Modulation of adipocyte lipogenesis by octanoate: involvement of reactive oxygen species

Guo, Wen; Xie, Weisheng; Han, Jianrong

doi:10.1186/1743-7075-3-30

Cited by 37 publications

(25 citation statements)

References 74 publications

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“…Through multiple mechanisms, the n-6 PUFA may reduce SREBP-1c expression or functional protein (Yahagi et al 1999), decreasing the expression of both the FAS and SCD genes. It differs from a previous study suggesting that the MCFA can reduce lipogenic gene expression under in vitro conditions (Guo et al 2006). The SCD transcript concentration in the adipose tissue of CO fed pigs was not different from the animals fed on Control ration.…”

Section: Discussioncontrasting

confidence: 99%

“…One of the mechanisms by which n-6 PUFA exert their anti-lipogenic effect is by inhibiting the expression of sterol regulatory element binding protein-1c (SREBP-1c), a transcription factor belonging to basic helix-loop-helix leucine zipper family (Yahagi et al 1999). Limited reports suggest that medium-chain saturated fatty acids (MCFA) may also possess anti-lipogenic effect in the adipose tissue (Guo et al 2006).…”

Section: Introductionmentioning

confidence: 99%

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Effect of dietary sunflower oil and coconut oil on adipose tissue gene expression, fatty acid composition and serum lipid profile of grower pigs

Iyer

Sarmah

Tamuli

et al. 2012

Archives of Animal Nutrition

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The present study was conducted to assess whether the partial replacement of feed energy by vegetable oils containing high medium-chain saturated fatty acids (MCFA) and n-6 polyunsaturated fatty acids (PUFA) would modify lipogenic gene expression and other parameter of fat metabolism in pigs. Eighteen pigs (17-19 kg body weight) received one of three experimental diets for 60 days (six animals per group): (i) Control diet; (ii) a diet with sunflower oil (SO) or (iii) a diet with coconut oil (CO). In diets SO and CO, 10% of the feed energy was replaced by the respective oils. The experimental treatment did not influence the performance of the pigs. In blood serum, an increased content of total cholesterol was observed for SO and CO fed animals, whereas no significant changes for total triglycerides and different lipoprotein fractions were detected. The fatty acid composition of adipose tissue was significantly modified, with an increased content of MCFA and n-6 PUFA in CO and SO fed pigs, respectively. The gene expression for fatty acid synthase was decreased for SO and CO fed pigs; for stearoyl CoA desaturase and sterol regulatory element binding protein, a depression was observed in SO but not in CO fed pigs. The results of present study suggest that the type of dietary fat can modulate the adipose tissue gene expression and fatty acid composition differentially, with minimal effect on serum lipid profile.

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Section: Discussioncontrasting

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of dietary sunflower oil and coconut oil on adipose tissue gene expression, fatty acid composition and serum lipid profile of grower pigs

Iyer

Sarmah

Tamuli

et al. 2012

Archives of Animal Nutrition

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“…Our findings demonstrated that rosiglitazone dose dependently inhibited ROS production, suggesting that this is how it inhibited MC proliferation. Our results correspond to reports showing that PPAR␥ agonists suppress agent-induced ROS generation (21,27).…”

Section: Discussionsupporting

confidence: 92%

A PPARγ agonist inhibits aldosterone-induced mesangial cell proliferation by blocking ROS-dependent EGFR intracellular signaling

Yuan

Zhang

Huang

et al. 2011

American Journal of Physiology-Renal Physiology

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Mesangial cell (MC) proliferation is a key feature in the pathogenesis of a number of renal diseases. Peroxisome proliferator-activated receptor-␥ (PPAR␥) has attracted considerable attention for its effects on stimulating cell differentiation and on inducing cell cycle arrest. We previously showed that aldosterone (Aldo) stimulates MC proliferation via the phosphoinositide 3-kinase (PI3K)/Akt signaling pathway, which was dependent on reactive oxygen species (ROS)-mediated epithelial growth factor receptor (EGFR) transactivation (Huang S, Zhang A, Ding G, and Chen R. Am J Physiol Renal Physiol 296: F1323-F1333, 2009). In this study, we examined whether the PPAR␥ agonist rosiglitazone inhibited Aldo-induced MC proliferation by modulating ROS-dependent EGFR intracellular signaling. Rosiglitazone at 1-10 M dose dependently inhibited Aldo-induced MC proliferation of cultured mouse MCs. The inhibitory effect was blocked by the PPAR␥ antagonist PD-68235, indicating that the rosiglitazone effect acted through PPAR␥ activation. Rosiglitazone also arrested Aldo-induced cell cycle progression and suppressed expression of cyclins D1 and A. Moreover, rosiglitazone dose dependently blocked Aldo-induced ROS production, EGFR phosphorylation, and PI3K/Akt activation. These results suggest that the PPAR␥ agonist rosiglitazone may inhibit Aldo-induced MC proliferation directly, by affecting ROS/EGFR/ PI3K/Akt signaling pathways and cell cycle-regulatory proteins. PPAR␥ might be a novel therapeutic target against glomerular diseases.peroxisome proliferator-activated receptor-␥; glomerular disease MESANGIAL CELLS (MCs) are resident cells of the glomerulus that are important for maintaining structure and function. Abnormal growth of glomerular MCs is a predominant histological feature of several glomerular diseases, and growth regulation may influence the outcome of glomerulonephritis (13,30,37). Elucidating the mechanisms of MC proliferation may contribute to the development of effective treatment strategies for glomerular diseases. However, the stimulation of MC proliferation in response to glomerular injury has been attributed to multiple factors, hindering our understanding of the molecular basis of this process (23,24,28,43).Recently, attention has focused on the role of aldosterone (Aldo) in the development and progression of cardiovascular disease and chronic kidney disease (1,14,16,38). As an important mediator of the renin-angiotensin-aldosterone system, plasma and tissue Aldo are elevated in diabetic and other Address for reprint requests and other correspondence:

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“…Similar results were obtained by Kim et al [15] and Guo et al [16] following studies of the effects of PPAR-c agonists on phorbol ester-treated glioma and osteoblast cells. Thus, while calphostin C is a known inhibitor of PKC, it appears that the PPAR-c agonist rosiglitazone may modulate PKC and/or components of the NADPH-oxidase cascade.…”

Section: Discussionsupporting

confidence: 78%

Rosiglitazone, a PPAR-γ agonist, inhibits VEGF secretion by peripheral blood mononuclear cells and ROS production by human leukocytes

2011

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Modulation of adipocyte lipogenesis by octanoate: involvement of reactive oxygen species

Cited by 37 publications

References 74 publications

Effect of dietary sunflower oil and coconut oil on adipose tissue gene expression, fatty acid composition and serum lipid profile of grower pigs

Effect of dietary sunflower oil and coconut oil on adipose tissue gene expression, fatty acid composition and serum lipid profile of grower pigs

A PPARγ agonist inhibits aldosterone-induced mesangial cell proliferation by blocking ROS-dependent EGFR intracellular signaling

Rosiglitazone, a PPAR-γ agonist, inhibits VEGF secretion by peripheral blood mononuclear cells and ROS production by human leukocytes

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