Modulation of B Lymphocyte Differentiation by Calcitonin Gene-Related Peptide (CGRP)

McGillis, Joseph P.; Humphreys, S.C.; Rangnekar, Vidya; Ciallella, John R.

doi:10.1006/cimm.1993.1207

Cited by 39 publications

(11 citation statements)

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“…CGRP by itself did not stimulate colony production nor did it affect the response to IL-7 (data not shown). The weak potency of this antagonist is consistent with its ability to inhibit CGRP receptor binding and to block cAMP production [26,27,[37][38][39].…”

Section: Cgrp Inhibits Il-7-induced Formation Of Pre-b Cell Colonies mentioning

confidence: 73%

“…The immunomodulatory neuropeptide vasoactive intestinal peptide (VIP) has also been shown to inhibit B cell responses to IL-7 [25]. A potential role for CGRP in early B cell development is suggested by its ability to inhibit differentiation in the murine pre B cell line 70Z/3 [26]. In the 70Z/3 pre-B cell line, CGRP inhibits lipopolysaccharide-and IL-1␤-induced expression of surface immunoglobulin, an event that presumably occurs on normal cells subsequent to IL-7-induced expansion.…”

Section: Introductionmentioning

confidence: 99%

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Calcitonin-gene related peptide (CGRP) inhibits interleukin-7-induced pre-B cell colony formation

Fernandez

Knopf

McGillis

2000

Journal of Leukocyte Biology

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Calcitonin gene-related peptide (CGRP) is a sensory neuropeptide with inflammatory and immunoregulatory activities. Its role in B lymphocyte development was investigated using a pre-B cell colony-forming assay. Physiological concentrations of CGRP inhibited pre-B cell responses to interleukin-7 (IL-7). Inhibition was specific in that it was blocked by the CGRP antagonist CGRP 8-37 . Adrenomedulin, substance P, and calcitonin had no

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Section: Cgrp Inhibits Il-7-induced Formation Of Pre-b Cell Colonies mentioning

confidence: 73%

Section: Introductionmentioning

confidence: 99%

Calcitonin-gene related peptide (CGRP) inhibits interleukin-7-induced pre-B cell colony formation

Fernandez

Knopf

McGillis

2000

Journal of Leukocyte Biology

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“…First, CGRP inhibits IL-1-or LPS-induced expression of the BCR on the 70z/3 pre-B cell line [20]. The 70Z/3 pre-B cell line has been used to study cellular events in the transition from a BCR -pre-B cell phenotype to a BCR ϩ immature phenotype [25].…”

Section: Introductionmentioning

confidence: 99%

Calcitonin gene-related peptide inhibits early B cell development in vivo

Schlomer

Storey

Ciornei

et al. 2006

Journal of Leukocyte Biology

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Recent in vitro studies suggest that calcitonin gene-related peptide (CGRP) inhibits early B cell differentiation; however, there is no evidence in the intact animal for a role for CGRP in B cell development. Here, we show that in vivo treatment of mice with CGRP reduces the number of IL-7 responsive B cell progenitors in bone marrow. A single CGRP treatment reduces IL-7-responsive B cell progenitors by up to 40% for up to 72 h. The reduction is dose-dependent and can be blocked by a CGRP receptor antagonist, CGRP(8-37). CGRP in serum following injection is highly elevated at 30 min but returns to basal levels by 4 h, suggesting that a single injection of CGRP has long-lasting effects on B cell development. This report provides the first direct in vivo evidence that CGRP, a neuropeptide with multiple effects on mature lymphocytes, also plays a regulatory role in early B cell development in the bone marrow.

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“…In addition, the calcitonin gene-related peptide (CGRP), a neuropeptide, is involved in cutaneous inflammation following DYB irradiation (60). CGRP causes potent vasodilation (61) and also several immunomodulatory effects (62)(63)(64)(65)(66)(67)(68). CGRP inhibits antigen presentation by LC, contact hypersensitivity (CHS) and delayed-type hypersensitivity (DTH) (69)(70)(71), proliferation of T lymphocytes (62), activation of NK cells (66), and functions of macrophages (70)(71)(72)(73).…”

Section: Damageddna Urocanicacid and Cutaneous Nervous System Are Rmentioning

confidence: 99%

Dissociation of Innate and Adaptive Immunity by UVB Irradiation

Kasahara

Wago

2002

Int J Immunopathol Pharmacol

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Increasing ultraviolet-B irradiation (UVB) resulting from diminution of stratospheric ozone is becoming a serious international problem. UVB irradiation exerts not only carcinogenic effects on animals but also causes them to become vulnerable to infections by modulating their immune responses. UVB irradiation suppresses innate immune functions of cells such as macrophages, neutrophiIs, Langerhans cells, dendritic cells, and the serum component, complement. UVB irradiation also causes changes in cytokine profiles, represented by the induction of a paradigm switch involving Thl/Th2 phenotypes. According to earlier studies, Thl responses are suppressed, whereas Th2 activities are augmented by UVB irradiation. These immune modulations are caused by several pathways via cytokines and neuropeptides, and eventually may lead to increasing incidences of infection, allergy, and cancer. We have reviewed reports concerning UVB-irradiation induced immune modulation from the viewpoint of risks for human diseases and, in addition, for ecosystems and immunity of lower animals.

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Modulation of B Lymphocyte Differentiation by Calcitonin Gene-Related Peptide (CGRP)

Cited by 39 publications

References 0 publications

Calcitonin-gene related peptide (CGRP) inhibits interleukin-7-induced pre-B cell colony formation

Calcitonin-gene related peptide (CGRP) inhibits interleukin-7-induced pre-B cell colony formation

Calcitonin gene-related peptide inhibits early B cell development in vivo

Dissociation of Innate and Adaptive Immunity by UVB Irradiation

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