Release Behavior of Tanshinone IIA Sustained-Release Pellets Based on Crack Formation Theory

Liu, Pan; Li, Jin; Liu, Jianping; Yang, Jikun; Fan, Yilin

doi:10.1002/jps.23199

Cited by 7 publications

(2 citation statements)

References 33 publications

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“…By 48 h, nearly full gathering is achieved, resulting in 94.99% light transmittance in the side of the Petri dish, and the nanocomposite also showed a sustained release profile with 20 h time for blood clot dissolution compared to free nattokinase, and the nanocomposite formed on the study also showed good storage ability. 171 To explore more iron oxide nanoparticle benefits on thrombolysis treatment, Cabrera et al used superparamagnetic heating of iron oxide nanoparticles to aid the blood clot dissolution while also using tPA as the primary clot dissolution agent; in this test, whole human blood was stimulated to clot by the addition of adenosine diphosphate (ADP) used as the test bed, in a blood clot that is treated using MHT combined with tPA visibly seen to be more disrupted with more red blood cell (RBC) sediment compared to the blood clot that is treated with tPA alone. This also was validated with the blood clot mass that is reduced to 75.6% with MHT combined tPA compared to 81.3% with tPA only.…”

Section: Iron Oxides Nanorobot For Disease Healing and Treatmentmentioning

confidence: 99%

Crafting Iron Oxides for Next-Generation Biomedical Applications

Amrillah,

Notodidjojo,

Kalimanjaro

et al. 2024

Crystal Growth & Design

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Iron oxides are multifunctional materials that have been extensively explored for many applications, including in novel biomedical applications. However, boosting their ability for biomedical purposes remains a significant challenge. Many strategies have been proposed to increase the feasibility of iron oxides for biomedical applications, such as doping and defect engineering, compositing and decorating, surface and interface engineering, and structure and morphology development. This review focuses on the essential advancements of iron oxides for their implementation in biomedical applications. The discussion starts with the design of iron oxides in biomedical applications, such as drug delivery, heat delivery, contrast agents, biomedical nanorobots, and disease-sensing systems. We also discuss the obstacle of iron oxides in biomedical applications and continue by proposing a plausible strategy to enhance the feasibility of iron oxides in biomedical applications. The provided discussion and perspectives can enrich the information and pave the way to finding strategies to enhance the feasibility of iron oxides in biomedicalrelated applications. We believe that our review also could shed light on how to bring iron oxides close to real implementation for biomedical purposes.

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Section: Iron Oxides Nanorobot For Disease Healing and Treatmentmentioning

confidence: 99%

Crafting Iron Oxides for Next-Generation Biomedical Applications

Amrillah,

Notodidjojo,

Kalimanjaro

et al. 2024

Crystal Growth & Design

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“…Several materials were applied to the TNIIA pellets with sustained release, including hydroxypropyl methylcellulose (HPMC) and surelease, 113 PVP and F68, 115 polyvinyl acetate (PVAc), and poly(vinyl alcohol)poly(ethylene glycol) (PVA-PEG) graft copolymer. 116 In addition, d-alpha-tocopheryl polyethylene glycol succinategraft-PLGA (TPGS-g-PLGA) copolymer and F68 were used to form mixed micelles with improved bioavailability and prolonged circulation times against hepatocellular carcinoma. 114 However, neither of these formulations had a targeted delivery system for the improved cellular uptake of TNIIA.…”

Section: Othersmentioning

confidence: 99%

Recent insights into the biological activities and drug delivery systems of tanshinones

Cai¹,

Zhang²,

Chen³

et al. 2016

IJN

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Tanshinones, the major lipid-soluble pharmacological constituents of the Chinese medicinal herb Tanshen ( Salvia miltiorrhiza ), have attracted growing scientific attention because of the prospective biomedical applications of these compounds. Numerous pharmacological activities, including anti-inflammatory, anticancer, and cardio-cerebrovascular protection activities, are exhibited by the three primary bioactive constituents among the tanshinones, ie, tanshinone I (TNI), tanshinone IIA (TNIIA), and cryptotanshinone (CPT). However, due to their poor solubility and low dissolution rate, the clinical applications of TNI, TNIIA, and CPT are limited. To solve these problems, many studies have focused on loading tanshinones into liposomes, nanoparticles, microemulsions, cyclodextrin inclusions, solid dispersions, and so on. In this review, we aim to offer an updated summary of the biological activities and drug delivery systems of tanshinones to provide a reference for these constituents in clinical applications.

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Tanshinone IIA – loaded pellets developed for angina chronotherapy: Deconvolution-based formulation design and optimization, pharmacokinetic and pharmacodynamic evaluation

Release Behavior of Tanshinone IIA Sustained-Release Pellets Based on Crack Formation Theory

Cited by 7 publications

References 33 publications

Crafting Iron Oxides for Next-Generation Biomedical Applications

Crafting Iron Oxides for Next-Generation Biomedical Applications

Recent insights into the biological activities and drug delivery systems of tanshinones

Tanshinone IIA – loaded pellets developed for angina chronotherapy: Deconvolution-based formulation design and optimization, pharmacokinetic and pharmacodynamic evaluation

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Release Behavior of Tanshinone IIA Sustained-Release Pellets Based on Crack Formation Theory

Cited by 7 publications

References 33 publications

Crafting Iron Oxides for Next-Generation Biomedical Applications

Crafting Iron Oxides for Next-Generation Biomedical Applications

Recent insights into the biological activities and&nbsp;drug delivery systems of tanshinones

Tanshinone IIA – loaded pellets developed for angina chronotherapy: Deconvolution-based formulation design and optimization, pharmacokinetic and pharmacodynamic evaluation

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Product

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Recent insights into the biological activities and drug delivery systems of tanshinones