Modulation in Aggregation Behavior of Cationic Surfactant in Presence of Fluoroquinolone Drug: A Physicochemical Approach

Abstract

Measurements of density, speed of sound, conductivity, and fluorescence spectroscopy have been carried out to study the interactions between cationic surfactant cetyltrimethylammonium bromide in an aqueous solution of the fluoroquinolone drug at different concentrations and temperatures. Volumetric and compressibility parameters, such as apparent molar volumes (V φ ), isentropic compressibility (κ s ), and apparent molar isentropic compressibility (κ φ, s ), have been obtained from density and speed of sound. The critical micelle concentration (CMC) of cetyltrimethylammonium bromide (CTAB) is found to decrease with an increase in [antibiotic drug] and increase with an increase in temperature, accounting for the fact that hydrophilic dehydration plays a decisive role for micellization to take place. The various thermodynamic parameters indicate the spontaneity of micellization in the presence of drug moiety. The CMC values have been calculated using pyrene as a fluorescent probe at room temperature, and a good qualitative correlation is found to exist well with the CMC values determined using speed of sound and conductivity measurements.

Insight of molecular interactions between short‐chain tetraalkylammonium bromides and cetyltrimethylammonium bromide: A spectroscopic and thermodynamic approach

“…Figure 5 and Figures S8 and S9 show that, as alkyl chain length increases, the value decreases, indicating that the higher the value, the less stable micelles form. In addition, the value for compensation temperature, T c , falls within the well‐established 284–310 K temperature range for different alkyl ammonium bromide surfactants (Chauhan & Pathania, 2018; Pathania & Chauhan, 2020a, 2020b).…”

“…It has been found that the hydrophobes of tetraalkyl ammonium salt are known to penetrate into the micellar core of the surfactant and have a tendency to make the micelle shrink and act as spacers between the surfactant head groups (Esan et al, 2015). Apart from this, in molten state, these salts also behave as ionic liquids and in this capacity, various multiapproach applications concentrating on the change in the behavior of aqueous surfactant solution with the incorporation of additives like electrolytes or drugs have been published in recent years (Pathania & Chauhan, 2020b; Tanwar et al, 2021). Therefore, in the present work, the changes in the physicochemical properties of CTAB in aqueous solution upon addition of R 4 N + Br − at different temperatures have been investigated by using conductometric technique and calculating various thermodynamic parameters which are useful to know about the thermal stability of these ternary systems.…”

Aggregation and Adsorption Behavior of Cationic Surfactants (Cetyltrimethylammonium Bromide and Dodecyltrimethylammonium Bromide) in Aqueous Solutions of Antibiotic Drug (Amikacin Sulphate) at Different Temperatures

“…The spontaneity of process is portrayed analogous to sign of values. The negative values, divulges that the CTAB and DTAB molecules undergo spontaneous aggregation in aqueous solutions of amikacin sulphate (Pathania and Chauhan, 2020).…”