Modulating behavioral inhibition by tDCS combined with cognitive training

Ditye, Thomas; Jacobson, Liron; Walsh, Vincent; Lavidor, Michal

doi:10.1007/s00221-012-3098-4

Cited by 206 publications

(148 citation statements)

References 35 publications

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“…This finding is consistent with recent data in the cognitive domain; for instance, a-tDCS applied before task execution enhanced performance of a behavioural inhibition task (Ditye, Jacobson, Walsh, & Lavidor, 2012), and orientation discrimination task (Pirulli et al, 2013). Particularly relevant to our results, Pirulli et al (2013) showed that, when compared to the sham condition, offline a-tDCS over V1 has a bigger behavioural effect on an orientation discrimination task compared to online a-tDCS.…”

Section: The Relevance Of Timing In Visual Cognitionsupporting

confidence: 93%

Anodal-tDCS over the human right occipital cortex enhances the perception and memory of both faces and objects

et al. 2016

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Accurate face processing skills are pivotal for typical social cognition, and impairments in this ability characterise various clinical conditions (e.g., prosopagnosia). No study to date has investigated whether transcranial direct current stimulation (tDCS) can causally enhance face processing. In addition, the category-and the process-specificity of tDCS effects, as well as the role of the timing of neuromodulation with respect to the execution of cognitive tasks are still unknown. In this single-blind, sham-controlled study, we examined whether the administration of anodal-tDCS (a-tDCS) over the right occipital cortex of healthy volunteers (N = 64) enhances performance on perceptual and memory tasks involving both face and object stimuli. Neuromodulation was delivered in two conditions: online (a-tDCS during task execution) and offline (a-tDCS before task execution). The results demonstrate that offline atDCS enhances the perception and memory performance of both faces and objects. There was no effect of online a-tDCS on behaviour. Furthermore, the offline effect was site-specific since a-tDCS over the sensory-motor cortex did not lead to behavioural changes. Our results add relevant information about the breadth of cognitive processes and visual stimuli that can be modulated by tDCS, and about the design of effective neuromodulation protocols, which have implications for advancing theories in cognitive neuroscience and clinical applications.

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Section: The Relevance Of Timing In Visual Cognitionsupporting

confidence: 93%

Anodal-tDCS over the human right occipital cortex enhances the perception and memory of both faces and objects

et al. 2016

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“…For example, training IC with stop-signal tasks (SST) or Go/ NoGo tasks has been found to decrease stop-signal reaction times (SSRT; Guerrieri et al 2012;Manuel et al 2013), or to decrease false alarm rate and/or response time in the trained task, respectively (Schapkin et al 2007;Manuel et al 2010;Johnstone et al 2012;Benikos et al 2013). A few studies, however, did not find such a decrease (e.g., Cohen and Poldrack, 2008), or only in some conditions (Ditye et al 2012). These patterns of behavioral improvements have been hypothesized to follow from improvements in the speed of inhibition processes (White et al 2014;Chavan et al 2015).…”

Section: Introductionmentioning

confidence: 99%

Enhancing frontal top-down inhibitory control with Go/NoGo training

2015

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Whether and how the capacity to inhibit cognitive and motor processes can be trained and the underlying neuroplastic mechanisms remain unclear. Using electrical neuroimaging methods, we investigated how inhibitory control training regimens can be designed to enhance frontal top-down inhibition processes. We trained participants with a Go/NoGo task in which the stimulusresponse mapping rules were systematically varied. This task parameter has indeed be hypothesized to determine the extent to which top-down frontal inhibition processes are involved and thus ultimately reinforced during the training. The effects of training on inhibitory control were assessed by analyzing the event-related potentials (ERPs) measured during the Go/NoGo task with a data-driven time-and electrode-wise 2 9 2 ANOVA with factors Session (beginning; end of the training) and Stimuli (Go; NoGo). To localize the sources of the ERP effects in the brain, the same statistical design was applied to distributed electrical source estimations averaged over the periods of ERP modulations. The training improved inhibitory control performance. Electrophysiologically, we found a significant Session 9 Stimulus interaction at 300-400 ms poststimulus onset over centro-occipital electrodes. Statistical parametric mapping on the brain source estimations revealed an interaction within right inferior frontal cortices driven by a decrease in response strength to NoGo but not to Go trials in this region. Our collective results demonstrate that frontal top-down inhibition processes can be enhanced with specifically designed inhibitory control training regimens.

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“…Current studies include combining transcranial direct current stimulation with CRT. 100 Other approaches, such as paired associative stimulation and theta-burst stimulation, are in their incipient stages in the study and treatment of schizophrenia, with promising early results. There is some suggestion that repetitive transcranial magnetic stimulation might reduce cravings for tobacco, and this may be promising for the many people with schizophrenia who smoke.…”

Section: Neurostimulationmentioning

confidence: 99%

Role of cognitive enhancement in schizophrenia

Galletly¹

2014

NAN

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Schizophrenia is a severe and usually chronic psychiatric disorder characterized by dysfunction in many domains. Hallucinations, delusions, and behavioral disturbances are prominent symptoms of the illness, and are appropriately a focus for treatment, but less attention is given to the cognitive deficits that are also typically found in schizophrenia. Whilst impairments in learning, memory, and executive function have been recognized for many decades, deficits in more subtle aspects of cognition have been recognized more recently. These include biases in the evaluation of information and difficulties with emotional and social cognition. Cognitive deficits make a substantial contribution to real-world function, and improving cognition has the potential to improve social and vocational outcomes. This review provides an overview of potential treatments for cognitive deficits in schizophrenia, including medications, psychological therapies, and neurostimulation. Despite optimal medication and case management, many people with schizophrenia do not achieve full remission. There is sufficient evidence to encourage widespread adoption of at least some of the current cognitive enhancement strategies. However, individual patients differ in terms of their symptoms, patterns of cognitive dysfunction, medication response, and social and occupational situations. Considerable work is therefore needed to personalize cognitive remediation to maximize the benefits. However, at present, these methods are underutilized, even when applied in a universal manner where all subjects receive the same treatment. The barriers to wider availability of these treatments are discussed.

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Modulating behavioral inhibition by tDCS combined with cognitive training

Cited by 206 publications

References 35 publications

Anodal-tDCS over the human right occipital cortex enhances the perception and memory of both faces and objects

Anodal-tDCS over the human right occipital cortex enhances the perception and memory of both faces and objects

Enhancing frontal top-down inhibitory control with Go/NoGo training

Role of cognitive enhancement in schizophrenia

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