Modulating pH-independent release from coated pellets: Effect of coating composition on solubilization processes and drug release

Safety and Robustness of Coated Pellets: Self-Healing Film Properties and Storage Stability

“…The release from both samples (sample III and IV) was not affected by the media change after 2 h from pH 1.2 to 6.8 (Fig. 4a, b), which underlined the pH independent drug release from PVAc/ PVA-PEG coated CPM pellets, reported in various previous publications (19,20).…”

“…The CPM pellets were coated in the same fluid bed coater to different film coat thickness, using three coating dispersions with different PVAc/PVA-PEG ratios (Table I, samples I-IV). The process parameters from pellet layering and coating as well as the preparation of the coating dispersion were published in a previous article (20).…”

“…PVAc), can be adjusted via the film coat thickness, the type and concentration of plasticizer (14) as well as by addition of a soluble pore former to the film coat composition (16). The successful use of poly(vinyl alcohol)-poly(ethylene glycol) graft copolymer (PVA-PEG) as pore forming polymer, in blends with PVAc, has been reported for modified release tablets (17,18) as well for modified release pellets (19,20). Event though, the compressibility and storage stability of PVAc coated dosage forms was already investigated (6,14), the influence of the addition of PVA-PEG on storage stability and compressibility is still unexplored.…”

Tanshinone IIA – loaded pellets developed for angina chronotherapy: Deconvolution-based formulation design and optimization, pharmacokinetic and pharmacodynamic evaluation

“…The variation of the blend ratio of coating components is an efficient way to modify drug release patterns for the formulation (Ensslin et al, 2009). In vitro release behaviors of TA-SRPs coated with different ratios (90:10, 85:15, 70:30 w/w) of PVAc/PVA-PEG at the same coating weight of 5% (w/w) were evaluated and compared with the desired drug release profile by f 2 analysis.…”

“…In addition to the blend ratio variation of PVAc/PVA-PEG, the coating film thickness also plays a vital role in drug release (Ensslin et al, 2009). In vitro release behaviors of TA-SRPs coated with 70:30 (w/w) ratio of PVAc/PVA-PEG were investigated at different coating weights (3%, 5%, 10% w/w) and compared with the desired drug release profile by f 2 analysis (Fig.…”