Modulating cellular cytotoxicity and phototoxicity of fluorescent organic salts through counterion pairing

Broadwater, Deanna; Bates, Matthew; Jayaram, Mayank; Young, Margaret; He, Jianzhou; Raithel, Austin L.; Hamann, Thomas W.; Zhang, Wei; Borhan, Babak; Lunt, Richard R.; Lunt, Sophia Y.

doi:10.1038/s41598-019-51593-z

Cited by 31 publications

(36 citation statements)

References 46 publications

(42 reference statements)

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“…Rose Bengal medium is also used [ 37 , 38 ], being both a selective and differential medium in that the Rose Bengal dye is taken up by fungi more than other organisms but has the problem of becoming toxic when exposed to light [ 49 , 50 ].…”

Section: Introductionmentioning

confidence: 99%

A comparison of several media types and basic techniques used to assess outdoor airborne fungi in Melbourne, Australia

Black¹

2020

PLoS ONE

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Despite the recent increase in interest in indoor air quality regarding mould, there is no universally accepted standard media for the detection of airborne fungi, nor verification of many commonly used techniques. Commonly used media including malt-extract agar (MEA), Sabouraud dextrose agar (Sab), potato dextrose agar (PDA) with and without antibiotics chloramphenicol & gentamycin (CG) were compared for their suitability in detecting a range of airborne fungi by collecting 150 L outdoor air on a number of different days and seasons via an Anderson 400-hole sampler in suburban Melbourne, Australia. There was relatively little variation in mean numbers of colony forming units (CFU) and types of fungi recovered between MEA, PDA, Sab media groups relative to variation within each group. There was a significant difference between Sab, Dichloran-18% glycerol (DG18) and V8® Original juice agar media, however. Antibiotics reliably prevented the growth of bacteria that typically interfered with the growth and appearance of fungal colonies. There was no significant evidence for a growth enhancing factor from potato, mineral supplements or various vegetable juices. Differing glucose concentrations had modest effects, showing a vague ideal at 2%-4% with peptone. Sanitisation of the aluminium Andersen 400-hole sampler top-plate by flame is possible, but not strictly required nor advisable. The use of SabCG as a standard medium was generally supported.

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Section: Introductionmentioning

confidence: 99%

A comparison of several media types and basic techniques used to assess outdoor airborne fungi in Melbourne, Australia

Black¹

2020

PLoS ONE

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“…In the past five years, the ability to modify the counterion of promising theranostic cyanine and rhodamine salts has proved useful in increasing the quantum yield (74-77), forming self-assembling nanoparticles, and modulating the passive cytotoxicity without light irradiation (78,79). Even more compelling, the organic salt formulation has been used to modulate electronic energy levels independent of the bandgap by way of counterion pairing to selectively generate ROS, enabling precise tunability of both cytotoxicity and phototoxicity (80). Several optimized cyanine dyes are currently undergoing preclinical trials to assess therapeutic efficacy capability (30,81); however, there are many analogs undergoing clinical trials for diagnostics and FGS (82,83).…”

Section: Fluorescent Small Moleculesmentioning

confidence: 99%

Current Advances in Photoactive Agents for Cancer Imaging and Therapy

Broadwater

Medeiros

Lunt

et al. 2021

Annu. Rev. Biomed. Eng.

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Photoactive agents are promising complements for both early diagnosis and targeted treatment of cancer. The dual combination of diagnostics and therapeutics is known as theranostics. Photoactive theranostic agents are activated by a specific wavelength of light and emit another wavelength, which can be detected for imaging tumors, used to generate reactive oxygen species for ablating tumors, or both. Photodynamic therapy (PDT) combines photosensitizer (PS) accumulation and site-directed light irradiation for simultaneous imaging diagnostics and spatially targeted therapy. Although utilized since the early 1900s, advances in the fields of cancer biology, materials science, and nanomedicine have expanded photoactive agents to modern medical treatments. In this review we summarize the origins of PDT and the subsequent generations of PSs and analyze seminal research contributions that have provided insight into rational PS design, such as photophysics, modes of cell death, tumor-targeting mechanisms, and light dosing regimens. We highlight optimizable parameters that, with further exploration, can expand clinical applications of photoactive agents to revolutionize cancer diagnostics and treatment.

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“…In [132]. Redox values, zeta potentials, HOMO energy level, as well as optical properties of all [Cy]-based organic salts were determined in that study.…”

Section: Gumbos and Nanogumbos As Chemotherapeutic Agentsmentioning

confidence: 99%

Group of Uniform Materials Based on Organic Salts (GUMBOS): A Review of Their Solid State Properties and Applications

Pérez¹,

Ayala²,

Warner³

2021

Ionic Liquids - Thermophysical Properties and Applications

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Ionic liquids (ILs) are defined as organic salts with melting points below 100 °C. Such ionic compounds are typically formed using bulky cations and/or bulky anions in order to produce liquids or lower melting solids. ILs have been widely explored in several research areas including catalysis, remediation, solvents, separations, and many others. The utility of such compounds has also been recently broadened to include solid phase ionic materials. Thus, researchers have pushed the boundaries of ILs chemistry toward the solid state and have hypothesized that valuable properties of ILs can be preserved and fine-tuned to achieve comparable properties in the solid state. In addition, as with ILs, tunability of these solid-phase materials can be achieved through simple counterion metathesis reactions. These solid-state forms of ILs have been designated as a group of uniform materials based on organic salts (GUMBOS). In contrast to ILs, these materials have an expanded melting point range of 25 to 250 °C. In this chapter, we focus on recent developments and studies from the literature that provide for fine tuning and enhancing properties through transformation and recycling of diverse ionic compounds such as dyes, antibiotics, and others into solid state ionic materials of greater utility.

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Modulating cellular cytotoxicity and phototoxicity of fluorescent organic salts through counterion pairing

Cited by 31 publications

References 46 publications

A comparison of several media types and basic techniques used to assess outdoor airborne fungi in Melbourne, Australia

A comparison of several media types and basic techniques used to assess outdoor airborne fungi in Melbourne, Australia

Current Advances in Photoactive Agents for Cancer Imaging and Therapy

Group of Uniform Materials Based on Organic Salts (GUMBOS): A Review of Their Solid State Properties and Applications

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