Modulation by gamithromycin and ketoprofen of in vitro and in vivo porcine lipopolysaccharide-induced inflammation

Wyns, Heidi; Meyer, Evelyne; Plessers, Elke; Watteyn, Anneleen; Bergen, Thomas van; Schauvliege, Stijn; Baere, Siegrid De; Devreese, Mathias; Backer, Patrick De; Croubels, Siska

doi:10.1016/j.vetimm.2015.09.014

Cited by 24 publications

(19 citation statements)

References 69 publications

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“…Several studies have shown that typical responses to LPS challenge in pigs are reduced feed intake, increase in body temperature (fever), strong increases in the concentrations of proinflammatory cytokines, APP and cortisol and reduction in the plasma concentration of insulin‐like growth factor (IGF)‐1. Reduced feed intake, increased energy requirement for the production of fever and hormonal changes shift the metabolism into a more catabolic state which results in reduced body weight gains and an impairment of the gain‐to‐feed ratio (Webel et al., ; Liu et al., ; Campos et al., ; Wyns et al., ). Increases of plasma non‐esterified fatty acids (NEFA) and urea concentrations after LPS challenge are indicative of an increased lipolysis in adipose tissue and an increased protein breakdown in muscle (Johnson, ).…”

Section: Consequences Of Inflammation On Performance Of Farm Animalsmentioning

confidence: 99%

Potential of plant polyphenols to combat oxidative stress and inflammatory processes in farm animals

Geßner

Ringseis

Eder

2016

Animal Physiology Nutrition

249

198

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Polyphenols are secondary plant metabolites which have been shown to exert antioxidative and antiinflamma tory effects in cell culture, rodent and human studies. Based on the fact that conditions of oxidative stress and inflammation are highly relevant in farm animals, polyphenols are considered as promising feed additives in the nutrition of farm animals. However, in contrast to many studies existing with model animals and humans, potential antioxidative and antiinflammatory effects of polyphenols have been less investigated in farm animals so far. This review aims to give an overview about potential antioxidative and antiinflammatory effects in farm animals. The first part of the review highlights the occurrence and the consequences of oxidative stress and inflammation on animal health and performance. The second part of the review deals with bioavailability and metabolism of polyphenols in farm animals. The third and main part of the review presents an overview of the findings from studies which investigated the effects of polyphenols of various plant sources in pigs, poultry and cattle, with particular consideration of effects on the antioxidant system and inflammation.

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Section: Consequences Of Inflammation On Performance Of Farm Animalsmentioning

confidence: 99%

Potential of plant polyphenols to combat oxidative stress and inflammatory processes in farm animals

Geßner

Ringseis

Eder

2016

Animal Physiology Nutrition

249

198

View full text Add to dashboard Cite

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“…of LPS (Wright et al, 2000;Peters et al, 2012;Wyns et al, 2015). The porcine febrile response commonly peaks at approximately 4 h p.a.…”

Section: Prostaglandin E 2 and The Febrile Responsementioning

confidence: 99%

“…Although these methods are sensitive, they are not very specific. The development of cost-effective analytical methods for the detection and quantification of multiple prostaglandins and thromboxanes by liquid chromatography-tandem mass spectrometry (LC-MS/MS) is therefore of growing interest (Araujo et al, 2013;Wyns et al, 2015).…”

Section: Thromboxane B 2 and Pulmonary Hypertensionmentioning

confidence: 99%

In vivo porcine lipopolysaccharide inflammation models to study immunomodulation of drugs

Wyns

Plessers

Backer

et al. 2015

Veterinary Immunology and Immunopathology

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“…De gevoeligheid voor LPS verschilt eveneens tussen zoogdieren en vogels. Zo is er een veel hogere dosis LPS nodig om een ontstekingsreactie op te wekken bij kippen (1 mg/kg lichaamsgewicht of LG) dan bij kalveren (0,5 μg/kg LG) en varkens (15 µg/kg LG) (De Boever et al, 2008;Wyns et al, 2014;Plessers et al, 2015). Deze verschillen zijn onder andere het gevolg van een mobiliteitsverschil van CD14, waarbij dit eiwit minder mobiel is in de celmembraan van kippen dan in die van zoogdieren.…”

Section: Conclusieunclassified

Pathofysiologie van lipopolysaccharide geïnduceerde inflammatoire respons bij vogels

Houben¹,

Croubels²,

Watteyn³

et al. 2017

Vlaams Diergeneeskundig Tijdschrift

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Inflammatie is een beschermende respons op infectie en/of weefselschade die gepaard gaat met de migratie van immuuncellen en mediatoren van de circulatie naar het betreffende weefsel. Deze respons dient om de initiële noxe (onder andere lipopolysaccharide of LPS) te verwijderen en genezing en herstel van het beschadigde weefsel te bekomen. LPS is een onderdeel van de buitenste celmembraan van gramnegatieve bacteriën dat pro-inflammatoire eigenschappen heeft en na toediening bij vogels een ontstekingsreactie teweegbrengt. Deze ontstekingsreactie gaat gepaard met onder andere veranderingen in lichaamstemperatuur, de productie van pro-inflammatoire cytokinen en vorming van acutefase-eiwitten, leukocytose en ziektegedrag. In welke mate elk van deze symptomen aanwezig is bij vogels hangt af van de vogelsoort. Bovendien zijn er verschillen met zoogdieren. De karakteristieken en pathofysiologische gevolgen van een ontstekingsreactie worden vaak bestudeerd in LPS-inflammatiemodellen. Deze inflammatiemodellen kunnen vervolgens toegepast worden in farmacodynamiekstudies om het klinisch effect van anti-inflammatoire geneesmiddelen, zoals niet-steroïdale ontstekingsremmers (NSAIDs) te beoordelen. In dit artikel wordt een overzicht gegeven van de LPS-geïnduceerde inflammatoire respons bij vogels.

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Modulation by gamithromycin and ketoprofen of in vitro and in vivo porcine lipopolysaccharide-induced inflammation

Cited by 24 publications

References 69 publications

Potential of plant polyphenols to combat oxidative stress and inflammatory processes in farm animals

Potential of plant polyphenols to combat oxidative stress and inflammatory processes in farm animals

In vivo porcine lipopolysaccharide inflammation models to study immunomodulation of drugs

Pathofysiologie van lipopolysaccharide geïnduceerde inflammatoire respons bij vogels

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