Modulating leukocyte recruitment in inflammation

Specific Immunotherapy and Central Immune System

“…Therefore, the local administration of therapeutical allergens limits the local response that rapidly seems to have local-regional and systemic consequences. Probably, not only the biologic mediator produced in situ, as well as the following cell migration, presumably DCs, and the cellular limitations in venular structures in the proximity of the allergenic, allow the amplification of the systemic effect by mechanisms, possibly similar to the ones verified in the allergic reaction (Togias, 2004;Kelly, 2007). The qualitative analysis of our SCIT patients corroborates, although indirectly, the complexity of the tolerance mechanisms, well described in the literature.…”

“…Although the main immunomodulator mechanism is already well established in SIT, it can dictate, in a limited and controlled approach, the effective inflammatory allergic reaction at the administration site. Therefore, we can admit that the autologous reinjection of leucocytes will have a migration dependent of the mast cell activation mediated by IgE (Togias, 2004;Kelly, 2007). This local inflammatory allergic reaction is, presumably, responsible for the dynamics of a response similar to allergy.…”

Lectin from Crataeva tapia bark exerts antitumor, anti-inflammtory and analgesic activities

“…It acts as an anti-inflammatory and immunosuppressant. It is possible that CrataBL antiinflammatory activity may be due to interference with the release of a cascade of inflammatory mediators since inhibition of leukocyte recruitment might prevent inappropriate inflammation 19 .…”

SASH1 Is a Scaffold Molecule in Endothelial TLR4 Signaling

“…The expression of Sash1 in microvascular endothelial cells, as well as the novel scaffolding function described in this study, may provide insight into the cell typespecific responses to LPS and the molecular events that lead to endothelial dysfunction and vascular collapse in sepsis. Endothelial cells, through the upregulation of surface adhesion molecules, such as E-selectin and VCAM-1, serve as important mediators of leukocyte recruitment following LPS challenge (46). However, it remains unclear whether the endothelial events initiated during inflammation are an indirect result of LPS activation of immune cells or a direct effect on the endothelium.…”