, as would be expected after 22 days of regular handling. The anxiogenic action of acute FLX is consistent with both its neurochemical and clinical profile. The discrepancy between the anxiogenic profile of chronic FLX and its therapeutic uses is discussed in terms of possible differences between the type of anxiety that is measured in the plus-maze and the types of human anxiety that are alleviated by fluoxetine.

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Section: Introductionsupporting

confidence: 57%

Section: Discussionmentioning

confidence: 68%

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Anxiogenic-like effect of acute and chronic fluoxetine on rats tested on the elevated plus-maze

Silva

Alves

Santarem

1999

Braz J Med Biol Res

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“…Serotonin 2C (5-hydroxytryptamine, 5-HT 2C ) receptor activation, either by nonselective 5-HT 2C agonists such as m-chlorophenylpiperazine (m-CPP) and trifluoromethylphenylpiperazine (TFMPP) or the preferential 5-HT 2C agonist 6-chloro-2[1-piperazinyl]pyrazine (MK-212), has long been associated with anxiogenic-like profiles in a variety of animal models of anxiety, including the elevated plus-maze (EPM; Benjamin, Lal, & Meyerson, 1990;Kshama, Hrishikeshavan, Shanbhogue, & Munonyedi, 1990;Rodgers et al, 1992;Gibson et al, 1994;Griebel, Moreau, Jenck, Mutel, Martin, & Misslin, 1994;Fone, Shalders, Fox, Arthur, & Marsden, 1996;Wallis and Lal, 1998;Setem, Pinheiro, Motta, Morato, & Cruz, 1999;Jones, Duxon, & King, 2002;Bull, Huston, & Fone , 2003;Durand, Mormèd, & Chaouloff, 2003). In fact, newly selective 5-HT 2C agonists (e.g.…”

Section: Introductionmentioning

confidence: 99%

Effects of two selective 5-HT2C receptor-acting compounds into the ventral hippocampus of rats exposed to the elevated plus-maze.

Scarpelli¹,

Alves²,

Landeira-Fernández³

et al. 2008

Psychology & Neuroscience

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“…Anxiolytics drugs increases the proportion of entries, time spent and head dips. Imaizumi et al(1994) (Dunn et al, 1989;Kshama et al, 1990;Lee et al, 1991) noneffective (Moulton et al, 1990) anxiogenic (Pellow et al, 1987;Moser, 1989;Klint, 1991;Critcheley et al, 1992). A drug may have both anxiolytic and anxiogenic activities and either of the activites may be dependent on experimental conditions (Handley and Mcblane, 1993).…”

Section: Discussionmentioning

confidence: 99%

Effect of a polyherbal formulation on anxiety and behaviour mediated via monoamine neurotransmitters

Balaraman¹,

Mohan²,

Aurangabadkar³

et al. 2007

Oriental Pharmacy and Experimental Medicine

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SUMMARYWe investigated the effect of Arogh, a polyherbal formulation (PHF) on animal models of anxiety based on exploratory behavior. The anxiolytic activity of polyherbal formulation (30, 100, 300 and 500 mg/kg) was studied using various behavioural paradigms such as elevated plus maze (EPM), light/dark apparatus (LDA), open field apparatus (OFA), hole board apparatus (HBA). Diazepam (1 mg/kg) was used as a standard anxiolytic drug. The effect of PHF (100 and 300 mg/kg) on serotonin, dopamine and noradrenaline mediated behaviour was studied by lithium induced head twitches in rats, haloperidol induced catalepsy in mice and clonidine induced hypothermia in rats respectively. In EPM, PHF (100, 300 and 500 mg/kg) significantly (P < 0.05) increased the time spent in open arms and the number of entries in open arms. In LDA, PHF (100, 300 and 500 mg/kg) significantly (P < 0.05) increased the time spent in lit zone. In OFA, PHF (100, 300 and 500 mg/kg) significantly (P < 0.05) increased the number of assisted rearing and the number of squares traversed. In HBA, PHF (100, 300 and 500 mg/kg) significantly (P < 0.05) increased the number of head poking. In lithium induced head twitches, PHF (100 and 300 mg/kg) significantly (P < 0.05) decreased the number of head twitches. In haloperidol induced catalepsy, PHF (300 mg/kg) decreased the duration of catalepsy significantly (P < 0.05) at 60 min. In clonidine-induced hypothermia, PHF (300 mg/kg) did not modify the effect. Drugs must be carefully assessed on EPM test and therefore in the present study EPM is supported by other tests. Present study indicates that Arogh, a polyherbal formulation possess anxiolytic activity. It diminished serotonergic transmission and decreased the duration of catalepsy indicating potentiation of dopaminergic transmission. Thus, Arogh a polyherbal formulation contains bioactive principles which possess anxiolytic activity and modified 5-HT and DA mediated behaviour.

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Modulation of baseline behavior in rats by putative serotonergic agents in three ethoexperimental paradigms

Cited by 60 publications

References 28 publications

Anxiogenic-like effect of acute and chronic fluoxetine on rats tested on the elevated plus-maze

Anxiogenic-like effect of acute and chronic fluoxetine on rats tested on the elevated plus-maze

Effects of two selective 5-HT2C receptor-acting compounds into the ventral hippocampus of rats exposed to the elevated plus-maze.

Effect of a polyherbal formulation on anxiety and behaviour mediated via monoamine neurotransmitters

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