Modulation of Apolipoprotein D levels in human pregnancy and association with gestational weight gain

Carmo, Sonia Do; Forest, Jean‐Claude; Giguère, Yves; Masse, André; Lafond, Julie; Rassart, Éric

doi:10.1186/1477-7827-7-92

Cited by 19 publications

(20 citation statements)

References 55 publications

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“…Interestingly, plasma apolipoprotein returned to baseline after birth more quickly in lactating women compared to those who were not breastfeeding. 40 In our study, colostral apolipoprotein D abundance was higher in women with GDM versus in women without GDM. Liao et al showed that apolipoprotein D levels were higher in colostrum relative to mature milk.…”

Section: Discussionsupporting

confidence: 45%

The Human Colostrum Whey Proteome Is Altered in Gestational Diabetes Mellitus

Lemay¹,

Weber²,

Phinney³

et al. 2014

J. Proteome Res.

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Proteomics of human milk has been used to identify the comprehensive cargo of proteins involved in immune and cellular function. Very little is known about the effects of gestational diabetes mellitus (GDM) on lactation and breast milk components. The objective of the current study was to examine the effect of GDM on the expression of proteins in the whey fraction of human colostrum. Colostrum was collected from women who were diagnosed with (n = 6) or without (n = 12) GDM at weeks 24–28 in pregnancy. Colostral whey was analyzed for protein abundances using high-resolution, high-mass accuracy liquid chromatography tandem mass spectrometry. A total of 601 proteins were identified, of which 260 were quantified using label free spectral counting. Orthogonal partial least-squares discriminant analysis identified 27 proteins that best predict GDM. The power law global error model corrected for multiple testing was used to confirm that 10 of the 27 proteins were also statistically significantly different between women with versus without GDM. The identified changes in protein expression suggest that diabetes mellitus during pregnancy has consequences on human colostral proteins involved in immunity and nutrition.

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Section: Discussionsupporting

confidence: 45%

The Human Colostrum Whey Proteome Is Altered in Gestational Diabetes Mellitus

Lemay¹,

Weber²,

Phinney³

et al. 2014

J. Proteome Res.

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“…50–53 Excess GWG has also been associated with alterations in metabolic markers in the maternal serum. 54 We recently demonstrated that the placental microbiome and the bacterial encoded metabolic pathways significantly vary in association with preterm birth. 8 Notably, these findings were independent of mode of delivery, which means that there were no differences in the placental microbiome of vaginal deliveries compared with cesarean deliveries.…”

Section: Commentmentioning

confidence: 99%

“…However, excess gestational weight gain (GWG) has also been associated with increased risk of preterm birth 50–53 and alterations in metabolic markers. 54 Thus this begs the question, is it obesity or excess GWG that modulates the triad of inflammation, an altered placental microbiome, and spontaneous preterm birth?…”

mentioning

confidence: 99%

The preterm placental microbiome varies in association with excess maternal gestational weight gain

Antony

Mitchell

et al. 2015

American Journal of Obstetrics and Gynecology

187

181

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OBJECTIVE Although a higher maternal body mass index is associated with preterm birth, it is unclear whether excess gestational weight gain (GWG) or obesity drives increased risk. We and others have shown that the placenta harbors microbiota, which is significantly different among preterm births. Our aim in this study was to investigate whether the preterm placental microbiome varies by virtue of obesity or alternately by excess GWG. STUDY DESIGN Placentas (n = 320) were collected from term and preterm pregnancies. Genomic DNA was extracted and subjected to metagenomic sequencing. Data were analyzed by clinical covariates that included the 2009 Institute of Medicine’s GWG guideline and obesity. RESULTS Analysis of 16S recombinant RNA–based metagenomics revealed no clustering of the microbiome by virtue of obesity (P = .161). Among women who spontaneously delivered preterm, there was again no clustering by obesity (P = .480), but there was significant clustering by excess GWG (P = .022). Moreover, among pretermbirths, detailed analysis identified microbial genera (family and genus level) and bacterial metabolic gene pathways that varied among pregnancies with excess GWG. Notably, excess GWG was associated with decreased microbial folate biosynthesis pathways and decreased butanoate metabolism (linear discriminate analysis, >3.0-fold). CONCLUSION Although there were no significant alterations in the microbiome by virtue of obesity per se, excess GWG was associated with an altered microbiome and its metabolic profile among those women who experienced a preterm birth.

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“…Neither the role nor the physiological ligands of ApoD have been clearly identified, but many studies suggest that it is a multifunctional protein binding many ligands (cholesterol, progesterone, pregnenolone, bilirubin and arachidonic acid), several of which are relevant in the reproductive tract [23,24]. The multifunctional role of ApoD is reflected by the fact that it is differentially expressed during cellular growth and differentiation, cancer, nervous system pathologies, inflammation and oxidative stress [10,25] and is inversely correlated with proliferation of fibroblasts in a tissue-specific manner [26].…”

Section: Commentsmentioning

confidence: 99%