Modulating stability and mechanical properties of silica–gelatin hybrid by incorporating epoxy‐terminated polydimethylsiloxane oligomer

Abstract

ABSTRACT:Silica-gelatin hybrids, particularly GT-G hybrids prepared by crosslinking gelatin (G) with cglycidoxypropyltrimethoxysilane (GT), have attracted much attention in tissue engineering for diverse applications in hard or soft tissue regeneration; however, scaffolds with tunable properties are needed to meet specific requirements. In this work, a silica-gelatin hybrid (ES/GT-G) was synthesized by incorporating epoxy-terminated polydimethylsiloxane oligomer (ES) to modulate the properties of GT-G hybrid. The ES/GT-G hybrid sponge presented a 3D network structure with porosity 86.4% 6 0.9%, determined by the liquid displacement method, and average pore size 340 6 36 lm, determined by SEM observation. Compared with GT-G hybrid material, the prepared ES/GT-G hybrid wet film showed a decrease of tensile strength from 2.79 6 0.04 MPa to 1.87 6 0.12 MPa, with an increase of elongation at break from 19.96 6 0.66% to 29.86 6 0.87%, and the ES/GT-G hybrid sponge exhibited a decline of compressive yield strength from 1.21 6 0.04 MPa to 0.72 6 0.06 MPa, based on the tensile and compression tests respectively. The introduction of ES enhanced the thermal denaturing temperature of GT-G by 58C as determined by a DSC study, and increased in vitro biodegradation slightly, without significantly changing surface wettability and swelling behavior. These findings suggest that silicagelatin hybrids with tunable properties are promising for applications from hard to soft tissue regeneration. V C 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016, 133, 43059.

Action of silicic acid derived from sodium silicate precursor toward improving performances of porous gelatin membrane

“…Total porosity of the sample was determined according to the liquid displacement method . And the detailed determination was shown in Supporting Material S4.…”

“…On the other hand, gelatin (GE), a biodegradable polymer derived from collagen, has been widely used in many fields including tissue regeneration, food industry, cosmetic, and targeted drug delivery, due to its excellent solubility, low toxicity, good bioresorbability, favorable degradability, easy to be modified, and so on . With respect to silica‐GE hybrid materials, our group found incorporation of epoxy‐terminated polydimethylsiloxane oligomer could enhance its thermal stability, flexibility, and biodegradability, and revealed that the in vitro degradation behavior could be modulated by controlling the dosage of silica‐containing component .…”

Nano-Sio2 Application in the Manufacturing Technology of Elastic Skins

“…Аналіз літературних джерел інформації свідчить про можливість використання сполук кремнію в процесі дублення шкіряного напівфабрикату. Так, у [3], в результаті дослідження впливу гліцидоксипропілтриметокси-сілану та сумісно з епоксиполідіметилсілоксановим олігомерам і 1,5% сполуками хрому основністю 33% на структурні властивості козлини встановлено, що зі збільшенням витрат сполук органосілікону підвищується пористість шкіряного напівфабрикату та його гідротермічна стійкість. Додаткове застосування сполук хрому з органосіліконом сприяє підвищенню цих показників.…”

Influence of the weight ratio of polydimethylsiloxane modified gelatin to silicone rubber on the potential performance of asymmetric bilayer membranes as wound dressings

“…However, poor mechanical strength, high hydrophilicity and rapid degradability greatly limit its effective and wide application . Our previous studies demonstrated that the incorporation of polydimethylsiloxane (PDMS) chains in GE molecules could improve the mechanical flexibility, porous structure and degradation resistance, but the proposed GE‐based materials are simply designed as a single‐layer film . In contrast, silicone rubber (SR), a typical synthetic material, has inherent hydrophobicity, high flexibility and good biocompatibility but poor biodegradability .…”

“…15,16 Our previous studies demonstrated that the incorporation of polydimethylsiloxane (PDMS) chains in GE molecules could improve the mechanical flexibility, porous structure and degradation resistance, but the proposed GE-based materials are simply designed as a single-layer www.soci.org W Du, Z Zhang, Z Li film. [17][18][19] In contrast, silicone rubber (SR), a typical synthetic material, has inherent hydrophobicity, high flexibility and good biocompatibility but poor biodegradability. 20,21 As known from the self-stratification strategy, the combination of GE or modified GE and SR is a feasible approach to fabricate a porous bilayer membrane, thus expressing their respective advantages.…”