Modulation of acute transient exercise-induced hypertension after oral administration of four angiotensin-converting enzyme inhibitors in normotensive horses

Muñoz, A.; Esgueva, María; Gómez-Díez, Manuel; Serrano-Caballero, J.M.; Castejón‐Riber, Cristina; Serrano-Rodríguez, Juan Manuel

doi:10.1016/j.tvjl.2015.10.036

Cited by 10 publications

(13 citation statements)

References 33 publications

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“…Studies in healthy horses which, as in our study, used FAPPG as substrate for analysis showed slightly higher values (Costa et al 2011, Afonso et al 2013, Munoz et al 2016 Our results agree with those of Costa et al (2016) (86 ± 18 U/L) and Afonso et al (2013) (59 ± 13.4 U/L). In contrast to that, Munoz et al (2016) showed slightly higher Fig. 1 Concentration of plasma concentration of the angiotensin-converting enzyme (ACE) directly prior (pre) and post three-month therapy in Group 1.…”

Section: Discussionsupporting

confidence: 92%

“…The reference values in humans are determined to vary between 13.3 and 63.9 U/L (Camos et al 2012). Studies in healthy horses which, as in our study, used FAPPG as substrate for analysis showed slightly higher values (Costa et al 2011, Afonso et al 2013, Munoz et al 2016 Our results agree with those of Costa et al (2016) (86 ± 18 U/L) and Afonso et al (2013) (59 ± 13.4 U/L). In contrast to that, Munoz et al (2016) showed slightly higher Fig.…”

Section: Discussionsupporting

confidence: 90%

“…Poor oral bioavailability of enalapril led to new studies of various alternative ACE inhibitors in the horse. The best efficacy, based on a lowering of the ACE plasma activity, has been proven for ramipril and benazepril in the horse (Afonso et al 2013, Munoz et al 2016. A slight increase in inhibition of the ACE activity can be shown by a dosage increase of 0.5 mg/kg to 2 mg/kg.…”

Section: Discussionmentioning

confidence: 99%

“…Effect of the ACE inhibitor enalapril on plasma ACE concentration in horses with left side heart valve insufficiency values (80 -120 U/L) (Costa et al 2011, Camos et al 2012, Munoz et al 2016).…”

Section: -mentioning

confidence: 99%

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Effect of the ACE inhibitor enalapril on plasma ACE concentration in horses with left side heart valve insufficiency

Gehlen¹,

Rapp²

2020

PHK

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Even though angiotensin-converting enzyme (ACE) inhibitors are often used in horses, only a few studies exist that investigate the effect of these drugs in horses suffering from heart disease. The aim of this work was to examine the effect of the ACE inhibitor enalapril on the plasma ACE concentration of horses diagnosed with a left-sided heart valve insufficiency. We hypothesize that the use of the ACE inhibitor enalapril leads to a lowered ACE concentration in the equine blood plasma of horses suffering from a left-side heart valve insufficiency. Therefor we evaluated twenty-five horses with aortic and/or mitral valve insufficiency. All animals received daily dose of enalapril per os (0.5 mg/ kg) over a period of three months. The horses were divided into two groups. Horses in Group 1 were examined immediately prior to the trials and after the three-month therapy period. Horses in Group 2 were examined a third time, three months prior to the start of treatment with enalapril. Serum ACE concentration was measured photometrically. No horse showed any signs of noticeable adverse effects. A statistically significant increase in ACE activity has been recorded in Group 1 and Group 2 under the therapy with enalapril (p = 0.00). While no treatment was performed on the horses in Group 2, no statistically significant difference in ACE activity could be shown (p = 0.00). The study showed an effect of the ACE inhibitor enalapril on the renin-angiotensin-aldosterone system in horses diagnosed with left-side heart valve insufficiency. However, our results contradicted expectations that enalapril would lead to a lowered ACE concentration in the equine blood plasma. Further studies on cardiac efficacy would be desirable.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: -mentioning

confidence: 99%

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Effect of the ACE inhibitor enalapril on plasma ACE concentration in horses with left side heart valve insufficiency

Gehlen¹,

Rapp²

2020

PHK

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“…Similarly, oral benazepril at the same dose was more effective at attenuating exercise-induced hypertension than enalapril, quinapril or ramipril [14]. More recently, oral benazepril at a dose of 1 mg/kg was superior to a dose of 0.5 mg/kg at attenuating the rise in blood pressure after administration of exogenous angiotensin I, whereas administration of higher dosages did not provide additional benefit [15].…”

Section: Introductionmentioning

confidence: 99%

Preliminary investigation of orally administered benazepril in horses with left‐sided valvular regurgitation

Afonso

Giguère

Brown

et al. 2017

Equine Veterinary Journal

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Treatment with oral benazepril resulted in statistically significant echocardiographic changes that might indicate reduced cardiac afterload in horses with left-sided valvular regurgitation. Additional studies with a larger sample size will be necessary to determine if administration of benazepril is beneficial in horses with valvular regurgitation. The Summary is available in Spanish - see Supporting Information.

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Disorders of the Cardiovascular System

Schwarzwald¹

2018

Equine Internal Medicine

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Modulation of acute transient exercise-induced hypertension after oral administration of four angiotensin-converting enzyme inhibitors in normotensive horses

Cited by 10 publications

References 33 publications

Effect of the ACE inhibitor enalapril on plasma ACE concentration in horses with left side heart valve insufficiency

Effect of the ACE inhibitor enalapril on plasma ACE concentration in horses with left side heart valve insufficiency

Preliminary investigation of orally administered benazepril in horses with left‐sided valvular regurgitation

Disorders of the Cardiovascular System

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